Results 181 to 190 of about 238,767 (310)

Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy

Advanced Science, EarlyView.
An intelligent lactate‐depleting LOCoF2 (CoF2@LOx) nanoreactor system is developed to effectively induce self‐reinforced pyroptosis and activate the cGAS‐STING signaling pathway, thereby inducing a strong immune response and enhancing the therapeutic effectiveness of catalytic immunotherapy.
Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng   +10 more
wiley   +1 more source

Discovery of ETI41 and ETI60: novel selective endosomal Toll-like receptor inhibitors for the treatment of autoimmune diseases. [PDF]

Exp Mol Med
Jeong U, Lee WH, Choi YS, Haseeb M, Baek WY, Han JH, Choi H, Kim MS, Suh CH, Kim W, Choi S.   +10 more
europepmc   +1 more source

Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus [PDF]

, 2001
Lia M. Haynes, Deborah Moore, Evelyn A. Kurt‐Jones, Robert W. Finberg, Larry J. Anderson, Ralph A. Tripp   +5 more
openalex   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Gut microbiota dysbiosis promotes coronary heart disease comorbid with depression through lipopolysaccharides and Toll-like receptor 4. [PDF]

BMC Microbiol
Pan Y, Luo Y, Wu G, Lu Y, Yang P, Kong P, Zheng C, Wang C, Yang L, Li X.   +9 more
europepmc   +1 more source

Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor andBorrelia burgdorferiOuter Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling [PDF]

, 2001
Yonca Bulut, Emmanuelle Faure, Lisa Thomas, Ozlem Equils, Moshe Arditi   +4 more
openalex   +1 more source

Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance

Advanced Science, EarlyView.
This review comprehensively summarizes the role of mechanotransduction in shaping immunity. It details how immune cells respond to biomechanical cues via mechanotransduction cascades and emphasizes the mechanical crosstalks within the immune microenvironment. The emerging significance of mechanoimmunology in both health and diseases is also highlighted.
Ruijiao Yan, Yuyu Li, Shuo Chen, Li Zhu, Chenchen Zhou, Jianwei Chen, Shujuan Zou, Xianglong Han   +7 more
wiley   +1 more source

Expression of Concern: The IkappaB Kinase Family Phosphorylates the Parkinson's Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors

, 2000
Elke Cario, Ian M. Rosenberg, Steven L. Brandwein, Paul L. Beck, Hans-Christian Reinecker, Daniel K. Podolsky   +5 more
openalex   +1 more source

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite [PDF]

, 2001
Marco Antônio Campos, Igor C. Almeida, Osamu Takeuchi, Shizuo Akira, Eneida P. Valente, Daniela O. Procópio, Luiz R. Travassos, Jason A. Smith, Douglas T. Golenbock, Ricardo T. Gazzinelli   +9 more
openalex   +1 more source