Results 61 to 70 of about 34,084,722 (297)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Microbiota regulates type 1 diabetes through Toll-like receptors [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Commensal microbes affect autoimmunity, but it is not clear how. Type 1 diabetes is an organ-specific autoimmune disorder, and it too can be influenced by commensal microbiota. However, the complexity of the microbiota makes it difficult to connect specific microbes with disease progression or prevention.
Michael P, Burrows, Pavel, Volchkov, Koichi S, Kobayashi, Alexander V, Chervonsky   +3 more
openaire   +2 more sources

Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review

Revista da Sociedade Brasileira de Medicina Tropical
Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual’s susceptibility to ...
Daiane de Oliveira Cunha, Jacqueline Andréia Bernardes Leão-Cordeiro, Hellen da Silva Cintra de Paula, Fábio Silvestre Ataides, Vera Aparecida Saddi, Cesar Augusto Sam Tiago Vilanova-Costa, Antonio Márcio Teodoro Cordeiro Silva   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. [PDF]

, 2015
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is ...
Martina Svensson, Osman, AM, Salomonsson, E, Oliva Martín, María José, Annette Persson, Burguillos García, Miguel Ángel, Garcia-Quintanilla, Albert, Nikenza Viceconte, Englund, Elisabet,, Schulte, Tim, Elisabet Englund, Schulte, Tim,, Albert Garcia-Quintanilla, Kavanagh, Edel, Ahmed Mohamed Osman, Santiago, M, Joseph, Bertrand, García-Quintanilla, Alberto, Amar, Lahouari, Deierborg, Tomas,, Persson, A, Venero, Jose Luis, Blomgren, Klas, Englund, E, Leffler, H, Jose Luis Venero, Boza Serrano, Antonio, Burguillos, MA, García Quintanilla, Alberto, Martiniano Santiago, Antonio Boza-Serrano, Hakon Leffler, Joseph, B, Deierborg, Tomas, Englund, Elisabet, Persson, Annette,, Amar, L, Edel Kavanagh, Kavanagh, E, Lund University., Leffler, Hakon,, Emma Salomonsson, Venero, JL, Boza Serrano, Antonio,, Santiago, Martiniano, Venero Recio, José Luis, Amar, Lahouari,, Kavanagh, Edel T., Oliva-Martín, María J., Blomgren, K, Svensson, Martina,, Miguel Angel Burguillos, Viceconte, Nikenza, Bertrand Joseph, Salomonsson, Emma,, Oliva-Martin, Maria Jose, Svensson, Martina, Tim Schulte, Maria Jose Oliva-Martin, Osman, Ahmed Mohamed, Oliva-Martin, MJ, Boza-Serrano, A, Salomonsson, Emma, Persson, Annette, Achour, A, Garcia-Quintanilla, A, Adnane Achour, Achour, Adnane, Burguillos Garcia, Miguel, Viceconte, N, Burguillos Garcia, Miguel,, Santiago Pavón, Martiniano, Schulte, T, Tomas Deierborg, Svensson, M, Venero, José L., Klas Blomgren, Lahouari Amar, Deierborg, T, Burguillos, Miguel Angel, Leffler, Hakon, Boza-Serrano, Antonio   +81 more
core   +1 more source

Interleukin-1/Toll-like receptor signaling potentiates macrophage olfactory receptor 2-driven atherosclerosis

Cell Reports
Summary: Olfactory receptor 6A2 (OR6A2) signaling stimulates atherogenic NLRP3 inflammasome activation in vascular macrophages (Mϕs). Current evidence suggests that interleukin-1 receptor type 1 (IL-1R1)/Toll-like receptor (TLR) signaling may modulate ...
Lujun Zhang, Jili Fu, Zicheng Hu, Yunli Zhao, Yu Cao, Mengyu Yao, Fan Liu, Jianlin Du, Haitao Ran, Zhigang Wang, Yongyong Li, Liwen Liang, Wenhua Su, Narayan D. Melgiri, Dongfang Liu, Lihong Jiang, Tianyang Hu, Rongzhong Huang, Yang Sun   +18 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state [PDF]

, 2001
Background: Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many inflammation associated genes.
Aderem, A, Underhill David M, Ozinsky, A O, Underhill, D. M., Ozinsky, A.O., Sweet Matthew J, Hume, D A, Liew Foo Y, Sweet, M J, Underhill, D M, Liew, F Y, Liew, F.Y., Aderem, A., Sweet, M. J., Hume, D. A., Hume David A, Ozinsky Adrian O, Aderem Alan   +17 more
core   +1 more source

Regulation by Nrf2 of IL-1β-induced inflammatory and oxidative response in VSMC and its relationship with TLR4

Frontiers in Pharmacology, 2023
Introduction: Vascular oxidative stress and inflammation play an important role in the pathogenesis of cardiovascular diseases (CVDs). The proinflammatory cytokine Interleukin-1β (IL-1β) participates in the vascular inflammatory and oxidative responses ...
Zoe González-Carnicero, Raquel Hernanz, Raquel Hernanz, Marta Martínez-Casales, María Teresa Barrús, Ángela Martín, Ángela Martín, María Jesús Alonso, María Jesús Alonso   +8 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source