Results 71 to 80 of about 2,288,208 (167)

Structural Variation Sequencing of 26 Amniotic Fluid Samples With Partial Gene Duplications and Postnatal Follow‐Up of the Fetuses

Prenatal Diagnosis, Volume 46, Issue 11, Page 1732-1745, October 2026.
ABSTRACT Objectives Partial gene duplications (PGDups) are a significant contributor to genetic disease. The precise genomic location and structure of PGDups are often unresolved using conventional methods, so prenatal diagnosis for PGDups is challenging, especially without ultrasound abnormalities.
Shengfang Qin, Xueyan Wang, Mengjia Yan, Yuxia He, Zhuo Zhang, Yan Yin, Jin Wang, Beibei Guo, Jing Wang, Na Xi, Zhaokai Li   +10 more
wiley   +1 more source

Position Effect Variegation of Penicillium rubens Genome and Application in Heterologous Production of the Plant‐Derived Anthraquinone Physcion

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
This study constructed a PiggyBac transposon mediated mutagenesis system which was used to investigate the genomic position effect on heterologous production of physcion in Penicillium ruben. This PB platform enables efficient genetic engineering for secondary metabolite production. ABSTRACT The filamentous fungus Penicillium rubens is well known as an
Meng Wu, Yushi Fu, Linqin Tang, Yongpeng Yao, Yuanyuan Pan, Gang Liu   +5 more
wiley   +1 more source

Deep Learning Predicts Hematopoietic Stem Cell Aging From 3D Chromatin Images

Aging Cell, Volume 25, Issue 10, October 2026.
Deep learning identifies age‐associated chromatin architecture signatures in 3D images of hematopoietic stem cell nuclei, providing an interpretable imaging biomarker that distinguishes young from aged cells and detects chromatin rejuvenation after treatment.
Pablo Iáñez Picazo, Eva Mejía‐Ramírez, Dario Di Bari, Elena Vitali, Maria Carolina Florian, Paula Petrone   +5 more
wiley   +1 more source

Comparison of computational methods for the identification of topologically associating domains [PDF]

, 2018
Background Chromatin folding gives rise to structural elements among which are clusters of densely interacting DNA regions termed topologically associating domains (TADs).
Giovanni Ciriello, Elisa Oricchio, Tavernari, D., Zufferey, M., Oricchio, Elisa, Tavernari, Daniele, Ciriello, G., Zufferey, Marie, Ciriello, Giovanni, Marie Zufferey, Oricchio, E., Daniele Tavernari, Tavernari D, Oricchio E, Zufferey M, Ciriello G   +15 more
core   +2 more sources

TAD conservation in vertebrate genomes is driven by stabilising selection

BMC Biology
Background Topologically associating domains (TADs) are fundamental structural and gene regulatory components of chromatin defined by regions of high intra-domain contact frequency.
Fabiana Patalano, Simen Rød Sandve, Rein Aasland, Jonas Paulsen   +3 more
doaj   +1 more source

X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation [PDF]

, 2019
Mechanisms establishing higher-order chromosome structures and their roles in gene regulation are elusive. We analyzed chromosome architecture during nematode X chromosome dosage compensation, which represses transcription via a dosage-compensation ...
Kenyon, Cynthia, Frankino, Phillip A, Bian, Qian, Podshivalova, Katie, Dillin, Andrew, Shin, Aram, Anderson, Erika C, Higuchi-Sanabria, Ryo, Meyer, Barbara J, Yang, Qiming   +9 more
core   +1 more source

Regulatory roles of three-dimensional structures of chromatin domains

Genome Biology
Background Transcriptional enhancers usually, but not always, regulate genes within the same topologically associating domain (TAD). We hypothesize that this incomplete insulation is partially due to three-dimensional structures of corresponding ...
Kelly Yichen Li, Qin Cao, Savio Ho-Chit Chow, Chiara Nicoletti, Pier Lorenzo Puri, Huating Wang, Danny Leung, Kevin Y. Yip   +7 more
doaj   +1 more source

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells [PDF]

, 2019
Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Grinstein, Jonathan D, Chi, Neil C, Amaral, Maria Luisa, Zhu, Quan, Wu, Jun, Evans, Sylvia M., Huang, Hui, Li, Ting, Ma, Kaiyue, Farah, Elie N, Grinstein, Jonathan D., Izpisua-Belmonte, Juan-Carlos, Chi, Neil C., Izpisua Belmonte, Juan Carlos, Preissl, Sebastian, Ren, Bing, Huang, Hui-Tzu, Evans, Sylvia M, Destici, Eugin, Yu, Leqian, Zhang, Yanxiao, Lee, Ah Young, Chee, Sora, Ye, Zhen, Farah, Elie N., Qiu, Yunjiang, Fang, Rongxin, Hu, Rong, Sylvia M. Evans, Elie N. Farah, Hui Huang, Yanxiao Zhang, Ting Li, Quan Zhu, Jun Wu, Kaiyue Ma, Neil C. Chi, Jonathan D. Grinstein, Leqian Yu, Juan Carlos Izpisua Belmonte, Sebastian Preissl, Maria Luisa Amaral, Rong Hu, Yunjiang Qiu, Eugin Destici, Bing Ren, Zhen Ye, Ah Young Lee, Rongxin Fang, Sora Chee   +49 more
core   +1 more source

Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging

, 2023
Little is known about three-dimensional (3D) genome organization in skeletal muscle stem cells [also called satellite cells (SCs)]. Here, we comprehensively map the 3D genome topology reorganization during mouse SC lineage progression.
Zhou, Qin, Zhao, Yu, Li, Yuying, Wu, Zhenguo, Ding, Yingzhe, Chen, Xiaona, He, Liangqiang, ALFONSI, Maria Vittoria, Sun, Hao, Wang, Huating   +9 more
core   +1 more source

CTCF modulates allele-specific sub-TAD organization and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains

Genome Biology, 2019
Background Genomic imprinting is essential for mammalian development and provides a unique paradigm to explore intra-cellular differences in chromatin configuration.
David Llères, Benoît Moindrot, Rakesh Pathak, Vincent Piras, Mélody Matelot, Benoît Pignard, Alice Marchand, Mallory Poncelet, Aurélien Perrin, Virgile Tellier, Robert Feil, Daan Noordermeer   +11 more
doaj   +1 more source