Results 141 to 150 of about 74,934 (299)

Triad3A-Mediated K48-Linked ubiquitination and degradation of TLR9 impairs mitochondrial bioenergetics and exacerbates diabetic cardiomyopathy

Journal of Advanced Research
Introduction: Targeted protein degradation represents a promising therapeutic approach, while diabetic cardiomyopathy (DCM) arises as a consequence of aberrant insulin secretion and impaired glucose and lipid metabolism in the heart..
Chunyan Kong, Zhen Guo, Fangyuan Liu, Nan Tang, Mingyu Wang, Dan Yang, Chenfei Li, Zheng Yang, Yulan Ma, Pan Wang, Qizhu Tang   +10 more
doaj   +1 more source

Ammonia-Induced Brain Edema Requires Macrophage and T Cell Expression of Toll-Like Receptor 9Summary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aim: Ammonia is central in the pathogenesis of brain edema in acute liver failure (ALF) with infection and systemic inflammation expediting development of intracranial hypertension (ICH).
Godhev Kumar Manakkat Vijay, Changyun Hu, Jian Peng, Irma Garcia-Martinez, Rafaz Hoque, Rejina Mariam Verghis, Yun Ma, Wajahat Zafar Mehal, Debbie Lindsay Shawcross, Li Wen   +9 more
doaj   +1 more source

Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility

Scientific Reports, 2019
Single nucleotide polymorphisms (SNPs) in TLR genes may serve as a crucial marker for early susceptibility of various cancers including cervical cancer.
Nilesh Pandey, Alex Chauhan, Nitin S. Raithatha, Purvi K. Patel, Ronak Khandelwal, Ajesh N. Desai, Yesha Choxi, Rutul S. Kapadia, N. Jain   +8 more
semanticscholar   +1 more source

Surmounting Recalcitrant Airway Inflammatory Disorders With a Multi‐Targeting Therapeutic Strategy by Tannic Acid‐Modified CuInP2S6 Nanosheets

Exploration, EarlyView.
Our findings underscore a multi‐targeting strategy for severe airway inflammation that multi‐targeting nanoformulation C‐TA1 markedly attenuated airway inflammation by (1) cfDNA elimination to alleviate neutrophilic/eosinophilic inflammation mediated by the TLR9 pathway, (2) prevention of RONS‐induced tissue injury and inflammatory response, (3 ...
Ming Liu, Changyi Xu, Renqiang Ma, Xinran Xie, Ying Xie, Mengya Du, Zhaofeng Xu, Shuaiyin Zhang, Jian Li, Weiping Wen, Zhaoxu Tu   +10 more
wiley   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Influenza-induced immune suppression to methicillin-resistant Staphylococcus aureus is mediated by TLR9.

PLoS Pathogens, 2019
Bacterial lung infections, particularly with methicillin-resistant Staphylococcus aureus (MRSA), increase mortality following influenza infection, but the mechanisms remain unclear.
Giovanny J Martínez-Colón, Helen Warheit-Niemi, Stephen J Gurczynski, Quincy M Taylor, Carol A Wilke, Amy B Podsiad, Joel Crespo, Urvashi Bhan, Bethany B Moore   +8 more
doaj   +1 more source

Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia

Frontiers in Cardiovascular Medicine, 2018
Background: Peripheral artery disease causes significant functional disability and results in impaired quality of life. Ischemic tissue injury releases various endogenous ligands for Toll-like receptors (TLRs), suggesting the involvement of TLRs in blood
Sachiko Nishimoto, Kunduziayi Aini, Daiju Fukuda, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Michio Shimabukuro, Masataka Sata   +13 more
doaj   +1 more source

Inhibition of Ctsk modulates periodontitis with arthritis via downregulation of TLR9 and autophagy

Cell Proliferation, 2019
The mechanisms underlying the effects of Toll‐like receptor 9 (TLR9) and autophagy on rheumatoid arthritis (RA)‐aggravated periodontitis are unclear.
Wei Wei, Jie Ren, Wuwei Yin, Handong Ding, Qiuyu Lu, Liangyu Tan, Shibing Deng, Jieliu Liu, Qin-Nan Yang, Jiajia Wang, Min Wang, Y. Yue, L. Hao   +12 more
semanticscholar   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Effect of high mobility group box 1 on Toll-like receptor 9 in B cells in myeloperoxidase-ANCA-associated vasculitis

Autoimmunity, 2020
High mobility group box 1 (HMGB1) played pathogenic role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Recent findings demonstrated that Toll-like receptor 9 (TLR9) was involved in B cell tolerance breaking of autoimmune ...
Chen Wang, Hui Deng, Yan Gong, Ran You, Min Chen, Ming-Hui Zhao   +5 more
doaj   +1 more source