Results 101 to 110 of about 1,069,702 (278)

General anaesthetics induce tonic inhibition and modulate the gain of neural populations : a modeling study [PDF]

, 2012
International audienceAnaesthetic agents are known to affect extra-synaptic GABAergic receptors[1], which induce tonic inhibitory currents. Since these receptors are very sensitive to small concentrations of agents, they are supposed to play an important
Hutt Axel, Thomas Voegtlin, Voegtlin Thomas, Axel Hutt, Voegtlin, Thomas, Hutt, Axel   +5 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Inverse Design of Nanoparticulate Materials

Advanced Materials, EarlyView.
Inverse design shifts nanomaterial development from empirical trial‐and‐error to predictive model‐driven strategies. It can rely on knowledge‐based, data‐based, or hybrid process and property functions. This perspective article provides a practical framework for applying inverse design based on instructive examples. It discusses which modeling approach
Nabi Etienne Traoré, Annika Mauch, Michelle Berthold, Lukas Pflug, Wolfgang Peukert, Nicolas Vogel   +5 more
wiley   +1 more source

Linking Polyelectrolyte Modification and Enzyme‐Catalyzed Phenolic Acid Functionalization of Cellulose Fiber for Functional Foams

Advanced Materials Technologies, EarlyView.
Cellulose fibers functionalized using cationic poly(Dimethyldiallylammonium chloride) (polyDADMAC) and laccase‐mediated ferulic acid system are processed into foams using different surfactants (Anionic, cationic, and non‐ionic). Fiber–surfactant interactions influence foam stabilization and porous structure formation during convective drying, producing
Abirami Senthil, Sara Wallstén, Paul Christakopoulos, Ulrika Rova, Io Antonopoulou   +4 more
wiley   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Propofol-induced GABAergic Tonic Inhibition Diminishes α-rhythms and Induces δ-rhythms in neuronal populations [PDF]

, 2013
Anaesthetic agents such as propofol are known to have an effect on both synaptic and extra-synaptic receptors. On the one hand, binding of propofol to GABA A synaptic receptors induces a phasic inhibition, as opposed to tonic inhibition which seems ...
Buhry, Laure, Hutt, Axel
core   +3 more sources

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Protein kinase C regulates tonic GABAA receptor-mediated inhibition in the hippocampus and thalamus. [PDF]

, 2013
Tonic inhibition mediated by extrasynaptic GABAA receptors (GABAA Rs) is an important regulator of neuronal excitability. Phosphorylation by protein kinase C (PKC) provides a key mode of regulation for synaptic GABAA Rs underlying phasic inhibition ...
Smart, TG, Bright, DP
core  

GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity

, 2010
: GABA is synthesized from glutamate by glutamate decarboxylase (GAD), which exists in two isoforms, that is, GAD65 and GAD67. In line with GAD65 being located in the GABAergic synapse, several studies have demonstrated that this isoform is important ...
Nilsen, Linn Hege, Vestergaard, Henrik T, Elvar M. Eyjolfsson, Arne Schousboe, Helle S. Waagepetersen, Linn Hege Nilsen, Walls, Anne B, Schousboe, Arne, Eyjolfsson, Elvar M, Waagepetersen, Helle S, Anne B. Walls, Ursula Sonnewald, Suzanne L. Hansen, Hansen, Suzanne L, Sonnewald, Ursula, Henrik T. Vestergaard   +15 more
core   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source