Results 91 to 100 of about 1,201,498 (234)

Topologically Associating Domains: An invariant framework or a dynamic scaffold? [PDF]

Nucleus, 2015
Metazoan genomes are organized into regions of topologically associating domains (TADs). TADs are demarcated by border elements, which are enriched for active genes and high occupancy architectural protein binding sites. We recently demonstrated that 3D chromatin architecture is dynamic in response to heat shock, a physiological stress that ...
Cubeñas-Potts C, Corces VG.
europepmc   +4 more sources

Nitrospinics: Nitride Materials for Spin‐Orbit and Orbital Torques From Memory to Artificial Intelligence

Advanced Functional Materials, EarlyView.
Further advances in applications can be anticipated through the development of unique and functional materials beyond conventional alloys. Nitrogen enables tailor‐made orbital textures in various transition‐metal hosts, paving the way for devices ranging from spintronics memory to artificial intelligence hardware.
Prabhat Kumar, Gaurav Kumar Shukla, Yoshio Miura, Shinji Isogami   +3 more
wiley   +1 more source

Unexpected Asymmetric Mn‐Sb Site Mixing and Reentrant Spin‐Glass State of MnSb2Te4

Advanced Functional Materials, EarlyView.
MnSb2Te4 is an intrinsic magnetic topological insulator. Its properties are extraordinarily sensitive to tiny defects, making structural studies essential for understanding how magnetism and topology work together. This work shows that Mn can be unevenly distributed within the crystal and how that disorder is linked to a newly reported spin‐glass state
Gustavo Chavez Ponce de Leon, Ahmad Dibajeh, Gert ten Brink, Majid Ahmadi, Suyang Sun, Wei Zhang, Bart Jan Kooi, George Palasantzas   +7 more
wiley   +1 more source

Molecular basis of CTCF binding polarity in genome folding

Nature Communications, 2020
The boundaries of topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin.
Elphège P. Nora, Laura Caccianini, Geoffrey Fudenberg, Kevin So, Vasumathi Kameswaran, Abigail Nagle, Alec Uebersohn, Bassam Hajj, Agnès Le Saux, Antoine Coulon, Leonid A. Mirny, Katherine S. Pollard, Maxime Dahan, Benoit G. Bruneau   +13 more
doaj   +1 more source

Making sense of the linear genome, gene function and TADs

Epigenetics & Chromatin, 2022
Background Topologically associating domains (TADs) are thought to act as functional units in the genome. TADs co-localise genes and their regulatory elements as well as forming the unit of genome switching between active and inactive compartments.
Helen S. Long, Simon Greenaway, George Powell, Ann-Marie Mallon, Cecilia M. Lindgren, Michelle M. Simon   +5 more
doaj   +1 more source

Birth and upgrowth of the Hox topological domains during evolution

, 2016
The recently discovered chromatin compartments called topologically associating domains (TADs) are essential for the three-dimensional organization of regulatory interactions driving gene expression.
Jacqueline Deschamps, Deschamps, J., Hubrecht Institute with UMC   +2 more
core   +1 more source

GeS as an Emerging OTS Material: Atomic Structure and Modeling of ON/OFF Switching

Advanced Functional Materials, EarlyView.
The structural puzzle of glassy GeS, an advanced memory‐selector material, has finally been disentangled, revealing a patchwork of mixed tetrahedral and trigonal species. Under a high electric field, over‐ and under‐coordinated Ge and S defects, together with three‐membered rings, form an interconnected network associated with localized and extended ...
Andrey Tverjanovich, Jörg C. Neuefeind, Chris J. Benmore, Daniele Fontanari, Anton Sokolov, Maxim Khomenko, Shinji Kohara, Aleksei Bytchkov, Takeshi Usuki, Maria Bokova, Mohammad Kassem, Pascal Masselin, Mariana Milochova, Eugene Bychkov   +13 more
wiley   +1 more source

Tales from topographic oceans: topologically associated domains and cancer [PDF]

Endocrine-Related Cancer, 2019
The 3D organization of the genome within the cell nucleus has come into sharp focus over the last decade. This has largely arisen because of the application of genomic approaches that have revealed numerous levels of genomic and chromatin interactions, including topologically associated domains (TADs). The current review examines how these domains were
openaire   +2 more sources

Configuration‐Encoded Cell Alignment by Light‐Gated Silicon Photovoltaic Microcell Arrays

Advanced Functional Materials, EarlyView.
Light‐gated silicon photovoltaic microcells convert pulsed illumination into localized electrical cues. Arranging otherwise similar microcells into four‐lobed, six‐lobed, or circular patterns directs fibroblasts into corresponding local arrangements without wired stimulation.
Yifan Tao, Ilayda Namli, Joseph Christakiran Moses, Youdi Liu, Suihong Liu, Syed Hasan Askari Rizvi, Yasar Ozer Yilmaz, Ibrahim T. Ozbolat   +7 more
wiley   +1 more source

Large scale genomic reorganization of topological domains at the HoxD locus

Genome Biology, 2017
Background The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster.
Pierre J. Fabre, Marion Leleu, Benjamin H. Mormann, Lucille Lopez-Delisle, Daan Noordermeer, Leonardo Beccari, Denis Duboule   +6 more
doaj   +1 more source