Results 121 to 130 of about 57,250 (276)

Tonically Active α5GABAA Receptors Reduce Motoneuron Excitability and Decrease the Monosynaptic Reflex

Frontiers in Cellular Neuroscience, 2017
Motoneurons, the final common path of the Central Nervous System (CNS), are under a complex control of its excitability in order to precisely translate the interneuronal pattern of activity into skeletal muscle contraction and relaxation. To fulfill this
Martha Canto-Bustos, Emanuel Loeza-Alcocer, Carlos A. Cuellar, Paulina Osuna, David Elias-Viñas, Vinicio Granados-Soto, Elías Manjarrez, Ricardo Felix, Rodolfo Delgado-Lezama   +8 more
doaj   +1 more source

Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants [PDF]

, 2014
Within the nucleus accumbens (NAc), synaptic GABAA receptors (GABAARs) mediate phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to cocaine.
Dixon, Claire I., Sarah King (4460617), Herd, Murray B., Swinny, Jerome, Lambert, Jeremy J., King, Sarah L., Claire Dixon (4461196), M B Herd (16180043), E P Maguire (16180034), Macpherson, Tom, Maguire, Edward P., J J Lambert (16056899), D Belelli (16056896), D N Stephens (16042424), J D Swinny (16180040), Swinny, Jerome D., Stephens, David N., T MacPherson (16180037), Belelli, Delia   +18 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Heteromeric α/β glycine receptors regulate excitability in parvalbumin-expressing dorsal horn neurons through phasic and tonic glycinergic inhibition [PDF]

, 2017
The dorsal horn (DH) of the spinal cord is an important site for modality specific processing of sensory information and is essential for contextually relevant sensory experience.
B. A. Graham, K. A. Boyle, D. I. Hughes, Graham, B.A., R. J. Callister, Callister, R.J., Boyle, K.A., Gradwell, M.A., Hughes, D.I., M. A. Gradwell   +9 more
core   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Functional hallmarks of GABAergic synapse maturation and the diverse roles of neurotrophins

Frontiers in Cellular Neuroscience, 2011
Functional impairment of the adult brain can result from deficits in the ontogeny of GABAergic synaptic transmission. Gene defects underlying autism spectrum disorders, Rett’s syndrome or some forms of epilepsy, but also a diverse set of syndromes ...
Rosemarie eGrantyn, Rosemarie eGrantyn, Christian eHenneberger, Christian eHenneberger, Rene eJüttner, Rene eJüttner, Jochen C. Meier, Jochen C. Meier, Sergei eKirischuk, Sergei eKirischuk   +9 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Persistence of primitive reflexes associated with asymmetries in fixation and ocular motility values

Journal of Eye Movement Research
This cross-sectional study examined eye movement performance in patients aged 4 to 16 years. Measurements of eye movements were obtained before and after performing therapy for inhibition of four primitive reflexes, asymmetric tonic neck reflex ...
Vicente A. Domingo-Sanz
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Propofol-induced GABAergic Tonic Inhibition Diminishes α-rhythms and Induces δ-rhythms in neuronal populations [PDF]

, 2012
Anaesthetic agents such as propofol are known to have an effect on both synaptic and extra-synaptic receptors. On the one hand, binding of propofol to GABA A synaptic receptors induces a phasic inhibition, as opposed to tonic inhibition which seems ...
Buhry, Laure, Hutt, Axel
core   +3 more sources