Results 21 to 30 of about 347,248 (305)

Sequence variants of toll like receptor 4 and late-onset Alzheimer's disease.

PLoS ONE, 2012
BackgroundToll like receptor 4 (TLR4) has been related to inflammation and beta-amyloid deposition in Alzheimer's disease (AD) brain. No study has explored the association between haplotype-tagging single nucleotide polymorphisms (htSNPs) of TLR4 and AD ...
Yen-Ching Chen, Ping-Keung Yip, Yi-Ling Huang, Yu Sun, Li-Li Wen, Yi-Min Chu, Ta-Fu Chen   +6 more
doaj   +1 more source

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

Nature Immunology, 2009
In atherosclerosis and Alzheimer's disease, deposition of the altered self components oxidized low-density lipoprotein (LDL) and amyloid-β triggers a protracted sterile inflammatory response.
C. Stewart, L. Stuart, K. Wilkinson, J. V. van Gils, Jiusheng Deng, A. Halle, K. Rayner, L. Boyer, Ruiqin Zhong, W. Frazier, A. Lacy-Hulbert, J. El Khoury, D. Golenbock, K. Moore   +13 more
semanticscholar   +1 more source

Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease

Mediators of Inflammation, 2022
Alzheimer's disease (AD) is a progressive neurodegenerative disease that primarily manifests as memory deficits and cognitive impairment and has created health challenges for patients and society.
Linyu Wu, X. Xian, Guangyu Xu, Zixuan Tan, Fang Dong, M. Zhang, Feng Zhang   +6 more
semanticscholar   +1 more source

Toll-like receptor 4 and atherogenesis

Annals of Medicine, 2003
Toll-like receptor 4 (TLR4) is a pattern recognition receptor involved in the innate immune response to various microorganisms and other exogenous and endogenous stress factors. Recently, evidence emerged that important inflammatory processes implicit in human atherogenesis are mediated in part via the TLR4/nuclear factor-kappaB pathway.
Stefan, Kiechl, Christian J, Wiedermann, Johann, Willeit   +2 more
openaire   +2 more sources

Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.

PLoS ONE, 2013
Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation. Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4.
Simon J Freeley, Angela Giorgini, Calogero Tulone, Reena J Popat, Catherine Horsfield, Michael G Robson   +5 more
doaj   +1 more source

Bacterial flagellin is a dominant, stable innate immune activator in the gastrointestinal contents of mice and rats

Gut Microbes, 2023
Intestinal contents comprise the largest repository of immunogenic ligands of microbial origin. We undertook this study to assess the predominant microbe-associated molecular patterns (MAMPs) present therein and the receptors) that mediate the innate ...
Matam Vijay-Kumar, Venugopal R. Bovilla, Beng San Yeoh, Rachel M. Golonka, Piu Saha, Bina Joe, Andrew T. Gewirtz   +6 more
doaj   +1 more source

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Cell, 2008
Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung ...
Y. Imai, K. Kuba, G. Neely, Rubina Yaghubian-Malhami, T. Perkmann, G. van Loo, M. Ermolaeva, R. Veldhuizen, Y. C. Leung, Hongliang Wang, Haolin Liu, Yang Sun, M. Pasparakis, M. Kopf, C. Mech, S. Bavari, J. Peiris, Arthur S Slutsky, S. Akira, M. Hultqvist, R. Holmdahl, J. Nicholls, Chengyu Jiang, C. Binder, J. Penninger   +24 more
semanticscholar   +1 more source

Toll‐like receptor 4 polymorphisms in Saudi population with cardiovascular diseases

Molecular Genetics & Genomic Medicine, 2019
Background Toll‐like receptors play a substantial role in innate immunity and the effects of TLR4 genetic variants on cardiovascular diseases are still largely unknown.
Abdelhabib Semlali, Mikhlid Al Mutairi, Ibrahim Oqla Alanazi, Hasan Awad Aljohi, Narasimha Reddy Parine, Abdullah Alhadheq, Abdulaziz A. Al‐Jafari, Abdulelah F. Mobeirek, Abdullah Al Amri, Jilani P. Shaik, Fatima‐zohra Filali, Mohammad Alanazi   +11 more
doaj   +1 more source

TOLL-LIKE RECEPTORS (TLR) 2 AND 4 EXPRESSION OF KERATINOCYTES FROM PATIENTS WITH LOCALIZED AND DISSEMINATED DERMATOPHYTOSIS

Revista do Instituto de Medicina Tropical de São Paulo, 2015
There are few studies on the role of innate immune response in dermatophytosis. An investigation was conducted to define the involvement of Toll-Like Receptors (TLRs) 2 and 4 in localized (LD) and
Cristiane Beatriz de Oliveira, Cídia Vasconcellos, Neusa Y. Sakai-Valente, Mirian Nacagami Sotto, Fernanda Guedes Luiz, Walter Belda JÚNIOR, Maria da Gloria Teixeira de Sousa, Gil Benard, Paulo Ricardo Criado   +8 more
doaj   +1 more source

Toll-like receptor 4 in COVID-19: friend or foe?

Future Virology, 2022
Tweetable abstract Toll-like receptor 4, an innate immune sensor, is one of the key ‘fate-deciding’ regulators of immunity as well as COVID-19 immunopathogenesis.
S. Mukherjee
semanticscholar   +1 more source