Results 21 to 30 of about 396,801 (209)

The phosphoproteome of toll‐like receptor‐activated macrophages

Molecular Systems Biology, 2010
Recognition of microbial danger signals by toll‐like receptors (TLR) causes re‐programming of macrophages. To investigate kinase cascades triggered by the TLR4 ligand lipopolysaccharide (LPS) on systems level, we performed a global, quantitative and ...
Gabriele Weintz, Jesper V Olsen, Katja Frühauf, Magdalena Niedzielska, Ido Amit, Jonathan Jantsch, Jörg Mages, Cornelie Frech, Lars Dölken, Matthias Mann, Roland Lang   +10 more
doaj   +1 more source

Toll-like receptor signaling pathways

Frontiers in Immunology, 2014
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the
Taro eKawai, Takumi eKawasaki
doaj   +1 more source

Identification of single nucleotide polymorphisms in Toll-like receptor candidate genes associated with tuberculosis infection in water buffalo (Bubalus bubalis) [PDF]

, 2014
Toll-like receptors play a key role in innate immunity by recognizing pathogens and activating appropriate responses. Pathogens express several signal molecules (pathogen-associated molecular patterns, PAMPs) essential for survival and pathogenicity ...
Acutis, Pier Luigi, Alfano, Flora, BARONE, AMALIA, Borriello, Giorgia, Desiato, Rosanna, Galiero, Giorgio, Lucibelli, Maria Gabriella, Maniaci, Maria Grazia, Pasquali, Paolo, Peletto, Simone, Tarantino, Michela, Urciuolo, Giovanna   +11 more
core   +1 more source

Immunological study of orthodontically treated patients recovering from COVID-19 in Babylon Province, Iraq

Medical Journal of Babylon, 2023
Background and Objectives: This study aimed to examine the levels of the toll-like receptors TLR4 and TLR2 in the blood and saliva of patients with coronavirus disease-2019 (COVID-19) receiving orthodontic care in Babylon Province. Materials and Methods:
Basma Abdel Khaleq Eidan, Thaer Jaber Al-Khafaji, Ahmed Mohammed Abbas   +2 more
doaj   +1 more source

Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts [PDF]

, 2015
Surgical attenuation of a congenital portosystemic shunt (CPSS) results in increased portal vein perfusion, liver growth and clinical improvement. Portal lipopolysaccharide (LPS) is implicated in liver regeneration via toll-like receptor (TLR) 4 mediated
House, A K, Lipscomb, V J, Smith, K C, Tivers, M S, Wheeler-Jones, C P D   +4 more
core   +4 more sources

Toll-like receptor 2 and Toll-like receptor 4 predict favorable prognosis in local pancreatic cancer

Tumor Biology, 2018
Toll-like receptors play an essential role in our innate immune system and are a focus of interest in contemporary cancer research. Thus far, Toll-like receptors have shown promising prognostic value in carcinomas of the oral cavity, colon, and ovaries ...
Mira A Lanki, Hanna E Seppänen, Harri K Mustonen, Camilla Böckelman, Anne T Juuti, Jaana K Hagström, Caj H Haglund   +6 more
doaj   +1 more source

Toll-like receptor (TLR) 2 and TLR4 gene expression in canine heart [PDF]

, 2007
Toll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic.
Blecha, Frank, Linde, Annika, Melgarejo, Tonatiuh   +2 more
core   +2 more sources

Drift, not selection, shapes toll-like receptor variation among oceanic island populations [PDF]

, 2015
Understanding the relative role of different evolutionary forces in shaping the level and distribution of functional genetic diversity among natural populations is a key issue in evolutionary and conservation biology.
Acevedo-Whitehouse, Aguilar, Akira, Alcaide, Areal, Basu, Belvin, Betrán, Bollmer, Cabe, Chen, Cramp, Downing, Ekblom, England, Excoffier, Fornůsková, Frankham, Frankham, Garza, Gautschi, Girard, Goslee, Grueber, Grueber, Grueber, Grueber, Hall, Hartl, Hartmann, Hedrick, Hudson, Hughes, Illera, Jensen, Jiggins, Kalinowski, Keestra, Klein, Kryazhimskiy, Librado, Manly, Mikami, Miller, Misch, Murrell, Murrell, Nakajima, Ohta, Oliver, Outlaw, Piertney, Poltorak, Pond, Pond, Quéméré, R Development Core Team, Raymond, Richardson, Roach, Schröder, Sommer, Spurgin, Spurgin, Spurgin, Spurgin, Stephens, Sutton, Takeuchi, Tamura, Teacher, Trowsdale, Tschirren, Tschirren, Turner, Voelker, Winternitz, Wlasiuk, Yoneyama   +78 more
core   +2 more sources

Toll-like receptors as adjuvant receptors

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2002
The mammalian Toll-like receptors (TLRs) are expressed on macrophages and dendritic cells, which are primarily involved in innate immunity. At present, ligands for several of the TLRs, such as TLR2, TLR3, TLR4, TLR5, TLR6, and TLR9, have been identified.
Kaisho, Tsuneyasu, Akira, Shizuo
openaire   +2 more sources

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. [PDF]

, 2017
Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown.
Brennan, Cameron W., Campos, Carl, Clark, Owen, Codega, Paolo, DeAngelis, Lisa M., Dogan, Ahmet, Gavrilovic, Igor T., Glass, Jon, Graeber, Thomas G., Grommes, Christian, Gutin, Philip H., Hamlin, Paul, Hatzoglou, Vaios, Hsieh, Wan-Ying, Huse, Jason T., Kaley, Thomas J., Lallana, Enrico C., Mellinghoff, Ingo K., Moskowitz, Craig H., Nichol, Donna, Nolan, Craig P., Noy, Ariela, Omuro, Antonio, Palaskas, Nicolaos, Palomba, M. Lia, Panageas, Katherine S., Pastore, Alessandro, Peak, Scott, Pentsova, Elena, Reiner, Anne S., Rohle, Dan, Rosenblum, Marc, Sauter, Craig S., Schartz, Derrek, Schultz, Nikolaus, Tabar, Viviane S., Tang, Sarah S., Thomas, Alissa A., Tsyvkin, Elina, Viale, Agnes, Wolfe, Julia, Won, Minhee   +41 more
core   +2 more sources