Results 41 to 50 of about 5,866,745 (304)

Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor [PDF]

, 2011
Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen.
Saralili Dipa Robertson, Sofat, N, Nidhi Sofat, Wait, R, Robertson, SD, Wait, Robin, Robin Wait   +6 more
core   +1 more source

Ulvan Activates Chicken Heterophils and Monocytes Through Toll-Like Receptor 2 and Toll-Like Receptor 4

Frontiers in Immunology, 2018
Responsiveness to invasive pathogens, clearance via the inflammatory response, and activation of appropriate acquired responses are all coordinated by innate host defenses.
Nathalie Guriec, Frédérick Bussy, Christelle Gouin, Olivier Mathiaud, Benoit Quero, Matthieu Le Goff, Pi Nyvall Collén   +6 more
doaj   +1 more source

Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction. [PDF]

, 2011
Innate immune activation via IL-1R or Toll-like receptors (TLR) contibutes to acute kidney injury but its role in tissue remodeling during chronic kidney disease is unclear.
Skuginna Veronika, Mantovani Alberto, S. Clauss, Heni Eka Susanti, R. Allam, Skuginna, Veronika, Clauss, Sebastian, Susanti, Heni Eka, Ramanjaneyulu Allam, H. E. Susanti, Hans-Joachim Anders, Christoph Römmele, Sebastian Clauss, M. Lech, Veronika Skuginna, Clauss Sebastian, Cecilia Garlanda, Lech, Maciej, Ryu, Mi, Lech Maciej, Garlanda Cecilia, C. Garlanda, Ryu Mi, Römmele, Christoph, Heni Eka, Mantovani, Alberto, Alberto Mantovani, Anders Hans-Joachim, Allam Ramanjaneyulu, Maciej Lech, Cecilia Garl, M. Ryu, Susanti Heni Eka, A. Mantovani, Anders, Hans-Joachim, Mi Ryu, Allam, Ramanjaneyulu, Römmele Christoph, C. Römmele, H. J. Anders, Garlanda, Cecilia, V. Skuginna   +41 more
core   +1 more source

Decreased Toll-like Receptor (TLR) 2 and 4 Expression in Spermatozoa in Couples with Unexplained Recurrent Spontaneous Abortion (URSA)

Iranian Journal of Allergy, Asthma and Immunology, 2019
Studies have shown that toll-like receptors (TLRs) play some important roles in reproductive processes such as ovulation, spermatogenesis, sperm capacitation, fertilization, and pregnancy to the best of our knowledge, no study has evaluated the ...
Nasrin Sereshki, Alireza Andalib, Ataollah Ghahiri, Ferdos Mehrabian, Roya Sherkat, Abbas Rezaei   +5 more
doaj   +1 more source

Toll-like receptor 4 promotes proliferation and apoptosis resistance in human papillomavirus–related cervical cancer cells through the Toll-like receptor 4/nuclear factor-κB pathway

Tumor Biology, 2017
Toll-like receptor 4 is overexpressed in various tumors, including cervical carcinoma. However, the role of Toll-like receptor 4 in cervical cancer remains controversial, and the underlying mechanisms are largely elusive.
Ninghong Jiang, Feng Xie, Qisang Guo, Ming-Qing Li, Jingjing Xiao, Long Sui   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Clinical and Genetic Aspects of Chronic Pyelonephritis in Children: the Structure of Addiction and Primary Prognosis

Zdorovʹe Rebenka, 2013
Currently studying the mechanisms of recognition of foreign agents, which is implemented by Toll-like receptor of innate immune system, has become one of the main tasks of clinical immunology.
T.O. Kryuchko, V.P. Ostapenko, T.V. Kushnereva   +2 more
doaj   +1 more source

Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection [PDF]

, 2003
Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection.
Maskell, Duncan J, Foster, Neil, Tötemeyer, Sabine, Kaiser, Pete, Bryant, Clare E   +4 more
core  

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
McGivern, David R., Fengyu Hu, Daisuke Yamane (206804), David R McGivern, Hu, Fengyu, Hiromichi Dansako (357935), Nobuyuki Kato (235685), Christoph Welsch (22852), Stanley M. Lemon (30543), Daisuke Yamane, Christoph Welsch, Welsch, Christoph, David R. McGivern (415119), Lemon, Stanley M., Kato, Nobuyuki, Fengyu Hu (415120), Dansako, Hiromichi, Stanley M Lemon, Yamane, Daisuke, Nobuyuki Kato, Hiromichi Dansako   +20 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source