Results 61 to 70 of about 74,934 (299)
Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells. [PDF]
PLoS ONE, 2011 Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing large amounts of type I interferon (IFN) by sensing the presence of viral infections through the Toll-Like Receptor (TLR) pathway.
Isabelle E Vincent +10 more
doaj +1 more source
Fresh Insights into Disease Etiology and the Role of Microbial Pathogens. [PDF]
, 2016 Pathogens have been implicated in the initiation and/or promotion of systemic sclerosis (scleroderma, SSc); however, no evidence was found to substantiate the direct contribution to this disease in past years.
FARINA, Antonella, Farina, G.a.2.
core +1 more source
Epstein-Barr virus suppresses N6-methyladenosine modification of TLR9 to promote immune evasion
Journal of Biological ChemistryEpstein-Barr virus (EBV) is a human tumor virus associated with a variety of malignancies, including nasopharyngeal carcinoma, gastric cancers, and B-cell lymphomas.
Xiaoyue Zhang +12 more
semanticscholar +1 more source
Nature Communications, 2019 Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis and vasculopathy. CXCL4 represents an early serum biomarker of severe SSc and likely contributes to inflammation via chemokine signaling pathways, but the exact role of ...
R. Lande +20 more
semanticscholar +1 more source
Biology, 2020 Simple Summary We described the existence of an integrated Beclin 1, TLR9, and SIRT3 network involving autophagy, oxidative stress, and mitochondria that is essential for empagliflozin to protect against doxorubicin toxicity in the heart.
Chao-Yung Wang +8 more
semanticscholar +1 more source
Drug Design, Development and Therapy, 2021 Qin Li,1,* Jie Ren,2,* Wei Liu,3 Guoqin Jiang,2 Rongkuan Hu1 1GenePharma Co., Ltd., Suzhou, 215125, Jiangsu, People’s Republic of China; 2Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004,
Li Q, Ren J, Liu W, Jiang G, Hu R
doaj
Toll-like receptor 9 mediated responses in cardiac fibroblasts. [PDF]
PLoS ONE, 2014 Altered cardiac Toll-like receptor 9 (TLR9) signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole.
Ingrid Kristine Ohm +9 more
doaj +1 more source
Negative Self-Regulation of TLR9 Signaling by Its N-Terminal Proteolytic Cleavage Product [PDF]
, 2014 TLR signaling is essential to innate immunity against microbial invaders and must be tightly controlled. We have previously shown that TLR9 undergoes proteolytic cleavage processing by lysosomal proteases to generate two distinct fragments.
Kang, Dongju +5 more
core +2 more sources
Kidney International, 2019 Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). However, the pathogenic mechanisms driving Gd-IgA1 production have not been fully elucidated.
Y. Makita +6 more
semanticscholar +1 more source
Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia. [PDF]
PLoS ONE, 2010 Toll like receptors play an important role in lung host defense against bacterial pathogens. In this study, we investigated independent and cooperative functions of TLR4 and TLR9 in microbial clearance and systemic dissemination during Gram-negative ...
Urvashi Bhan +5 more
doaj +1 more source