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Toll-Like Receptors and Type 1 Diabetes
2010Type 1 diabetes (T1D) is an autoimmune disease that results in the progressive loss of insulin producing cells. Studies performed in humans with T1D and animal models of the disease over the past two decades have suggested a key role for the adaptive immune system in disease mechanisms.
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The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress
Immunological Reviews, 2008Summary: The interleukin‐1 receptor (IL‐1R)/Toll‐like receptor (TLR) superfamily was first defined in 1998 as a family of proteins that contain the Toll‐IL‐1 receptor domain. At that time, there were a number of orphan receptors in the IL‐1R branch, and the TLRs had yet to be shown to be key innate immune receptors that sense microbial products.
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Suppression of osteoblast toll‐like receptor 2 signaling by endothelin‐1
Journal of Orthopaedic Research, 2014ABSTRACTPeripheral endothelin‐1 (ET‐1) levels are increased in chronic systemic disorders such as congestive cardiac failure, diabetes and chronic renal failure. Bone infections are also associated with poor prognoses in these conditions. In the present study, we examined the alterations in Toll‐like receptor 2 (TLR2) signaling induced by ET‐1 in an in
Ai, Suzaki +2 more
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Toll-Like Receptors, Interleukin 1 and NFκB
2014Toll-like receptors (TLR) constitute a family of receptors involved in immune and inflammatory processes, which recognise molecules derived from infectious agents (bacteria, viruses) and endogenous substances. They are studied in this chapter together with interleukin 1 (IL1) and its receptors (IL1R) and with related interleukins such as IL18 and IL33,
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Molecular cloning and characterization of Toll-like receptors 1-10 in sheep
Veterinary Immunology and Immunopathology, 2009Toll-like receptors (TLRs) are pattern-recognition receptors that trigger innate immune responses and stimulate adaptive immunity. Currently, only partial information is available for sheep TLR genes. The aims of this study were to clone and sequence the coding regions of all 10 ovine TLR genes and compare the sequences with those of other mammalian ...
Jung-Su, Chang +5 more
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Toll-like Receptor 2 and Type 1 Diabetes
Science's STKE, 2007Clearance of apoptotic cells by phagocytosis helps prevent the leakage of cellular contents that may stimulate inflammation or autoimmunity. Nonobese diabetic (NOD) mice develop type I diabetes (T1D) because of the impaired phagocytosis of apoptotic pancreatic β cells by macrophages; however the mechanism involved is unclear. Kim
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Immunology Today, 2000
Abstract The interleukin 1 toll-like receptor superfamily is an expanding family of receptors, functioning as a rapid defense response to infection and injury, and possibly having other roles in human disease.
L A, O'Neill, C A, Dinarello
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Abstract The interleukin 1 toll-like receptor superfamily is an expanding family of receptors, functioning as a rapid defense response to infection and injury, and possibly having other roles in human disease.
L A, O'Neill, C A, Dinarello
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TOLL-LIKE RECEPTORS AND BRONCHIAL ASTHMA: PART 1
Transbaikalian Medical BulletinBronchial asthma is a chronic disease of the respiratory tract, which is formed by the action of endogenous factors and environmental influences. At the same time, T-helpers of the second type play a major role in the development of bronchial asthma, causing hyperreactivity and inflammation of the respiratory tract.
А. А. Mineeva +2 more
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Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
Nature Medicine, 2003The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted toward Mycobacterium leprae. TLR2-TLR1 heterodimers mediated cell activation by killed M. leprae, indicating the presence of triacylated lipoproteins.
Krutzik, Stephan R +15 more
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The Role of Toll-Like Receptor Pathways in the Mechanism of Type 1 Diabetes
Current Molecular Medicine, 2009Toll-like receptors (TLRs) and the innate immune system play a key role in sensing and eliminating microbial infections. Interactions between TLRs and their ligands expressed by microbial pathogens induce a cascade of intracellular signaling events, culminating in the upregulation of proinflammatory pathways. Over the past two decades, numerous studies
Egil, Lien, Danny, Zipris
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