Results 221 to 230 of about 6,238 (235)

A Review of Methods to Quantify the Genomic Similarity of Topological Associating Domains

Journal of Computational Biology, 2019
Abstract Topologically associating domains (TADs) are the most fundamental elements and significant structures of the eukaryotic genome. Currently, algorithms have been developed to find the TADs. But few algorithms are reported to compare the similarity of TADs between genomes.
Yufang Li, Aoshen Wu, Gang Liu, Lei Liu
openaire   +2 more sources

A functional variant in the boundary of a topological association domain is associated with pancreatic cancer risk

Molecular Carcinogenesis, 2019
AbstractAs the proper binding of CCCTC‐binding factor (CTCF) in the boundaries of topological association domains (TADs) was important for chromatin structures and gene regulation, we hypothesized that single nucleotide polymorphisms (SNPs) affecting CTCF binding in TAD boundaries might contribute to pancreatic cancer (PC) susceptibility.
Shufang Mei, Juntao Ke, Jianbo Tian, Pingting Ying, Nan Yang, Xiaoyang Wang, Danyi Zou, Xiating Peng, Yang Yang, Ying Zhu, Yajie Gong, Rong Zhong, Jiang Chang, Xiaoping Miao   +13 more
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TADBay: A Bayesian Construction of Topologically Associated Domains

2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2022
Carlos Soto 0002, Darshan W. Bryner, Audrey Dalgarno, Nicola Neretti, Anuj Srivastava   +4 more
openaire   +1 more source

Self-organization of a chromatin fibril into topologically-associated domains

Russian Journal of Bioorganic Chemistry, 2017
A number of recent experimental approaches demonstrated that a three-dimensional organization of the eukaryotic genome play an important role in the regulation of its activity. One of the most important results was a discovery of the genome separation into relatively independent topologically-associated domains (TADs).
S. V. Razin, A. A. Gavrilov, P. Kos, S. V. Ulianov   +3 more
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Automatic Association of Cross-Domain Network Topology

2022 IEEE International Conference on Trust, Security and Privacy in Computing and Communications (TrustCom), 2022
Sai Han, Zelin Wang, Guangquan Wang, Qiukeng Fang, Hongbing Ma, Lin Lin, Lexi Xu, Heng Zhang   +7 more
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Topologically Associating Domains in 3D Chromatin Organization

The spatial organization of the genome within the nucleus is crucial in regulating gene expression, DNA replication, and other cellular processes. Topologically Associating Domains (TADs) is a important feature, and is the compartmentalization of the genome into discrete regulatory clusters. The review goes through biophysical and mathematical models
Murari Ambati, Abdullah Choudhary
openaire   +1 more source

CATAD: exploring topologically associating domains from an insight of core-attachment structure

Briefings in Bioinformatics, 2023
Xiaoqing Peng
exaly  

Differentially methylated topologically associating domains in brain tumors

2021
In recent years, cancer has become one of the main causes of human death all over the world. Cancer is a generation of unhealthy cells that neither grow nor operate normally. Central nervous system (CNS) tumor is a creation of abnormal cells either in the spinal cord or in the brain.
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LPAD: using network construction and label propagation to detect topologically associating domains from Hi-C data

Briefings in Bioinformatics, 2023
Sun Jialiang
exaly  

Spectral methods for the detection and characterization of Topologically Associated Domains

2019
VCU Theses and ...
openaire   +1 more source