Results 131 to 140 of about 165,830 (263)

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Serum total bile acid correlates with macrophage-related immune features in colorectal cancer patients after cholecystectomy. [PDF]

Am J Cancer Res
Kong W, Liu W, Yu L, Wang M, Jia H, Wang Z, Gao F.   +6 more
europepmc   +1 more source

Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis. [PDF]

BMC Gastroenterol, 2020
Xie X, Dong J, Lu G, Gao K, Li X, Mao W, Chen F, Tong Z, Li B, Li W.   +9 more
europepmc   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

A nomogram integrating dynamic total bile acid monitoring, medication history, and curative effect for preterm birth prediction in twin pregnancies with intrahepatic cholestasis of pregnancy. [PDF]

BMC Pregnancy Childbirth
Ding F, Li J, Zhang M, Zhao Y, Liang S, Zhang Q.   +5 more
europepmc   +1 more source

The association of serum total bile acid with non-alcoholic fatty liver disease in Chinese adults: a cross sectional study. [PDF]

Lipids Health Dis, 2020
Zhang Z, Dai W, Weng S, Luo M, Fu J, Zadroga JA, Spolitu S, Peng D.   +7 more
europepmc   +1 more source

Total faecal bile acid excretion in children. [PDF]

Archives of Disease in Childhood, 1970
openaire   +2 more sources

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Temporal profile of serum total bile acid levels and their value in the evaluation of early graft dysfunction in living donor liver transplantation: a prospective cohort study. [PDF]

Clin Transplant Res
Sundararajan VB, Kumar S, Kilambi R, Thomas S.   +3 more
europepmc   +1 more source

Serum Fibroblast Growth Factor 19 and Total Bile Acid Concentrations Are Potential Biomarkers of Hepatocellular Carcinoma in Patients with Type 2 Diabetes Mellitus. [PDF]

Biomed Res Int, 2020
Sun Y, Zhu M, Zhao H, Ni X, Chang R, Su J, Huang H, Cui S, Wang X, Yuan J, Yuan J, OuYang R, Zhang R, Chen W, Gu Y, Sun Y.   +15 more
europepmc   +1 more source