TOLL-LIKE RECEPTORS IN CHRONIC LYMPHOCYTIC LEUKEMIA
Mediterranean Journal of Hematology and Infectious Diseases, 2012 -
Marta Muzio +2 more
doaj +3 more sources
Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization
Advanced Healthcare Materials, EarlyView.A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng
Molood Behbahanipour +11 more
wiley +1 more source
Candida and Toll-Like Receptors
Gynecology Obstetrics & Reproductive Medicine, 2012 Candida is a dimorphic fungus living as a commensal organism in human vagina. However it can cause infection under some conditions. Some factors, such as stratification of vaginal epithelial cells, natural flora and acidic pH, prevent infection by this ...
Şayeste Demirezen +2 more
doaj
Selective constraint acting on TLR2 and TLR4 genes of Japanese Rana frogs [PDF]
PeerJ, 2018 Toll-like receptors (TLRs) are an important component of innate immunity, the first line of pathogen defence. One of the major roles of TLRs includes recognition of pathogen-associated molecular patterns.
Quintin Lau +3 more
doaj +2 more sources
Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]
, 2016 Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui +2 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen +9 more
wiley +1 more source
NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [PDF]
, 2006 Activation of mammalian innate and acquired immune responses must be tightly regulated by elaborate mechanisms to control their onset and termination. MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the ...
Baltimore, David +3 more
core
Chicken Toll-like Receptor 3 Recognizes Its Cognate Ligand When Ectopically Expressed in Human Cells [PDF]
, 2007 Recognition of pathogens by toll-like receptors (TLRs) causes activation of signaling cascades that trigger cytokine secretion and, ultimately, innate immunity.
Bauer, Stefan +7 more
core +1 more source
Toll‐Like Receptor 4 Mediated Oxidized Low‐Density Lipoprotein‐Induced Foam Cell Formation in Vascular Smooth Muscle Cells via Src and Sirt1/3 Pathway [PDF]
, 2021 Zhongli Chen +10 more
openalex +1 more source
Toll-like receptors activation, signaling, and targeting: an overview
, 2019 BackgroundToll-like receptors (TLRs) are an important family of receptors that constitute the first line of defense system against microbes. They can recognize both invading pathogens and endogenous danger molecules released from dying cells and damaged ...
S. El-Zayat, H. Sibaii, F. A. Mannaa
semanticscholar +1 more source