Results 141 to 150 of about 213,803 (247)

The role of mediator suppressor of cytokine signaling (SOCS), toll-like receptor 3 (TLR-3) and nuclear factor kappa B (NFκB) on cytokine production during dengue virus infection. [PDF]

Narra J, 2023
Masyeni S, Kuntaman K, Aryati A, Sofro MA, Hadi U, Mastutik G, Purnomo W, Santosa A, Iqhrammullah M, Yohan B, Nelwan EJ, Sasmono RT.   +11 more
europepmc   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

A Phase Ib Study of Indirect Immunization with Oregovomab and Toll-like-Receptor-3 Stimulation with Hiltonol^® in Patients with Recurrent Platinum-Resistant Ovarian Cancer. [PDF]

Curr Oncol
Holloway RW, Temkin SM, Gordon SW, Gupta S, Jada SR, Ahmad S, McGuire WP.   +6 more
europepmc   +1 more source

COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like receptor 3? [PDF]

Vascul Pharmacol, 2021
Dela Justina V, Giachini FR, Priviero F, Webb RC.   +3 more
europepmc   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Late-Stage Activation of Toll-like receptor 3 Alleviates Cognitive Impairment and Neuropathology in an Alzheimer's Disease Mouse Model. [PDF]

Mol Neurobiol
Zhu T, Shen F, Jia X, Zhou H, Ni W, Wang S, Wu D, Gao H, Shang Z, Zhou Y, Han J, Jin G, Dong F, Zu J, Yang X, Shi H, Zhou C, Hua F.   +17 more
europepmc   +1 more source

Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite <i>Leishmania (Leishmania) amazonensis</i>. [PDF]

Infect Immun, 2022
Rath CT, Vivarini ÁC, Dos Santos JV, Medina JM, Saliba AM, Mottram JC, Lima APCA, Calegari-Silva TC, Pereira RM, Lopes UG.   +9 more
europepmc   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Inhibition of Toll-Like Receptor 3 Relieves Osteoarthritis by Suppression of Cartilage Degradation, Nuclear Factor Kappa B-Mediated Inflammation, and Activation of Autophagy. [PDF]

Cartilage
Hou Z, Wang M, Cao S.
europepmc   +1 more source

CD40; toll-like receptor 3 (TLR3); TLR4 [PDF]

Science-Business eXchange, 2011
openaire   +1 more source