Results 41 to 50 of about 74,934 (299)
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. [PDF]
, 2008 Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids; however, these responses come at the cost of potential autoimmunity owing to inappropriate recognition of self nucleic acids.
Barton, Gregory M +6 more
core +2 more sources
Insights on adaptive and innate immunity in canine leishmaniosis [PDF]
, 2016 Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah +19 more
core +4 more sources
Toll-like receptor 9 interaction with CpG ODN – An in silico analysis approach [PDF]
, 2013 BACKGROUND: Toll-like receptor 9 (TLR9) recognises unmethylated CpG DNA and activates a signalling cascade, leading to the production of inflammatory cytokines such as TNF-α, IL-1, IL-6 and IL-12 via the adaptor protein MyD88.
Beiping Li +8 more
core +1 more source
New vistas on TLR9 activation [PDF]
European Journal of Immunology, 2011 AbstractTogether with other reports, evidence published in this issue of the European Journal of Immunology by Avalos and Ploegh (Eur. J. Immunol. 2011. 41: 2820–2827) implies that trafficking of TLR9 from the ER to endolysosomal compartments, which is aided by the transmembrane UNC93B1 ER protein, is followed by proteolytic cleavage of the TLR9 ...
openaire +2 more sources
Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes [PDF]
, 2017 BACKGROUND: Monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; SSc), with increased expression of interferon (IFN)-regulatory genes and inflammatory cytokines, suggesting dysregulation of the ...
Dreyfus, David H. +12 more
core +1 more source
B cell-intrinsic TLR9 expression is protective in murine lupus.
Journal of Clinical Investigation, 2020 Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the opposite effect remains undefined.
Jeremy S. Tilstra +7 more
semanticscholar +1 more source
CHANGES OF INNATE IMMUNITY INDEXES IN SEVERE ASTHMA IN CHILDREN
Медицинская иммунология, 2019 At the present time, the role of innate immunity in pathogenesis of bronchial asthma (BA) is actively studied, in particular, significance of TLRs and cytokines. The study included 42 patients with severe bronchial asthma (from 3 to 12 years old), and 67
L. V. Gankovskaya +9 more
doaj +1 more source
Reversion of anergy signatures in clonal CD21low B cells of mixed cryoglobulinemia after clearance of HCV viremia. [PDF]
, 2017 Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of IgM+CD27+ B cells. These cells display both the features of anergy induced by continual engagement of the B cell receptor (BCR), such as high expression of ...
Casato, Milvia +7 more
core +1 more source
Journal of Immunology, 2020 Key Points A functional cGAS–STING pathway exists in human plasmacytoid dendritic cells. Activation of cGAS–STING in pDCs inhibits TLR9-mediated IFN production. Plasmacytoid dendritic cells (pDCs) are potent producers of type I and type III IFNs and play
P. Deb +4 more
semanticscholar +1 more source
Drug Design, Development and Therapy, 2021 Qingling Guo,1,2 Haili Qu,3 Hong Zhang,4 Xia Zhong4 1Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, People’s Republic of China; 2Department of Endocrinology, Shandong Provincial ...
Guo Q, Qu H, Zhang H, Zhong X
doaj