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The Role of High-Mobility Group Box 1/Toll-Like Receptor 4 in Pericardial Fibrosis and Postoperative Low Cardiac Output Syndrome in Constrictive Pericarditis. [PDF]

Cardiol Res
Fang LK, Wang TX, Zhong FM, Yu GC, Li WH.   +4 more
europepmc   +1 more source

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Toll-like receptors, cytokines and HIV-1

Experimental and Molecular Pathology, 2008
The present investigation examined variations in cytokine and Toll-like receptor expression by T-lymphocytes in HIV infection. 50 HIV cases and 10 normal controls were evaluated for TLR3, TLR4, TLR8, TLR9, IL-2, IL-4, IL-6, IL-10, IL-12, TNF-alpha, and IFN-gamma expression and staining intensities. TLR3 was expressed in 37 HIV (74%) cases, and TLR4 was
Catherine M, Sanders, Julius M, Cruse, Robert E, Lewis   +2 more
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Immunohistochemical localization of Toll‐like receptors 1–10 in periodontitis

Oral Microbiology and Immunology, 2008
Background/aim:  In periodontitis, bacteria and pathogen‐associated molecular patterns are sensed by Toll‐like receptors (TLRs), which initiate intracellular signaling cascades that may lead to host inflammation. In this study, the expression and distribution of TLRs (TLR‐1 to TLR‐10) were immunohistochemically detected in gingival epithelium and ...
Beklen, A., Hukkanen, M., Richardson, R.; id_orcid 0000-0002-1071-6040, Konttinen, Y. T.   +3 more
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Toll‐like Receptor and RIG‐1‐like Receptor Signaling

Annals of the New York Academy of Sciences, 2008
Toll‐like receptors (TLRs) and RIG‐I‐like receptors (RLRs) constitute distinct families of pattern‐recognition receptors that sense nucleic acids derived from viruses and trigger antiviral innate immune responses. TLR3, TLR7, and TLR9 are membrane proteins localized to the endosome that recognize viral double‐stranded RNA, single‐stranded RNA, and DNA,
Taro Kawai, Shizuo Akira
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Interleukin-1 Receptor/Toll-Like Receptor Signaling

2007
Upon stimulation Interleukin-1 receptor (IL-1R), the related IL-18R as well as the Toll-like receptors (TLRs), trigger signaling pathways that activate the transcription factors, nuclear factor κB (NF-κB), activator protein 1 (AP1) and interferon regulatory factor 3 (IRF-3).
Harald Wajant, Peter Scheurich, Frank Henkler   +2 more
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Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

Nature Immunology, 2003
Interleukin 1 receptor (IL-1R) and Toll-like receptors (TLRs) induce inflammatory genes through the complex of MyD88, IL-1R-associated protein kinase (IRAK) and tumor necrosis factor receptor-associated factor 6 (TRAF6), which is believed to function 'upstream' of the cascades of IkappaB kinase (IKK) and nuclear factor-kappaB (NF-kappaB); extracellular
Qiaojia, Huang, Jianhua, Yang, Yong, Lin, Christopher, Walker, Jinke, Cheng, Zheng-gang, Liu, Bing, Su   +6 more
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SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

Nature Immunology, 2003
The Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily is important in differentially recognizing pathogen products and eliciting appropriate immune responses. These receptors alter gene expression, mainly through the activation of nuclear factor-kappaB and activating protein 1.
David, Wald, Jinzhong, Qin, Zhendong, Zhao, Youcun, Qian, Mayumi, Naramura, Liping, Tian, Jennifer, Towne, John E, Sims, George R, Stark, Xiaoxia, Li   +9 more
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A novel negative regulator for IL-1 receptor and Toll-like receptor 4

Immunology Letters, 2005
The Toll-IL-1 receptor (TIR) superfamily, defined by the presence of an intracellular TIR domain, initiates innate immunity via NF-kappaB activation, leading to production of proinflammatory cytokines. ST2 is a member of the TIR family that does not activate NF-kappaB and has been suggested as an important effector molecule of type 2 T helper cell ...
Foo Y, Liew, Haiying, Liu, Damo, Xu
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