Results 81 to 90 of about 2,288,208 (167)

Birth and upgrowth of the Hox topological domains during evolution

, 2016
The recently discovered chromatin compartments called topologically associating domains (TADs) are essential for the three-dimensional organization of regulatory interactions driving gene expression.
Jacqueline Deschamps, Deschamps, J., Hubrecht Institute with UMC   +2 more
core   +1 more source

TADKB: Family classification and a knowledge base of topologically associating domains [PDF]

, 2019
Background Topologically associating domains (TADs) are considered the structural and functional units of the genome. However, there is a lack of an integrated resource for TADs in the literature where researchers can obtain family classifications and ...
Zheng Wang, Wang, Nan, Liu, Tong, Wang, Zheng, Tong Liu, Jacob Porter, Hao Zhu, Zhu, Hao, Nan Wang, Zheng Sun, Yin-Yuan Mo, Porter, Jacob, Zhao, Chenguang, Chenguang Zhao, Sun, Zheng, Mo, Yin-Yuan   +15 more
core   +1 more source

Cross-platform Hi-C meta-analysis identifies functional insulators that actively block enhancer-promoter interactions

Nature Communications
The function of topologically associating domain (TAD) boundaries as transcriptional insulators remains a fundamental controversy in genome biology. Here, we demonstrate that bona fide Functional Insulators (FINs) should be defined dynamically by their ...
Jian Cui, Wanying Xu, Xiuyuan Lang, Shanshan Zhang, Leina Lu, Xiaoxiao Liu, Yan Li, Fulai Jin   +7 more
doaj   +1 more source

Ligand-dependent enhancer activation indirectly modulates non-target promoters in a chromatin domain

eLife
Transcription activation of genes by estrogen is driven by enhancers, which are often located within the same topologically associating domain (TAD) as non-targeted promoters.
Darshika Bohra, Zubairul Islam, Sundarraj Nidharshan, Aprotim Mazumder, Dimple Notani   +4 more
doaj   +1 more source

The connection between BRG1, CTCF and topoisomerases at TAD boundaries [PDF]

, 2017
The eukaryotic genome is partitioned into topologically associating domains (TADs). Despite recent advances characterizing TADs and TAD boundaries, the organization of these structures is an important dimension of genome architecture and function that is
Lian, Jane B., Imbalzano, Anthony N., Stein, Janet L., Stein, Gary S., Barutcu, Ahmet Rasim   +4 more
core   +1 more source

Regulatory variants of FOXG1 in the context of its topological domain organisation

, 2017
FOXG1 syndrome is caused by FOXG1 intragenic point mutations, or by long-range position effects (LRPE) of intergenic structural variants. However, the size of the FOXG1 regulatory landscape is uncertain, because the associated topologically associating ...
Paskulin, Giorgio, Francesco Benedicenti, Benedicenti, Francesco, Mencarelli, Maria Antonietta, Hansen, Claus, Kikue Terada Abe, Niels Tommerup, Fonseca, Ana Carolina S., Ana Carolina S. Fonseca, Speck-Martins, Carlos Eduardo, Bak, Mads, Vianna-Morgante, Angela M, Carlos Eduardo Speck-Martins, Fonseca, Ana Carolina S, Busa, Tiffany, Mana M Mehrjouy, Antonio Novelli, Mehrjouy, Mana M, Renieri, Alessandra, Missirian, Chantal, Tommerup, Niels, Nadja Ehmke, Maria Antonietta Mencarelli, Novelli, Antonio, Giorgio Paskulin, Chantal Missirian, Abe, Kikue Terada, Mads Bak, Tiffany Busa, Ehmke, Nadja, Angela M. Vianna-Morgante, Vianna-Morgante, Angela M., Alessandra Renieri, Claus Hansen   +33 more
core   +1 more source

RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions

Nature Communications
The retinoblastoma protein (RB) is a well-characterized repressor of E2F transcriptional activity that controls genes involved in cell proliferation during the G1 phase.
Hanjun Lee, Ioanna-Maria Gkotinakou, Connor G. McGrath, Badri Krishnan, Sambhavi Animesh, Isabella Salinas, Robert Morris, Moshe Sade-Feldman, Wilhelm Haas, Michael S. Lawrence, Ioannis Sanidas   +10 more
doaj   +1 more source

MrTADFinder: A network modularity based approach to identify topologically associating domains in multiple resolutions.

PLoS Computational Biology, 2017
Genome-wide proximity ligation based assays such as Hi-C have revealed that eukaryotic genomes are organized into structural units called topologically associating domains (TADs).
Koon-Kiu Yan, Shaoke Lou, Mark Gerstein
doaj   +1 more source

Cooperative insulation of regulatory domains by CTCF-dependent physical insulation and promoter competition

Nature Communications
The specificity of gene expression during development requires the insulation of regulatory domains to avoid inappropriate enhancer-gene interactions.
Thais Ealo, Victor Sanchez-Gaya, Patricia Respuela, María Muñoz-San Martín, Elva Martin-Batista, Endika Haro, Alvaro Rada-Iglesias   +6 more
doaj   +1 more source

Cooperation between a hierarchical set of recruitment sites targets the X chromosome for dosage compensation

eLife, 2017
In many organisms, it remains unclear how X chromosomes are specified for dosage compensation, since DNA sequence motifs shown to be important for dosage compensation complex (DCC) recruitment are themselves not X-specific.
Sarah Elizabeth Albritton, Anna-Lena Kranz, Lara Heermans Winterkorn, Lena Annika Street, Sevinc Ercan   +4 more
doaj   +1 more source