Results 91 to 100 of about 14,758,329 (299)

Multivalent, Stabilized Mannose‐6‐Phosphates for the Targeted Delivery of Toll‐Like Receptor Ligands and Peptide Antigens

ChemBioChem, 2020
AbstractMannose‐6‐phosphate (M6P) is recognized by the mannose‐6‐phosphate receptor and plays an important role in the transport of cargo to the endosomes, making it an attractive tool to improve endosomal trafficking of vaccines. We describe herein the assembly of peptide antigen conjugates carrying clusters of mannose‐6‐C‐phosphonates (M6Po).
Niels R. M. Reintjens, Elena Tondini, Christopher Vis, Toroa McGlinn, Nico J. Meeuwenoord, Tim P. Hogervorst, Herman S. Overkleeft, Dmitri V. Filippov, Gijsbert A. van der Marel, Ferry Ossendorp, Jeroen D. C. Codée   +10 more
openaire   +4 more sources

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Candida albicans infection suppresses lipopolysaccharide or Pseudomonas aeruginosa stimulated murine bone marrow derived macrophage (BMDM) responses

Scientific Reports
Candida albicans is an opportunistic human pathogen, that commonly causes localised infection of mucosal surfaces. Candida can also cause systemic infections, which remain difficult to treat and have a high risk of mortality.
Christa P. Baker, Stephanie Laba, Jordan Warner, Karen Shepherd, Heather M. Wilson, J. Simon C. Arthur   +5 more
doaj   +1 more source

The Characterization of a New AG-II-like Glycoprotein from Cynanchum thesioides (Freyn) K. Schum and Its Immunostimulatory Activity Through Activation of TLR4/9-Mediated MAPK/NF-κB Signaling Pathways

Current Issues in Molecular Biology
The structural and immunomodulatory properties of arabinogalactan proteins (AGPs) from edible medicinal plants remain largely unexplored. Here, A homogenous AG-II-like arabinogalactan protein (CTSP-W2, 9862 Da) was isolated from Cynanchum thesioides via ...
Mu Dan, Peng Zhao, Lu Ga, Wenming Bai, Pengwei Zhao, Han Ge, Ruirui Wang, Surina Bo, Munkhtsetseg Baatar   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages [PDF]

, 2009
Background Toll-like receptors (TLRs) are present on monocytes and alveolar macrophages that form the first line of defense against inhaled particles.
Esmaeil Mortaz, Nijkamp, Frans P, Caldenhoven Eric, Caldenhoven, Eric, Kraneveld, Aletta D, Gert Folkerts, Sarir Hadi, Folkerts Gert, Nijkamp Frans P, Khalil Karimi, Kraneveld Aletta D, Karimi Khalil, Sarir, Hadi, Mortaz Esmaeil, Karimi, Khalil, Rahman Irfan, Folkerts, Gert, Frans P Nijkamp, Rahman, Irfan, Irfan Rahman, Eric Caldenhoven, Aletta D Kraneveld, Mortaz, Esmaeil, Hadi Sarir   +23 more
core   +1 more source

Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer

Clinics, 2013
OBJECTIVES: Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy.
Daniela Teixeira, Joaquim Soares de Almeida, Bruna Visniauskas, Guiomar Nascimento Gomes, Aparecida Emiko Hirata, Valquiria Bueno   +5 more
doaj  

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection [PDF]

, 2008
Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which causes altered responsiveness to the bacterial pathogens.
Rostislav Skrabana, Michal Novak, Mangesh Bhide, Ivan Mikula Jr., Rastislav Mucha, Lucia Kisova, Ivan Mikula Sr.   +6 more
core  

Common Variants of TLR1 Associate with Organ Dysfunction and Sustained Pro- Inflammatory Responses during Sepsis [PDF]

, 2010
Background: Toll-like receptors (TLRs) are critical components for host pathogen recognition and variants in genes participating in this response influence susceptibility to infections.
Pino Yanes, Maria, Antoni Torres, Zavala Elizabeth, Villar, Jesús, Jesús Villar, Ferrer Miguel, Jesús Blanco, Pino-Yanes Maria, Espinosa Elena, García Bello, Miguel, Miguel García-Bello, Milena Casula, Ferrer Monreal, Miquel, Torres Antoni, Muriel, Arturo, Arturo Muriel, Flores Carlos, Flores, Carlos, Carlos Flores, Blanco Jesús, Torres Martí, Antoni, Villar Jesús, Almudena Corrales, Elizabeth Zavala, Blanco, Jesús, García-Bello Miguel, Miguel Ferrer, Elena Espinosa, Maria Pino-Yanes, Espinosa, Elena, Casula Milena, null null, Zavala Zegarra, Elizabeth, Muriel Arturo, Casula, Milena, GRECIA and GEN-SEP Groups, Corrales Almudena, Corrales, Almudena, GEN-SEP groups   +38 more
core   +2 more sources