Results 181 to 190 of about 233,587 (310)

Different Toll-like receptor agonists induce distinct macrophage responses [PDF]

, 2001
Bryan W. Jones, Terry K. Means, Kurt A. Heldwein, Marc A. Keen, Preston J. Hill, John T. Belisle, Matthew J. Fenton   +6 more
openalex   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

The immunostimulatory activity of <i>Epimedium</i> flavonoids involves toll-like receptor 7/8. [PDF]

Front Pharmacol
Wu J, Ou Y, Yao M, Liu J, Ran H, Wu Z, Wu R, Gan L, Li D, Jin J.   +9 more
europepmc   +1 more source

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

Programmed Death Ligand 1 Modulation by Bacillus Calmette-Guérin and Toll-Like Receptor Agonists in Distinct Breast Cancer Cell Subtypes. [PDF]

Int J Gen Med
Barbosa G, De Godoy MCX, Bighetto CC, Skakum EM, Pascoal LB, Gambero A, Reis LO.   +6 more
europepmc   +1 more source

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source

The Impact of Toll-Like Receptor 5 on Liver Function in Age-Related Metabolic Disorders. [PDF]

Aging Cell
Kim DH, Go HS, Jeon EJ, Nguyen TQT, Kim DY, Park H, Eom HJ, Kim SY, Park SC, Cho KA.   +9 more
europepmc   +1 more source

Toll-like receptor family and signalling pathway [PDF]

, 2001
Marta Muzio, Nadia Polentarutti, Daniela Bosisio, Prakash P. Kumar, Alberto Mantovani   +4 more
openalex   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Toll-like receptor response to Zika virus infection: progress toward infection control. [PDF]

Npj Viruses
Kayesh MEH, Kohara M, Tsukiyama-Kohara K.   +2 more
europepmc   +1 more source