Results 21 to 30 of about 74,934 (299)
Insights into innate immune activation via PS-ASO–protein–TLR9 interactions
Nucleic Acids Research, 2022 Non-CpG PS-ASOs can activate the innate immune system, leading to undesired outcomes. This response can vary—in part—as a function of 2′modifications and sequence.
Adam J. Pollak +5 more
semanticscholar +1 more source
TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism
Frontiers in Endocrinology, 2021 Toll-Like Receptor 9 (TLR9) is an ancient receptor integral to the primordial functions of inflammation and metabolism. TLR9 functions to regulate homeostasis in a healthy system under acute stress.
C. Shepard
semanticscholar +1 more source
The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis
口腔疾病防治, 2021 Mucositis is a common gastrointestinal complication in cancer patients undergoing chemoradiotherapy, including oral mucositis and gastrointestinal mucositis, with clinical manifestations of oral ulcers, vomiting, diarrhea and pain that seriously reduce ...
JI Ling +3 more
doaj +1 more source
TLR9 Mediates Periodontal Aging by Fostering Senescence and Inflammaging
Journal of dentistry research, 2022 TLR9 is a critical nucleic acid sensing receptor in mediating periodontitis and periodontitis-associated comorbidities. Emerging evidence implicates TLR9 as a key sensor during aging, although its participation in periodontal aging is unexplored.
E. Albuquerque‐Souza +7 more
semanticscholar +1 more source
The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
Current Issues in Pharmacy and Medical Sciences, 2020 The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers.
Dworzanska Anna +1 more
doaj +1 more source
Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice [PDF]
The Journal of Immunology, 2013 Abstract Recognition of nucleic acids by TLR9 requires its trafficking from the endoplasmic reticulum to endolysosomal compartments and its subsequent proteolytic processing. Both processes depend on interactions of TLR9 with the polytopic endoplasmic reticulum–resident protein UNC93B1.
Avalos, Ana M. +8 more
openaire +3 more sources
MAPK signaling regulates the efficacy of chemoimmunotherapy
Molecular & Cellular Oncology, 2022 Resistance to chemoimmunotherapy is a major issue for cancer care. We recently unravelled the role of mitogen-activated protein kinase (MAPK) to limit the antitumor efficacy of such combination.
François Ghiringhelli
doaj +1 more source
Characterization of cooperative PS-oligo activation of human TLR9
Molecular Therapy: Nucleic Acids, 2023 Single-stranded phosphorothioate oligonucleotides (PS-oligos) can activate TLR9, leading to an innate immune response. This can occur with PS-oligos containing unmethylated CpG sites, the canonical motif, or PS-oligos that do not contain those motifs ...
Adam J. Pollak +2 more
doaj +1 more source
, 2005 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders HJ, H-J Anders, Stacey KJ
core +1 more source
Frontiers in Molecular Neuroscience, 2022 Toll like receptor 9 (TLR9) is a critical sensor for danger-associated molecular patterns (DAMPs) and a crucial marker of non-sterile/sterile inflammation among all TLRs. However, the significance of TLR9 in inflammatory pain remains unclear.
Yu Chen +11 more
doaj +1 more source