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Expression of Toll-like receptors 2, 4 and 6 in different cell populations of the equine endometrium
Veterinary Immunology and Immunopathology, 2017Subfertility in mares is mainly caused by endometrial diseases. Alterations of Toll-like receptors (TLRs) are associated with endometrial disorders in women. This study investigated TLRs 2, 4 and 6 in the equine endometrium. Endometria of 21 mares were examined by histology, PCR and immunohistochemistry. Tissues from 2 mares were considered normal. The
Sandra, Schöniger +2 more
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Multiple Toll-like receptor ligands induce an IL-6 transcriptional response in skeletal myocytes
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2006Toll-like receptors (TLRs) comprise a critical sentinel that monitors body compartments for the presence of pathogens. Skeletal muscle expresses TLRs and responds to pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS), by mounting an innate immune response.
Robert A, Frost +2 more
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Immunopharmacology and Immunotoxicology, 2007
Our previous study demonstrated that interleukin (IL)-6 is protective against hemorrhagic lung inflammation induced by lipopolysaccharide (LPS) in mice, at least partly, by inhibition of the enhanced expressions of proinflammatory cytokines. The present study elucidated the role of IL-6 in Toll like receptor (TLR) 4 and 2 expressions in the lung during
Ken-Ichiro, Inoue +8 more
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Our previous study demonstrated that interleukin (IL)-6 is protective against hemorrhagic lung inflammation induced by lipopolysaccharide (LPS) in mice, at least partly, by inhibition of the enhanced expressions of proinflammatory cytokines. The present study elucidated the role of IL-6 in Toll like receptor (TLR) 4 and 2 expressions in the lung during
Ken-Ichiro, Inoue +8 more
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Toll-like receptor (TLR)6 and TLR1 differentiation in gene expression studies of Johne's disease
Veterinary Immunology and Immunopathology, 2010Johne's disease (JD) is a mycobacterial infection of the gut affecting ruminants and other species caused by Mycobacterium avium subspecies paratuberculosis (MAP). The role of toll-like receptors (TLR) in the pathogenesis of JD has been previously identified at the level of gene expression.
Karren M, Plain +4 more
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Pediatric Infectious Disease Journal, 2014
Klebsiella pneumoniae is a common cause of nosocomial pneumonia, especially in children. Toll-like receptors plays an important role in defense against this pathogen. The impact of human TLR6 polymorphisms on susceptibility to K. pneumoniae infection is poorly understood.
Haiou, Yang +4 more
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Klebsiella pneumoniae is a common cause of nosocomial pneumonia, especially in children. Toll-like receptors plays an important role in defense against this pathogen. The impact of human TLR6 polymorphisms on susceptibility to K. pneumoniae infection is poorly understood.
Haiou, Yang +4 more
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Inflammatory Bowel Diseases, 2006
Evidence that a deficient innate immune response toward the bacterial flora of the gut plays a role in the pathogenesis of inflammatory bowel disease (IBD) is growing. This is underscored by the finding of the association between CARD15 variants and Crohn's disease (CD) and D299G in Toll-like receptor (TLR) 4 and IBD.
Pierik, M. +6 more
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Evidence that a deficient innate immune response toward the bacterial flora of the gut plays a role in the pathogenesis of inflammatory bowel disease (IBD) is growing. This is underscored by the finding of the association between CARD15 variants and Crohn's disease (CD) and D299G in Toll-like receptor (TLR) 4 and IBD.
Pierik, M. +6 more
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Cancer Chemotherapy and Pharmacology, 2018
Despite significant advances in our ability to treat cancer, cytotoxic chemotherapy continues to be the mainstay treatment for many solid tumours. Chemotherapy is commonly associated with a raft of largely manageable adverse events; however, gastrointestinal (GI) toxicity (also termed mucositis) remains a significant challenge with little in the way of
Khan, S., Wardill, H.R., Bowen, J.M.
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Despite significant advances in our ability to treat cancer, cytotoxic chemotherapy continues to be the mainstay treatment for many solid tumours. Chemotherapy is commonly associated with a raft of largely manageable adverse events; however, gastrointestinal (GI) toxicity (also termed mucositis) remains a significant challenge with little in the way of
Khan, S., Wardill, H.R., Bowen, J.M.
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[Expression of cytokines of interleukin-6 family in gingival fibroblasts by Toll-like receptor-2].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2014To investigate whether signaling through Toll-like receptor-2 (TLR-2) can affect the expression of some cytokines in human gingival fibroblasts.The gingival fibroblasts were isolated and cultured in vivo, divided into blank control group, lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg) group and Escherichia coli (Ec) group.
Hong, Xin, Yan-hua, Wang, Hao, Liu
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Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids
Nutrients, 2018Philip Calder, Marcelo Macedo Rogero
exaly