Results 111 to 120 of about 14,758,329 (299)

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Toll-like receptor 2-mediated ERK activation significantly upregulates interleukin-6 expression in M2-polarized macrophages

Türk Biyokimya Dergisi
M2-polarized macrophages and interleukin (IL)-6 significantly alter the tumor microenvironment and promote the malignant behaviors of tumor cells. This study aimed to establish M2-type macrophages from THP-1 cells, which are human leukemia monocytes, and
Jo Wol Soon, Kim Sung Dae, Jeong Soo Kyung, Oh Su Jung, Baik Ji Sue, Seo Ji An, Baek Jeong-Hwa, Lee Chang Geun, Kang Young-Rok, Jeong Min Ho, Park Moon-Taek   +10 more
doaj   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Sustained Toll-like receptor 9 activation promotes systemic and cardiac inflammation, and aggravates diastolic heart failure in SERCA2a KO mice [PDF]

, 2015
Aim Cardiac inflammation is important in the pathogenesis of heart failure. However, the consequence of systemic inflammation on concomitant established heart failure, and in particular diastolic heart failure, is less explored.
Sigve Dhondup Holmen (812740), Ahmed, Muhammad Shakil, Aronsen, Jan Magnus, Lili Zhang, Muhammad Shakil Ahmed (812741), Leif Erik Vinge (329788), Pål Aukrust (151370), Zhang, Lili, Øystein Sandanger (329789), Håvard Attramadal (224421), Helge Scott, Håvard Attramadal, Attramadal, Håvard, Arne Yndestad (224387), Sigve Dhondup Holmen, Holmen, Sigve, Sandanger, Øystein, Ivar Sjaastad, Lars Gullestad (224437), Pål Aukrust, Christensen, Geir Arve, Ivar Sjaastad (162165), Lili Zhang (120447), Muhammad Shakil Ahmed, Geir Christensen (162197), Haugstad, Solveig Bjærum, Dhondup, Yangchen, Yangchen Dhondup, Scott, Helge, Lars Gullestad, Yndestad, Arne, Gullestad, Lars, Sjaastad, Ivar, Yangchen Dhondup (812738), Helge Scott (4898), Trine Ranheim, Arne Yndestad, Solveig Bjærum Haugstad, Katrine Alfsnes (616207), Alfsnes, Katrine, Solveig Bjærum Haugstad (812739), Trine Ranheim (151364), Geir Christensen, Jan Magnus Aronsen, Katrine Alfsnes, Leif Erik Vinge, Vinge, Leif Erik, Jan Magnus Aronsen (347485), Ranheim, Trine, Aukrust, Pål, Øystein Sandanger   +50 more
core   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

The role of toll-like receptors in the adrenal gland [PDF]

, 2010
Sepsis is caused by infection and often followed by an overwhelming inflammatory response. This can lead to shock, organ failure and even death. Each year approximately 60,000 people die in Germany due to sepsis.
Tran, Thi Hoai Nguyen
core  

Hepatocyte growth factor as a driver of synovial inflammation and therapeutic resistance in rheumatoid arthritis

Frontiers in Immunology
BackgroundPrevious studies have demonstrated that hepatocyte growth factor (HGF) is implicated in treatment resistance in rheumatoid arthritis (RA).
Quang Minh Dang, Quang Minh Dang, Quang Minh Dang, Ryu Watanabe, Takeshi Iwasaki, Ryuhei Ishihara, Keiichiro Kadoba, Koichi Murata, Koichi Murata, Masao Tanaka, Hiromu Ito, Thanh Duc Tran, Thanh Duc Tran, Thanh Duc Tran, Sang Quang Tran Nguyen, Sang Quang Tran Nguyen, Sang Quang Tran Nguyen, Khanh Van Nguyen, Khanh Van Nguyen, Hongxin Sun, Masao Katsushima, Hui Zhang, Yutaro Yamada, Kenji Mamoto, Tadashi Okano, Tran Trung Dung, Tran Trung Dung, Le Thi Thanh Thuy, Le Thi Thanh Thuy, Motomu Hashimoto   +29 more
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Unravelling the anti-inflammatory mechanisms of dietary fatty acids [PDF]

, 2009
Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. The specific mechanisms of their actions have yet to be defined.
Dowling, Jennifer K.
core   +2 more sources

Toll-like receptor 2/6-dependent stimulation of mesenchymal stem cells promotes angiogenesis by paracrine factors [PDF]

European Cells & Materials, 2013
Reconstruction of critical size bone defects represents a major challenge in orthopaedic surgery. Insufficient angiogenesis is a limiting factor for engraftment of large-scale tissue transplants.
H Kokemüller, M Luchtefeld, S Spalthoff, P Jehn, C Liu, M Petri, K Grote, T Tschernig, C Krettek, C Haasper, M Jagodzinski   +10 more
doaj