Results 61 to 70 of about 347,248 (305)

Clinical and Genetic Aspects of Chronic Pyelonephritis in Children: the Structure of Addiction and Primary Prognosis

Zdorovʹe Rebenka, 2013
Currently studying the mechanisms of recognition of foreign agents, which is implemented by Toll-like receptor of innate immune system, has become one of the main tasks of clinical immunology.
T.O. Kryuchko, V.P. Ostapenko, T.V. Kushnereva   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105 [PDF]

Nature Immunology, 2005
Activation of Toll-like receptor (TLR) signaling by microbial signatures is critical to the induction of immune responses. Such responses demand tight regulation. RP105 is a TLR homolog thought to be mostly B cell specific, lacking a signaling domain. We report here that RP105 expression was wide, directly mirroring that of TLR4 on antigen-presenting ...
Senad, Divanovic, Aurelien, Trompette, Sowsan F, Atabani, Rajat, Madan, Douglas T, Golenbock, Alberto, Visintin, Robert W, Finberg, Alexander, Tarakhovsky, Stefanie N, Vogel, Yasmine, Belkaid, Evelyn A, Kurt-Jones, Christopher L, Karp   +11 more
openaire   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Involvement of the visfatin/toll-like receptor 4 signaling axis in human dental pulp cell senescence: Protection via toll-like receptor 4 blockade

Journal of Dental Sciences, 2023
Background: /purpose: Dental pulp plays an important role in the maintenance of tooth homeostasis and repair. The aging of dental pulp affects the functional life of the tooth owing to the senescence of dental pulp cells.
Chang Youp Ok, Sera Park, Hye-Ock Jang, Moon-Kyoung Bae, Soo-Kyung Bae   +4 more
doaj   +1 more source

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4.

Cell, 2011
The transport of Toll-like Receptors (TLRs) to various organelles has emerged as an essential means by which innate immunity is regulated. While most of our knowledge is restricted to regulators that promote the transport of newly synthesized receptors ...
I. Zanoni, Renato Ostuni, Lorri R. Marek, S. Barresi, Roman Barbalat, G. Barton, F. Granucci, Jonathan C. Kagan   +7 more
semanticscholar   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Polymorphisms of toll-like receptor 2 and 4 genes in Chagas disease

Memorias do Instituto Oswaldo Cruz, 2008
The aim of this study was to test the possible implication of toll-like receptor 2 (TLR2) and TLR4 gene polymorphisms in determining the susceptibility to Chagas' disease. Genotypes were determined by polymerase chain reaction-restriction fragment length
German Zafra, Oscar Flórez, Carlos A. Morillo, Luis Eduardo Echeverría, Javier Martín, Clara Isabel González   +5 more
doaj   +1 more source

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4*

Journal of Biological Chemistry, 2001
Cellular fibronectin, which contains an alternatively spliced exon encoding type III repeat extra domain A (EDA), is produced in response to tissue injury.
Y. Okamura, M. Watari, Elliot S. Jerud, D. Young, S. Ishizaka, Jeffrey M. Rose, Jesse C. Chow, J. Strauss   +7 more
semanticscholar   +1 more source

Toll-Like Receptor 3 Mediates a More Potent Antiviral Response Than Toll-Like Receptor 4 [PDF]

The Journal of Immunology, 2003
Abstract We have recently described an IFN regulatory factor 3-mediated antiviral gene program that is induced by both Toll-like receptor (TLR)3 and TLR4 ligands. In our current study, we show that activation of IFN/viral response gene expression in primary macrophage cells is stronger and prolonged with TLR3 stimulation compared with ...
Sean E, Doyle, Ryan, O'Connell, Sagar A, Vaidya, Edward K, Chow, Kathleen, Yee, Genhong, Cheng   +5 more
openaire   +2 more sources