Results 111 to 120 of about 21,015 (212)

Trimethylamine oxide supplementation differentially regulates fat deposition in liver, longissimus dorsi muscle and adipose tissue of growing-finishing pigs

Animal Nutrition
Trimethylamine oxide (TMAO) is a microbiota-derived metabolite, and numerous studies have shown that it could regulate fat metabolism in humans and mice. However, few studies have focused on the effects of TMAO on fat deposition in growing-finishing pigs.
Andong Zha, Wanquan Li, Jing Wang, Ping Bai, Ming Qi, Peng Liao, Bie Tan, Yulong Yin   +7 more
doaj   +1 more source

Advance Microbiota Transplantation: A Novel Addition–Subtraction Paradigm for Optimising Faecal Microbiota Transplantation

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
This review proposes Advance Microbiota Transplantation (AMT), a pre‐peri‐post transplant ‘addition–subtraction’ framework that integrates donor–recipient optimisation, product engineering, and post‐transplant recipient adjuvant management to enhance conventional FMT efficacy and mitigate its limitations. ABSTRACT Faecal microbiota transplantation (FMT)
Haojia Lin, Zelin Feng, Qiuyue Tu, Huizhen Li, Yanru Zhang, Xinyue Wei, Qinghua Yi, Hetong Zhang, Yu Wang, Xiaoqin Li, Yueting Li, Jun Huang, Zehan Chen, Hongtian Shentu, Anjiang Wang, Ye Chen, Xiaolong He, Xiaocang Cao   +17 more
wiley   +1 more source

The gut microbiota metabolite trimethylamine N-oxide promotes cardiac hypertrophy by activating the autophagic degradation of SERCA2a

Communications Biology
Trimethylamine oxide (TMAO) is a newly found intestinal microbiota metabolite. Here, we aimed to explore the effects of TMAO on calcium homeostasis and its implication in cardiac hypertrophy, especially focusing on the regulatory mechanism of TMAO on the
Dongyu Lei, Yi Liu, Yuan Liu, Yujie Jiang, Yuyan Lei, Feilong Zhao, Wenqun Li, Zhonghua Ouyang, Lulu Chen, Siyuan Tang, Dongsheng Ouyang, Xiaohui Li, Ying Li   +12 more
doaj   +1 more source

Lifelong TMAO exposure exerts hypotensive effects in aged spontaneously hypertensive rats

Frontiers in Cardiovascular Medicine
Trimethylamine N-oxide (TMAO), a bacterial metabolite associated with cardiovascular risk, has a debated role, with evidence suggesting both harmful and protective effects.
Wojciech Kopacz, Kinga Jaworska, Mateusz Koper, Marcin Ufnal   +3 more
doaj   +1 more source

Impacts of Lifestyle and Microbiota‐Targeted Interventions for Overweight and Obesity on the Human Gut Microbiome: A Systematic Review

Obesity Reviews, Volume 27, Issue 3, March 2026.
Dietary interventions showed the strongest evidence for improving microbiome composition. Probiotics and prebiotics consistently increased beneficial bacteria. Exercise and fecal microbiota transplantation had limited evidence but showed potential for microbiome modulation.
Yee Teng Lee, Ayça Akan, Dilara Beyza Önel, Evelyn Medawar, Daria E. A. Jensen, Arno Villringer, A. Veronica Witte   +6 more
wiley   +1 more source

Potential effects of natural dietary compounds on trimethylamine N-oxide (TMAO) formation and TMAO-induced atherosclerosis

Journal of Food Bioactives, 2018
Cardiovascular disease (CVD) is the leading cause of death worldwide. Recently, trimethylamine N-oxide (TMAO) is identified to be highly associated with CVD development and exacerbates atherosclerosis by several mechanisms. TMAO is a gut microbiota-dependent metabolite formed from dietary quaternary amines, mainly choline and carnitine.
Pei-Yu Chen, Chi-Tang Ho, Fereidoon Shahidi, Min-Hsiung Pan   +3 more
openaire   +2 more sources

Structural mass spectrometry techniques for characterisation of plant and algal proteins

The Plant Journal, Volume 125, Issue 6, March 2026.
SUMMARY Structural biology can offer valuable insights into the mechanisms and functions of key proteins within plant molecular and cellular systems. However, plant proteins present several specific challenges for structural analysis, including difficulties in expression and purification, significant intrinsic disorder, and extensive post‐translational
Rhiannon Durant, Dušan Živković, Jani R. Bolla   +2 more
wiley   +1 more source

TMAO Is Both a Biomarker and a Renal Toxin [PDF]

Circulation Research, 2015
In 2011, Hazen and colleagues1 made the seminal discovery that 3 metabolites of dietary phosphatidylcholine (choline, trimethylamine N-oxide [TMAO] and betaine) predicted risk for cardiovascular disease in an independent large clinical cohort. They also demonstrated that supplementing the diet with choline or TMAO promoted atherosclerosis in a mouse ...
openaire   +2 more sources

Trimethylamine N‐oxide is elevated in postmenopausal women relative to age‐matched men and premenopausal women among individuals with obesity

Experimental Physiology, Volume 111, Issue 3, Page 798-808, 1 March 2026.
Abstract Trimethylamine N‐oxide (TMAO) is linked to arterial stiffness and atherosclerosis. Cardiovascular disease (CVD) risk increases following menopause in women. Whether menopause influences plasma TMAO metabolism to mediate CVD risk is unknown.
Daniel J. Battillo, Steven K. Malin
wiley   +1 more source

Mechanism of TMAO-mediated NLRP3 inflammasome in the pathogenesis of large artery atherosclerosis in the head and neck

徐州医科大学学报
Objective To screen for specific metabolites in patients with large artery atherosclerosis (LAA) in the head and neck and to verify whether these metabolic markers can upregulate the NLR family pyrin domain containing protein 3 (NLRP3) inflammasome to ...
CHEN Zhiren, HUANG Zehua, YANG Meifang, ZHOU Zixuan, CHEN Weiwei, WANG Peian   +5 more
doaj   +1 more source