Results 111 to 120 of about 1,069,702 (278)

The Functional Role of Spontaneously Opening GABAA Receptors in Neural Transmission

Frontiers in Molecular Neuroscience, 2019
Ionotropic type of γ-aminobutyric acid receptors (GABAARs) produce two forms of inhibitory signaling: phasic inhibition generated by rapid efflux of neurotransmitter GABA into the synaptic cleft with subsequent binding to GABAARs, and tonic inhibition ...
Nathanael O’Neill, Sergiy Sylantyev
doaj   +1 more source

Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?

, 2008
GABA(A) receptors (GABA(A)Rs) assembled of different subunits mediate tonic and phasic inhibition in hippocampal neurons. CA1/CA3 pyramidal cells (PCs) predominantly express alpha5 subunits whereas dentate gyrus granule cells (DGGCs) and molecular layer (
Glykys, J, Mann, Edward, Mody, I
core   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

NMDA receptor mediated tonic excitatory currents are elicited by EAAT inhibition on human neocortical pyramidal neurons

Frontiers in Synaptic Neuroscience
IntroductionAmbient glutamate is capable of regulating neural excitability and contributes to several brain pathologies. It is well established by experiments on rodent tissue that extrasynaptic glutamate –mainly regulated by astrocytic glutamate uptake-
Béla Márton, Béla Márton, Levente Ecsedi, Krisztina Pocsai, Abdennour Douida, Karri Lamsa, Gábor Hutóczki, Álmos Klekner, Balázs Pál   +8 more
doaj   +1 more source

Glycine and GABAA receptors mediate tonic and phasic inhibitory processes that contribute to prepulse inhibition in the goldfish startle network

Frontiers in Neural Circuits, 2015
Prepulse inhibition (PPI) is understood as an inhibitory process that attenuates sensory flow during early stages (20-1000ms) of information processing. Here, we applied in vivo electrophysiology and pharmacology to determine if prepulse inhibition (PPI)
Paul C.P. Curtin, Thomas ePreuss
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Thalamic distribution and effects of 5-HT2C receptors on tonic GABAA inhibition and absence seizures: implications for treatment

Frontiers in Pharmacology
IntroductionChildhood absence epilepsy (CAE) is associated with abnormal thalamocortical oscillations and enhanced GABAergic function in the ventrobasal (VB) thalamus, including increased extrasynaptic GABAA receptor–mediated tonic currents in ...
Anna Cavaccini, Anna Cavaccini, Marcello Venzi, Cristiano Bombardi, Vincenzo Crunelli, Vincenzo Crunelli, Giuseppe Di Giovanni, Giuseppe Di Giovanni, Giuseppe Di Giovanni   +8 more
doaj   +1 more source

Tonically Active α5GABAA Receptors Reduce Motoneuron Excitability and Decrease the Monosynaptic Reflex

Frontiers in Cellular Neuroscience, 2017
Motoneurons, the final common path of the Central Nervous System (CNS), are under a complex control of its excitability in order to precisely translate the interneuronal pattern of activity into skeletal muscle contraction and relaxation. To fulfill this
Martha Canto-Bustos, Emanuel Loeza-Alcocer, Carlos A. Cuellar, Paulina Osuna, David Elias-Viñas, Vinicio Granados-Soto, Elías Manjarrez, Ricardo Felix, Rodolfo Delgado-Lezama   +8 more
doaj   +1 more source

Ambient GABA-Activated Tonic Inhibition Sharpens Auditory Coincidence Detection via a Depolarizing Shunting Mechanism

, 2011
Tonic inhibition mediated by extrasynaptic GABAAreceptors (GABAARs) has emerged as a novel form of neural inhibition in the CNS. However, little is known about its presence and function in the auditory system. Using whole-cell recordings in brain slices,
Wei Shi, Zheng-Quan Tang, Yong Lu, Emilie Hoang Dinh   +3 more
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source