Results 71 to 80 of about 349,446 (189)
Toll-like receptor (TLR) 2 and TLR4 gene expression in canine heart [PDF]
, 2007 Toll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic.
Blecha, Frank +2 more
core +2 more sources
A proteomic analysis of serum-derived exosomes in rheumatoid arthritis
BMC Rheumatology, 2018 Background To understand the roles of serum exosomes in rheumatoid arthritis (RA), we comprehensively investigated the protein profiles of serum exosomes in patients with RA. Methods Exosomes were isolated from serum samples obtained from 33 patients (12
Hirotaka Tsuno +11 more
doaj +1 more source
In search of the Aplysia immunome: an in silico study
BMC Genomics, 2022 The immune repertoires of mollusks beyond commercially important organisms such as the pacific oyster Crassostrea gigas or vectors for human pathogens like the bloodfluke planorb Biomphalaria glabrata are understudied.
Nicholas S. Kron
doaj +1 more source
mRNA Is an Endogenous Ligand for Toll-like Receptor 3 [PDF]
Journal of Biological Chemistry, 2004 Toll-like receptors (TLRs) are the basic signaling receptors of the innate immune system. They are activated by molecules associated with pathogens or injured host cells and tissue. TLR3 has been shown to respond to double stranded (ds) RNA, a replication intermediary for many viruses.
Katalin, Karikó +4 more
openaire +2 more sources
Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]
, 2014 Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core +1 more source
Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]
, 2020 Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P. +7 more
core +2 more sources
Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes
Frontiers in Cellular Neuroscience, 2020 TLR3 provides immediate type I IFN response following entry of stimulatory PAMPs into the CNS, as it is in HSV infection. The receptor plays a vital role in astrocytes, contributing to rapid infection sensing and suppression of viral replication ...
Matylda B. Mielcarska +11 more
doaj +1 more source
Emerging targets in human lymphoma: targeting the MYD88 mutation [PDF]
, 2016 B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link ...
Horikawa, Keisuke +2 more
core +1 more source
Dual Role of Host Toll-Like Receptor 3 in Parasitic Diseases
Frontiers in Bioscience-LandmarkParasitic diseases, caused by a diverse array of parasites, remain a substantial threat to global health. Toll-like receptor 3 (TLR3) represents a pivotal element in the innate immune system, distinguished by an ability to signal via the TIR-domain ...
Yixin Yang +4 more
doaj +1 more source
OncoImmunology, 2019 Toll-like receptor 3 (TLR3) is a receptor recognizing double-stranded RNA (dsRNA) from viruses as well as from lytic mammalian cells. In the present study, we performed a two-stage association study (n = 3,551) and found that the minor alleles of two ...
Lei Fan +6 more
doaj +1 more source