Results 121 to 130 of about 310,367 (307)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells [PDF]

, 2000
Emmanuelle Faure, Ozlem Equils, Peter A. Sieling, Lisa Thomas, Xiao Hui Zhang, Carsten J. Kirschning, Nadia Polentarutti, Marta Muzio, Moshe Arditi   +8 more
openalex   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Enhancing the Mechanical Properties of Inherently Brittle, Biobased and Biodegradable Polyhydroxybutyrate (PHB) Polymer by Cotton Fibre Reinforcement and Interfacial Grafting

Advanced Sustainable Systems, EarlyView.
This study enhances biobassed, biodegradable polyhydroxybutyrate (PHB)s strength and ductility by reinforcing it with polyvinyl alcohol (PVA)‐coated cotton fibres and further improving interfacial bonding through maleic anhydride (MA) grafting. In addition to mechanical performance, the approaches significantly improve the gas barrier properties of the
Yilin He, Vinod Kumar Kannaujiya, Linguangze Zhuo, Wilson Ling, Chun H. Wang, Cyrille Boyer, Jin Zhang   +6 more
wiley   +1 more source

Autoinmunidad y receptores tipo Toll = Autoimmunity and toll-like receptors

Iatreia, 2012
La respuesta inmune innata está conformada por un conjunto de mecanismos que permiten reconocer los componentes propios del organismo y diferenciarlos de los microorganismos invasores para generar una primera línea de defensa.
Ossa Giraldo, Ana Claudia, Úsuga Perilla, Xiomara   +1 more
doaj  

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

Advanced Therapeutics, EarlyView.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam, Lu Yanjun, Bee Luan Khoo, Tongxu Si, Heng Zou, Mengsu Yang   +5 more
wiley   +1 more source

Toll-Like Receptor 4, But Not Toll-Like Receptor 2, Is a Signaling Receptor forEscherichiaandSalmonellaLipopolysaccharides [PDF]

, 2000
Richard I. Tapping, Sachiko Akashi, Kensuke Miyake, Paul J. Godowski, Peter S. Tobias   +4 more
openalex   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

The Lipopolysaccharide-activated Toll-like Receptor (TLR)-4 Induces Synthesis of the Closely Related Receptor TLR-2 in Adipocytes [PDF]

, 2000
Ying Lin, Hyangkyu Lee, Anders H. Berg, Michael P. Lisanti, Lawrence Shapiro, Philipp E. Scherer   +5 more
openalex   +1 more source

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source