Results 71 to 80 of about 393,653 (192)

MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling

Journal of Hematology & Oncology, 2012
The discovery of miRNAs has revolutionized the way we examine the genome, RNA products, and the regulation of transcription and translation. Their ability to modulate protein expression through mRNA degradation and translation repression resulted in avid
Virtue Anthony, Wang Hong, Yang Xiao-feng   +2 more
doaj   +1 more source

Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer [PDF]

, 2013
OBJECTIVES: Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy.
Almeida, Joaquim Soares de, Bueno, Valquiria, Gomes, Guiomar Nascimento, Hirata, Aparecida Emiko, Teixeira, Daniela, Visniauskas, Bruna   +5 more
core   +5 more sources

TOLL LIKE RECEPTOR 4 (TLR4) AND DEMYELINATION

IBRO Neuroscience Reports, 2023
Estefanía Sánchez-Jiménez, Beatriz Fernández-Gómez, Esther Magan, Emma Muñoz-Sáez, Alba Macias, María Martín, David Piñeiro, Macarena Hernández-Jiménez, Alfonso Lagares, Luis Ley, Celia Oreja-Guevara, Fernando De Castro, Miguel Marchena   +12 more
doaj   +1 more source

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

Sequence variants of toll like receptor 4 and late-onset Alzheimer's disease.

PLoS ONE, 2012
BackgroundToll like receptor 4 (TLR4) has been related to inflammation and beta-amyloid deposition in Alzheimer's disease (AD) brain. No study has explored the association between haplotype-tagging single nucleotide polymorphisms (htSNPs) of TLR4 and AD ...
Yen-Ching Chen, Ping-Keung Yip, Yi-Ling Huang, Yu Sun, Li-Li Wen, Yi-Min Chu, Ta-Fu Chen   +6 more
doaj   +1 more source

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog [PDF]

, 2009
Alcohol synergistically enhances the progression of liver disease and the risk for liver cancer caused by hepatitis C virus (HCV). However, the molecular mechanism of this synergy remains unclear.
Asahina, Kinji, Deshaies, Raymond, Duan, Lewei, Dynnyk, Alla, Govindarajan, Sugantha, Lai, Michael M.-C., Liu, Helene Minyi, Machida, Keigo, Miyake, Kensuke, Mkrtchyan, Hasmik, Ou, Jing-hsiung James, Ray, Ratna, Seki, Ekihiro, Tsukamoto, Hidekazu   +13 more
core   +2 more sources

Toll‐like receptor 4 polymorphisms in Saudi population with cardiovascular diseases

Molecular Genetics & Genomic Medicine, 2019
Background Toll‐like receptors play a substantial role in innate immunity and the effects of TLR4 genetic variants on cardiovascular diseases are still largely unknown.
Abdelhabib Semlali, Mikhlid Al Mutairi, Ibrahim Oqla Alanazi, Hasan Awad Aljohi, Narasimha Reddy Parine, Abdullah Alhadheq, Abdulaziz A. Al‐Jafari, Abdulelah F. Mobeirek, Abdullah Al Amri, Jilani P. Shaik, Fatima‐zohra Filali, Mohammad Alanazi   +11 more
doaj   +1 more source

Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenic significance in specific subsets of patients

Haematologica, 2011
Background Signaling through the B-cell receptor appears to be a major contributor to the pathogenesis of chronic lymphocytic leukemia. Toll-like receptors bridge the innate and adaptive immune responses by acting as co-stimulatory signals for B cells ...
Eleni Arvaniti, Stavroula Ntoufa, Nikos Papakonstantinou, Tasoula Touloumenidou, Nikolaos Laoutaris, Achilles Anagnostopoulos, Klea Lamnissou, Federico Caligaris-Cappio, Kostas Stamatopoulos, Paolo Ghia, Marta Muzio, Chrysoula Belessi   +11 more
doaj   +1 more source

Hypoallergenic fragment of Par j 2 increases functional expression of Toll-like receptors in atopic children [PDF]

, 2006
Parietaria judaica (Par j) is one of the main causes of allergy in the Mediterranean countries. The activation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) inhibits nasal inflammation of atopic ...
Bonsignore, G, Bousquet, J, Bruno, A, Duro, G, Ferraro, M, Gjomarkaj, M., LA GRUTTA, Stefania, Pace, E   +7 more
core   +1 more source

Toll‐like receptor expression during inflammatory processes in human diseases

Rheumatology & Autoimmunity
Multi‐cellular organisms, including humans, have evolved immune systems as defense mechanisms against pathogens. The immune system employs the Toll‐like receptor (TLR) family as its primary defensive mechanism against infections.
Prashant K. Dhakad, Raghav Mishra, Isha Mishra   +2 more
doaj   +1 more source