Results 121 to 130 of about 38,400 (238)
MedComm, Volume 7, Issue 8, August 2026.Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong +8 more
wiley +1 more source
The Pharmacology of the SLC15A4‐TASL Complex, an Emerging Target for the Treatment of Lupus
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT SLC15A4 is a member of the solute carrier superfamily that has been strongly linked to the pathogenesis of the auto‐immune disease SLE. The endo‐lysosomally localized SLC15A4 has traditionally been considered a proton‐dependent histidine and peptide transporter, but has also been shown to facilitate TLR7, 8, and 9 induced IFN‐alpha signaling ...
Alex L. Wilkinson +5 more
wiley +1 more source
Engineered Bacterial Membranes as Next‐Generation Platforms for Cancer Immunotherapy
Small Science, Volume 6, Issue 8, August 2026.Engineered bacterial membrane platforms, including outer membrane vesicles, bacterial ghosts, genetically engineered membranes, and hybrid bacterial–tumor membranes, integrate tumor antigen presentation with intrinsic immune stimulation. These platforms promote dendritic‐cell activation, T‐cell priming, pyroptosis, and synergistic responses with ...
Hafiza Aasia Malik +4 more
wiley +1 more source
Liver International, Volume 46, Issue 8, August 2026.ABSTRACT Hepatotoxicity is a common and significant adverse effect associated with adeno‐associated virus (AAV) gene therapy; however, the underlying mechanisms remain unknown. In this study, we demonstrated innate immune activation in two patients with spinal muscular atrophy shortly after receiving AAV9 gene therapy with onasemnogene abeparvovec ...
Aiko Sakai +7 more
wiley +1 more source
Experimental Models of Autoimmune Hepatitis: Disease Fidelity and Translational Relevance
Liver International, Volume 46, Issue 8, August 2026.ABSTRACT Autoimmune hepatitis (AIH) remains difficult to study mechanistically in patients because disease initiation is rarely observed directly, the relevant autoantigens differ across subsets, and clinically meaningful outcomes such as chronic inflammation, fibrosis, relapse, and treatment response evolve over time.
Laura Elisa Buitrago‐Molina +1 more
wiley +1 more source
Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases
Obesity Reviews, Volume 27, Issue 8, August 2026.ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar +4 more
wiley +1 more source
TLR9 Trafficking and Signaling
, 2019 Toll-like Receptor 9 (TLR9) is an endosomal receptor found highly expressed in B cells and plasmacytoid dendritic cells (pDCs). It is activated by unmethylated CpG DNA and synthetic CpG oligodeoxyribonucleotides (ODNs) to produce pro-inflammatory cytokines (TNFα, IL-12) and type I interferons (IFNs).
openaire +1 more source
Molecular Oral Microbiology, Volume 41, Issue 4, Page 227-238, August 2026.Pg releases OMVs which contain Pg genomic DNA. The Pg OMVs‐associated DNA is incorporated into astrocytes via endocytosis and increases IL‐6 mRNA expression via TLR9. These effects of Pg OMVs may induce neuroinflammation, which could contribute to the onset and progression of AD in periodontal disease.
Ayu Takai +7 more
wiley +1 more source
Natural Biomaterials for Osteochondral Repair: From Source to Strategy
Advanced Healthcare Materials, Volume 15, Issue 27, 17 July 2026.Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu +5 more
wiley +1 more source