Results 71 to 80 of about 74,934 (299)

Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7 [PDF]

, 2018
The excessive production of type I IFNs is a hallmark and a main pathogenic mechanism of many autoimmune diseases, including systemic lupus erythematosus (SLE).
Andreoli, Laura, Bergese, Paolo, Bosisio, Daniela, Busatto, Sara, D'Oro, Ugo, Giannello, Veronica, Salvi, Valentina, Sozzani, Silvano, Tincani, Angela, Zingoni, Alessandra   +9 more
core   +1 more source

CD82 controls CpG‐dependent TLR9 signaling

The FASEB Journal, 2019
The tetraspanin CD82 is a potent suppressor of tumor metastasis and regulates several processes including signal transduction, cell adhesion, motility, and aggregation. However, the mechanisms by which CD82 participates in innate immunity are unknown. We report that CD82 is a key regulator of TLR9 trafficking and signaling.
Khan, Nida S, Lukason, Daniel P, Feliu, Marianela, Ward, Rebecca A, Lord, Allison K, Reedy, Jennifer L, Ramirez-Ortiz, Zaida G, Tam, Jenny M, Kasperkovitz, Pia V, Negoro, Paige E, Vyas, Tammy D, Xu, Shuying, Brinkmann, Melanie M, Acharaya, Mridu, Artavanis-Tsakonas, Katerina, Frickel, Eva-Maria, Becker, Christine E, Dagher, Zeina, Kim, You-Me, Latz, Eicke, Ploegh, Hidde L, Mansour, Michael K, Miranti, Cindy K, Levitz, Stuart M, Vyas, Jatin M   +24 more
openaire   +4 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

TLR9 activation dampens the early inflammatory response to Paracoccidioides brasiliensis, impacting host survival. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P.
João Filipe Menino, Margarida Saraiva, Ana G Gomes-Alves, Diogo Lobo-Silva, Mark Sturme, Jéssica Gomes-Rezende, Ana Laura Saraiva, Gustavo H Goldman, Cristina Cunha, Agostinho Carvalho, Luigina Romani, Jorge Pedrosa, António Gil Castro, Fernando Rodrigues   +13 more
doaj   +1 more source

Below the surface: The inner lives of TLR4 and TLR9

Journal of Leukocyte Biology, 2019
TLRs are a class of pattern recognition receptors (PRRs) that detect invading microbes by recognizing pathogen‐associated molecular patterns (PAMPs). Upon PAMP engagement, TLRs activate a signaling cascade that leads to the production of inflammatory ...
L. Marongiu, L. Gornati, I. Artuso, I. Zanoni, F. Granucci   +4 more
semanticscholar   +1 more source

COVID‐19 Vaccination Is Not Associated With the Development of Idiopathic Inflammatory Myositis in US Veterans

Arthritis Care &Research, EarlyView.
Objective Several case reports have proposed a potential association between COVID‐19 vaccination and the subsequent development of idiopathic inflammatory myositis (IIM). This study examined prior COVID‐19 vaccination in US veterans who developed new‐onset IIM compared to those without new‐onset IIM.
Caleb Hernández, Naomi Schlesinger, Jorge Rojas, Jessica A. Walsh, Tawnie J. Braaten, Gary A. Kunkel, Makoto Jones, Brian C Sauer, Julio Facelli, Grant W. Cannon, Dorota Lebiedz‐Odrobina   +10 more
wiley   +1 more source

Polymorphisms and expression of toll-like receptors in autoimmune thyroid diseases

Autoimmunity, 2017
Graves’ disease (GD) and Hashimoto’s disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production
Naoya Inoue, Yuka Katsumata, Mikio Watanabe, Naoko Ishido, Yu Manabe, Ayano Watanabe, Ryota Masutani, Yoh Hidaka, Yoshinori Iwatani   +8 more
doaj   +1 more source

Single molecule in vivo analysis of toll-like receptor 9 and CpG DNA interaction. [PDF]

PLoS ONE, 2011
Toll-like receptor 9 (TLR9) activates the innate immune system in response to oligonucleotides rich in CpG whereas DNA lacking CpG could inhibit its activation.
Jiji Chen, Suman Nag, Pierre-Alexandre Vidi, Joseph Irudayaraj   +3 more
doaj   +1 more source

TLR9 mediates S. aureus killing inside osteoblasts via induction of oxidative stress [PDF]

, 2016
Background: Staphylococcus aureus is the principle causative pathogen of osteomyelitis and implant-associated bone infections. It is able to invade and to proliferate inside osteoblasts thus avoiding antibiotic therapy and the host immune system ...
Alt, Volker, Chakraborty, Trinad, Domann, Eugen, Heiss, Christian, Lips, Katrin S., Mannala, Gopala, Mohamed, Walid, Schnettler, Reinhard   +7 more
core   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source