Results 181 to 190 of about 414,010 (359)

Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer

Advanced Science, EarlyView.
T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, Le Yang, Minggao Zhao, Lei Liang, Gaofei Wei   +13 more
wiley   +1 more source

Regulation of the Target Protein (Transgene) Expression in the Adenovirus Vector Using Agonists of Toll-Like Receptors

, 2014
Alexander Bagaev, Pichugin Av, Е.С. Лебедева, А. А. Лысенко, М. М. Шмаров, Denis Y. Logunov, Boris S. Naroditsky, Ravshan Ataullakhanov, Rakhim M. Khaitov, Gintsburg Al   +9 more
openalex   +1 more source

Macrophage migration inhibitory factor enhances lipopolysaccharide-induced fibroblast proliferation by inducing toll-like receptor 4 [PDF]

, 2016
Zheng-de Xi, Changyi Xie, Yebin Xi
openalex   +1 more source

Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Advanced Science, EarlyView.
Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian, Hangping Yao, Xun Zeng, Yida Yang   +12 more
wiley   +1 more source

Toll-like Receptor 7 Deficiency Attenuates Platelet Dysfunction in Sepsis. [PDF]

Biomolecules
Mohamed-Hinds R, Dutta A, Park C, Yang X, Zou L, Chao W, Williams B.   +6 more
europepmc   +1 more source

The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide [PDF]

Bing Li, Prasanna Suresh, Jack Brelstaff, Shekhar Kedia, Clare Bryant, David Klenerman   +5 more
openalex   +1 more source

Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates

Advanced Science, EarlyView.
Upon rice viral infection, the insect vector activates the Toll–MyD88–Dorsal signaling cascade, inducing i‐type lysozyme (Lyz‐I1) expression. Lyz‐I1 functions as an antiviral protease through its conserved catalytic dyad Glu/Asp (E/D), mediating cleavage of viral proteins at specific Lys (K) residues.
Yu Du, Yuqing Xiao, Manman Hu, Jinhua Yang, You Li, Taiyun Wei   +5 more
wiley   +1 more source

Phosphoproteomic profiling of lipopolysaccharide stimulated toll-like receptor pathways in macrophages. [PDF]

Sci Data
Kim D, Yoon SH, Manes NP, Nita-Lazar A.
europepmc   +1 more source

Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways [PDF]

, 2020
Khadijeh Koushki, Sanaz Keshavarz Shahbaz, Kazem Mashayekhi, Mahvash Sadeghi, Zeinab Deris Zayeri, Mahdieh Yousefi Taba, Maciej Banach, Khalid Al‐Rasadi, Thomas P. Johnston, Amirhossein Sahebkar   +9 more
openalex   +1 more source

PBLD Orchestrates the STING‐Mediated Antiviral Immune Response and Autoimmune Diseases

Advanced Science, EarlyView.
During viral infection, PBLD expression is downregulated, thereby subverting host antiviral defenses and promoting viral replication. This study identifies PBLD as a positive regulator of STING‐induced type I interferon activation and delineated the molecular network underlying PBLD‐mediated antiviral immunity and autoimmune pathogenesis, highlighting ...
Peili Hou, Hongchao Zhu, Xiaonan Sun, Ni Zhang, Song Wang, Xuexing Zheng, Xiaoyun Wang, Yueyue Feng, Fuzhen Zhang, Xingyu Li, Rui Li, Xiaomeng Wang, Yuanyuan Han, Jun Wang, Chuanhong Wang, Xiaoyang Yao, Hongmei Wang, Hongbin He   +17 more
wiley   +1 more source