Results 261 to 270 of about 14,758,329 (299)

Toll-like receptors 1, 2, 4, 5, and 6 in gastric cancer

Virchows Archiv, 2023
Toll-like receptors (TLRs) are expressed on both immune cells and tumor cells, triggering both anti-tumor and pro-tumor responses. Therefore, TLRs have potential as prognostic biomarkers and immunotherapeutic targets. The aim of this study was to investigate TLR1, TLR2, TLR4, TLR5, and TLR6 expression and association with clinicopathological variables ...
Maarit Eskuri, Niko Kemi, Olli Helminen, Heikki Huhta, Joonas H Kauppila   +4 more
openaire   +2 more sources

Variants of Toll-like receptor 6 associated with tuberculosis susceptibility in the Chinese Tibetan population

Microbial Pathogenesis, 2022
Our investigation attempted to understand the role of innate immunity related genes played in tuberculosis. The relationship between single-nucleotide polymorphisms (SNPs) of three innate immunity-related genes (TLR6, MyD88, and TIRAP) and tuberculosis (TB) risk in two Chinese populations were explored.Totally 1185 Chinese Han, consisting of 580 active
Miaomiao Zhang, Guo Chen, Jian-Qing He
openaire   +2 more sources

Expression of Toll-like receptors 2, 4 and 6 in the equine chorioallantois

Veterinary Immunology and Immunopathology, 2018
In mares, placental diseases are a common cause of pregnancy failure and they can have an economic impact on the horse breeding industry. To our knowledge no published data on TLR expression in the equine placenta exist. This study examined the expression of TLR 2, 4 and 6 as transcript and protein in the placenta (chorioallantois) of 14 foals born ...
Sandra, Schöniger, Hilke, Gräfe, Maritta, Wipplinger, Heinz-Adolf, Schoon   +3 more
openaire   +2 more sources

Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2

Journal of Dental Research, 2010
The osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and tumor necrosis factor-α (TNF-α).
Souza, Pedro Paulo Chaves de, Palmqvist, P., Lundgren, I., Lie, A., Costa-Neto, C. M., Lundberg, P., Lerner, U. H.   +6 more
openaire   +3 more sources

Toll-like receptors types 2 and 6 and the apoptotic process in human neutrophils

Archivum Immunologiae et Therapiae Experimentalis, 2006
Neutrophils (PMN) apoptosis plays an important role in limiting the last phase of inflammatory processes. It is unknown whether Toll-like receptor (TLR)2 acts independently or together with TLR6 in this process.The aim of this study was to estimate the relationship between the expressions of TLR2 and TLR6 and the apoptosis of human neutrophils in ...
Ewa, Jabłońska, Magdalena, Marcińczyk, Jakub, Jabłoński   +2 more
openaire   +3 more sources

Preparation of the Extracellular Domain of Recombinant Human Toll-like Receptor 6

The Protein Journal, 2017
Toll-like receptors (TLRs) mediate immune responses upon recognition of a variety of ligands. To further elucidate the function of TLRs, it is important to identify novel ligands and their action mechanisms including polymer assembly. In this study, we propose an efficient method for preparation of the extracellular domain of human Toll-like receptor 6
Takuya Miyakawa, Ayane Kumazawa, Yoko Fuke, Toshiro Noshita, Yumiko Miyauchi, Masahiro Okada, Masaru Tanokura   +6 more
openaire   +2 more sources

Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2–Toll-like receptor 6 pathway

Journal of Allergy and Clinical Immunology, 2010
Staphylococcus aureus heavily colonizes the lesions of patients with atopic dermatitis (AD) and is known to trigger a worsening of AD. However, the exact mechanism by which S. aureus promotes AD is unknown. Thymic stromal lymphopoietin (TSLP), which is highly expressed by keratinocytes in skin lesions of patients with AD and bronchial epithelial cells ...
Anh Tuan, Vu, Tadashi, Baba, Xue, Chen, Tuan Anh, Le, Hirokazu, Kinoshita, Yang, Xie, Seiji, Kamijo, Keiichi, Hiramatsu, Shigaku, Ikeda, Hideoki, Ogawa, Ko, Okumura, Toshiro, Takai   +11 more
openaire   +2 more sources

Estimation of systemic and mucosal toll-like receptors 4 and 6 in women with breast tumor

Journal of Medical Society, 2023
ABSTRACT Background: Toll-like receptors (TLRs) have generated an extraordinary amount of interest in cancer research in the last decade. More recently, TLR-mediated signaling pathways have been shown to support tumor cell growth in vitro and in vivo.
Thamer Shather Shaheed, Wala Noori Majeed Barem, Frial Gemeel Abd, Falah Hasan Obayes Al-Khikani   +3 more
openaire   +1 more source

Association of Toll-Like Receptor 6 (TLR6) Polymorphism Pro249Ser with Asthma Phenotypes

Journal of Allergy and Clinical Immunology, 2011
M O N D A Y 635 Association of Toll-Like Receptor 6 (TLR6) Polymorphism Pro249Ser with Asthma Phenotypes B. Aubin, J. Meng, C. Barnes, B. E. May, L. J. Rosenwasser; Children’s Mercy Hospital, Kansas City, MO, Children’s Mercy Hospital/ UMKC SOM, Kansas City, MO.
B. Aubin, J. Meng, C. Barnes, B.E. May, L.J. Rosenwasser   +4 more
openaire   +1 more source