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Toll-like receptors in the skin
Seminars in Immunopathology, 2007Toll-like receptors (TLRs) are important pattern-recognition receptors involved in host defense against a variety of pathogenic microorganisms. Activation of TLRs leads to the production of cytokines, chemokines, antimicrobial peptides, and upregulation costimulatory and adhesion molecules involved in innate and adaptive immune responses.
Lloyd S. Miller, Robert L. Modlin
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Trends in Molecular Medicine, 2002
A mammalian immune response to microbial organisms requires a series of pattern recognition steps, and nonspecific processes often precede elements of the specific immune system in this process. Molecules such as lipopolysaccharide, peptidoglycan and lipoteichoic acids are relatively conserved, and are recognized in this manner by toll-like receptors ...
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A mammalian immune response to microbial organisms requires a series of pattern recognition steps, and nonspecific processes often precede elements of the specific immune system in this process. Molecules such as lipopolysaccharide, peptidoglycan and lipoteichoic acids are relatively conserved, and are recognized in this manner by toll-like receptors ...
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Viruses and Toll-like receptors
Microbes and Infection, 2004Production of inflammatory cytokines and type I interferons by mammalian cells is mediated through virus-specific activation of Toll-like receptors (TLRs). Known roles for different TLRs and speculation as to their roles in viral pathogenesis and immunity are discussed in this review.
Robert W. Finberg, Evelyn A. Kurt-Jones
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2004
Innate immune system is the sentinel of the host defense mechanisms and consists of variety of immune cells such as macrophages and dendritic cells. They sense pathogen-associated molecular patterns (PAMPs) via family of germline-encoded sensor proteins known as pattern recognition receptors.
Himanshu Kumar +2 more
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Innate immune system is the sentinel of the host defense mechanisms and consists of variety of immune cells such as macrophages and dendritic cells. They sense pathogen-associated molecular patterns (PAMPs) via family of germline-encoded sensor proteins known as pattern recognition receptors.
Himanshu Kumar +2 more
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Journal of Allergy and Clinical Immunology, 2005
The Toll-like receptors (TLRs) are a recently discovered family of receptors involved in the innate recognition of pathogens. TLRs have much homology to the IL-1 receptor family and the Drosophila Toll protein, and at least 10 distinct TLRs have now been identified in human subjects (Fig 1).
Pierre Fiset +2 more
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The Toll-like receptors (TLRs) are a recently discovered family of receptors involved in the innate recognition of pathogens. TLRs have much homology to the IL-1 receptor family and the Drosophila Toll protein, and at least 10 distinct TLRs have now been identified in human subjects (Fig 1).
Pierre Fiset +2 more
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2001
Molecular recognition of bacterial, non-self molecules is a critical event in the initiation of innate immune responses. This important function has been conserved throughout evolution from insects to humans (1–4). Several host cell surface receptors mediating this function have been identified.
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Molecular recognition of bacterial, non-self molecules is a critical event in the initiation of innate immune responses. This important function has been conserved throughout evolution from insects to humans (1–4). Several host cell surface receptors mediating this function have been identified.
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Annals of Allergy, Asthma & Immunology, 2002
To review the role of mammalian Toll-like receptors (TLRs) in host defense.MEDLINE search and current literature.First, TLRs participate in the recognition of molecular patterns present on microorganisms. Second, TLRs are expressed at the interface with the environment, the site of microbial invasion.
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To review the role of mammalian Toll-like receptors (TLRs) in host defense.MEDLINE search and current literature.First, TLRs participate in the recognition of molecular patterns present on microorganisms. Second, TLRs are expressed at the interface with the environment, the site of microbial invasion.
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, 2015 Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
exaly