Cell Death and Disease, 2023 Endoplasmic reticulum (ER) stress and ER stress-mediated apoptosis play an important role during secondary brain damage after traumatic brain injury (TBI).
Li Mi +12 more
semanticscholar +1 more source
Immunocytochemical characteristic of the endometrial mucosa HIV-infected women [PDF]
Гинекология, 2020 Relevance. Human immunodeficiency virus (HIV) infection is an independent factor in reduced fertility and a risk factor for miscarriage. There are some date an endometrial receptivity of HIV-infected patients has changed that plays an important role in ...
Irina N. Vorobtsova +5 more
doaj +1 more source
B cell–intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice
JCI Insight, 2023 The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is enhanced when the regulatory role of TLR9 is absent. TLR7 signaling in plasmacytoid DCs (pDC) is
Haylee A Cosgrove +5 more
semanticscholar +1 more source
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia
Science Translational Medicine, 2021 Description Red blood cells detect and bind cell-free nucleic acids, contributing to anemia and immune cell activation during acute inflammation. DNA sensing by RBCs Red blood cells (RBCs) have historically been considered immunologically inert.
L. M. Lam +16 more
semanticscholar +1 more source
TLR9 regulates NLRP3 inflammasome activation via the NF-kB signaling pathway in diabetic nephropathy
Diabetology & Metabolic Syndrome, 2022 Background Toll-like receptors (TLRs) are critical sensors for the conservation of bacterial molecules and play a key role in host defense against pathogens.
Jinfeng Shen +4 more
semanticscholar +1 more source
Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage
Vascular pharmacology, 2021 Background and purpose Mitochondria play a central role in the host response to viral infection and immunity, being key to antiviral signaling and exacerbating inflammatory processes.
T. J. Costa +26 more
semanticscholar +1 more source
Mechanisms of TLR9 activation [PDF]
Journal of Endotoxin Research, 2004 Non-methylated CpG-motifs in bacterial or viral DNA are recognized by TLR9 as foreign. The activation of TLR9 by microbial DNA or synthetic oligonucleotides based on these motifs leads to the induction of innate immune responses. We have compared the subcellular localization of fluorescent versions of TLR9 and TLR4 and found that TLR9 is expressed in ...
Eicke, Latz +3 more
openaire +2 more sources
HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway [PDF]
, 2020 It is known that herpes simplex virus type 2 (HSV-2) triggers the activation of Toll-like receptor (TLR) 9 signaling pathway and the consequent production of antiviral cytokines in dendritic cells.
Barreto, M +11 more
core +1 more source
TLR9 and COVID-19: A Multidisciplinary Theory of a Multifaceted Therapeutic Target
Frontiers in Pharmacology, 2021 By mapping the clinical pathophysiology of the novel coronavirus disease 2019 (COVID-19) against insights from virology, immunology, genomics, epidemiology and pharmacology, it is here proposed that the pathogen recognition receptor called toll like ...
Gillina F. G. Bezemer, J. Garssen
semanticscholar +1 more source
Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation [PDF]
, 2014 Funding: JW and NARG thank the Wellcome Trust (080088, 086827, 075470), The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) for funding. MGN was supported
Biedermann, Tilo +12 more
core +8 more sources