Results 71 to 80 of about 14,758,329 (299)

The Turkey Ig-like receptor family: identification, expression and function. [PDF]

, 2012
The chicken leukocyte receptor complex located on microchromosome 31 encodes the chicken Ig-like receptors (CHIR), a vastly expanded gene family which can be further divided into three subgroups: activating CHIR-A, bifunctional CHIR-AB and inhibitory ...
Windau, Katharina, Birgit C Viertlboeck, Birgit C. Viertlboeck, Thomas W Göbel, Thomas W. Göbel, Viertlboeck, Birgit C., Göbel, Thomas W. F., Katharina Windau   +7 more
core   +2 more sources

TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis

Jornal de Pediatria, 2014
Objective: To analyze toll-like receptor (TLR)-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis. Methods: This prospective study included 27 full-term newborns aged 8 to 29 days, with clinical and laboratory diagnosis of late-onset ...
Ana C.C. Redondo, Maria E.J.R. Ceccon, Ana L. Silveira-Lessa, Camila Quinello, Patrícia Palmeira, Werther B. Carvalho, Magda Carneiro-Sampaio   +6 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Lupeol alleviates coxsackievirus B3-induced viral myocarditis in mice via downregulating toll-like receptor 4

Journal of International Medical Research, 2020
Objectives To investigate the effect of lupeol in a mouse model of viral myocarditis induced by coxsackie virus B3 (CVB3). Methods Mice were separated into controls (DMEM, n  = 20) and CVB3 infected groups (i.e., untreated CVB3 [ n  = 40]; CVB3 + lupeol ...
Ming Xu, Xiaoyong Li, Laichun Song, Chao Tao, Jihui Fang, Liang Tao   +5 more
doaj   +1 more source

Interleukin-6 via Toll-Like Receptor 3 Signaling Attenuates the Expression of Proinflammatory Chemokines in Human Podocytes

Kidney & Blood Pressure Research, 2021
Background: Although toll-like receptor 3 (TLR3) signaling is involved in the development of certain chronic kidney diseases, the specific molecular mechanisms underlying inflammatory reactions via activation of TLR3 signaling in human podocytes remain ...
Hidenori Umetsu, Shojiro Watanabe, Tadaatsu Imaizumi, Tomomi Aizawa, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Hiroshi Tanaka   +8 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Immunomodulatory Effects of a Standardized Botanical Mixture Comprising Angelica gigas Roots and Pueraria lobata Flowers Through the TLR2/6 Pathway in RAW 264.7 Macrophages and Cyclophosphamide-Induced Immunosuppression Mice

Pharmaceuticals
Background: As the population ages, enhancing immune function is crucial to mitigating age-related physiological decline. Since immunostimulant drugs are known to have potential side effects, medicinal plants emerge as promising candidates offering a ...
Seo-Yun Jang, Hyeon-A Song, Min-Ji Park, Kyung-Sook Chung, Jong Kil Lee, Eun Yeong Jang, Eun Mi Sun, Min Cheol Pyo, Kyung-Tae Lee   +8 more
doaj   +1 more source

Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling

Cell Reports, 2015
Although dendritic cell (DC) dysfunction in cancer is a well-recognized consequence of cancer-associated inflammation that contributes to immune evasion, the mechanisms that drive this process remain elusive.
Michael Tang, Jun Diao, Hongtao Gu, Ismat Khatri, Jun Zhao, Mark S. Cattral   +5 more
doaj   +1 more source

Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases

Signal Transduction and Targeted Therapy, 2023
mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer and infectious diseases.
Yangzhuo Gu, Jingyun Yang, Cai He, Tingmei Zhao, Ran Lu, Jian Liu, Xianming Mo, Fuqiang Wen, Huashan Shi   +8 more
doaj   +1 more source

Immunomodulation by semi-mature dendritic cells: A novel role of Toll-like receptors and interleukin-6

International Journal of Medical Microbiology, 2010
Dendritic cells (DCs) are key players in activation of the adaptive immune system by their ability of antigen presentation to and priming of T cells. An increasing body of evidence suggests that DCs may also play an important role in induction of tolerance, predominantly by induction of regulatory T cells (T(reg)).
Julia-Stefanie, Frick, Frank, Grünebach, Ingo B, Autenrieth   +2 more
openaire   +2 more sources