Results 121 to 130 of about 46,527 (261)
Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases
Journal of Periodontal Research, EarlyView.This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi +10 more
wiley +1 more source
reservedIl Toll-like Receptor 9 (TLR9) è un recettore transmembrana appartenente alla classe dei Pathogen Recognition Receptors (PRR), in grado di riconoscere il DNA esogeno di origine batterica ricco in sequenze CpG non metilate in modo tale da ...
MORDENTI, SARAH
core
Blocking TIR Domain Interactions in TLR9 Signaling
, 2018 Interaction of TLR9 with ligands activates NF-κB, leading to proinflammatory cytokine production. Excessive TLR activation is a pathogenic factor for inflammatory diseases.
Artur Javmen +3 more
core +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction
Mediators of Inflammation, 2013 The involvement of toll-like receptor 9 (TLR9), a receptor for bacterial DNA, in septic cardiac depression has not been clarified in vivo. Thus, the aim of the study was to test possible TLR9 inhibitors (H154-thioate, IRS954-thioate, and chloroquine) for
O. Boehm +9 more
doaj +1 more source
Critical role of TLR9 in acute graft-versus-host disease
, 2008 Graft-vs-host disease (GVHD) is a major complication after allogeneic bone marrow transplantation. Different studies have demonstrated that intestinal bacterial breakdown products and loss of gastrointestinal tract integrity, both induced by conditioning
C. Calcaterra* +6 more
core +1 more source
Periodontology 2000, EarlyView.Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng +4 more
wiley +1 more source
Study of TLR9 at the B cell plasmic membrane : commercial anti-TLR9 antibodies characterization
, 2018 Des lymphocytes B (LB) appelés LB régulateurs (LBreg) jouent un rôle primordial dans le contrôle de la réponse immunologique.Ces LBreg peuvent être induits suite à une stimulation.
Cumin, Marie
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Histiocytes: Multifaceted Regulators of Health and Disease
Veterinary Clinical Pathology, EarlyView.ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
Function and regulation of TLR9
, 2008 Macrophages, dendritic cells and B cells detect bacterial DNA containing unmethylated CpG motifs via Toll-like receptor 9 (TLR9) and respond by producing proinflammatory mediators such as IL-6, IL-12 and TNF, and upregulating cell surface expression of ...
Angela Trieu
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