Results 21 to 30 of about 2,288,208 (167)
Nature Communications, 2018 Topologically associating domain (TAD) boundaries in flies seem to be different from those in mammals. Here, the authors use Hi-C with sub-kb resolution to identify about 4000 TADs in flies, most demarcated by the insulator complexes BEAF-32/CP190 or ...
Qi Wang +3 more
doaj +1 more source
Mysteries of gene regulation: Promoters are not the sole triggers of gene expression
Computational and Structural Biotechnology Journal, 2022 Cis-regulatory elements of promoters are essential for gene regulation by transcription factors (TFs). However, the regulatory roles of nonpromoter regions, TFs, and epigenetic marks remain poorly understood in plants. In this study, we characterized the
Chi-Nga Chow +5 more
doaj +1 more source
Are Genetic Effects on Gene Expression Correlated Within TAD Boundaries?
, 2021 The purpose of this study is to understand the role of topologically associating domains(TADs) in the genetics of gene expression. A TAD is a genomic region within which DNA regulatory regions physically interact with each other more frequently than ...
Daines, Alexander
core +1 more source
Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication [PDF]
, 2019 The temporal order of DNA replication (replication timing [RT]) is highly coupled with genome architecture, but cis-elements regulating either remain elusive.
Holcomb, Nicolas P +20 more
core +1 more source
BMC Genomics, 2019 Background The three-dimensional (3D) structure of chromatins plays significant roles during cell differentiation and development. Hi-C and other 3C-based technologies allow us to look deep into the chromatin architectures.
Wei Gan +5 more
doaj +1 more source
TADs: Dynamic structures to create stable regulatory functions
, 2023 International audienceMammalian chromosomes are organized at different length scales within the cell nucleus. Topologically Associating Domains (TADs) are structural units of 3D genome organization with functions in gene regulation, DNA replication ...
da Costa-Nunes, José, A +1 more
core +1 more source
Genomics, Proteomics & Bioinformatics, 2022 Recent studies have characterized the genomic structures of many eukaryotic cells, often focusing on their relation to gene expression. However, these studies have largely investigated cells grown in 2D cultures, although the transcriptomes of 3D ...
Xin Liu +7 more
doaj +1 more source
, 2023 Transcription-factor binding to cis-regulatory regions regulates the gene expression program of a cell, but occupancy is often a poor predictor of the gene response.
Arnaud Droit (36418) +10 more
core +1 more source
, 2023 Transcription-factor binding to cis-regulatory regions regulates the gene expression program of a cell, but occupancy is often a poor predictor of the gene response.
Arnaud Droit (36418) +10 more
core +1 more source
, 2023 Transcription-factor binding to cis-regulatory regions regulates the gene expression program of a cell, but occupancy is often a poor predictor of the gene response.
Arnaud Droit (36418) +10 more
core +1 more source