Results 131 to 140 of about 46,527 (261)
Schematic of Hb-mediated TLR9 pathway.
, 2017 Hb redox reactions cause lipid peroxidation that leads to release of uncontained nucleic acids from either necrotic cell death or excision of damaged mitochondrial (mt) DNA.
Katherine Redinius (3713365) +11 more
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The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
Gq Signaling in Microglia Triggers Interferon Responses and Improves Outcome After Ischemic Stroke
Glia, Volume 74, Issue 10, October 2026.Chemogenetic activation of Gq signaling in microglia ahead of ischemic stroke reduces infarct size in mice. Seven days after stroke, Gq‐primed microglia in the penumbra show enhanced interferon responses, altered branching patterns, and reduced phagocytosis.
Lynn Bitar +8 more
wiley +1 more source
TLR9 expression is HO-1 dependent.
, 2017 Panel A: Wild type PMCs were pre-treated with CoPP (HO-1 inducer) or ZnPP-IX (HO-1 inhibitor) for 1 h followed by MRSA infection for 3 and 6h. Data presented is ±SD of three experiments. Statistical significance *p-/- PMCs were pretreated with CORM-2 (CO
Najmunnisa Nasreen (3615656) +4 more
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Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease
MedComm, Volume 7, Issue 10, October 2026.NETs as integrated effectors in the atherosclerotic cardiovascular disease continuum. Activated neutrophils release NETs that promote endothelial injury, thrombo‐inflammation, and plaque destabilization throughout atherosclerotic disease progression. Created with BioRender.com.
Ji Zhang +9 more
wiley +1 more source
TLR9 expression was detected in non-B cancer cell lines.
, 2012 A, TLR9 mRNA was detected in several cancer cell lines, HeLa MR, HeLa, HT-29, SW480, U-2 OS, 293 and 293T, by RT-PCR. Raji, as positive control; GAPDH, internal control. B, TLR9 expression was detected in HeLa MR cells by flow cytometry.
Ling Zhao (111365) +10 more
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Mucosal‐Associated Invariant T Cells in Health and Disease
MedComm, Volume 7, Issue 10, October 2026.The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao +5 more
wiley +1 more source
TLR9 is upregulated in non-infected BMDMs.
, 2019 (A) BMDMs were infected with MOI:0.01 H1N1 and cells were stained for expression of F480, TLR9 and NP by flow cytometry after 24 or 48 h. Flow plots are representative of n = 4–5 samples with similar results in 2 experiments.
Stephen J. Gurczynski (5673044) +8 more
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Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Fanny Duhalde +2 more
wiley +1 more source
Supplemental Figure S1. Relationship between the histological score (Hscore) for TLR9 immunolabeling and the amount of acid-fast bacilli (AFB category) in tissue sections. Supplemental Figure S2. Western blot analysis of (A) TLR1, (B) TLR2, (C) TLR4,
Benavides, Julio +8 more
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