Results 101 to 110 of about 1,840,129 (319)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The First Total Synthesis of Tanzawaic Acid B

, 2023
The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the ...
Hisazumi, Tsutsui, Yutaro, Maekawa, Kiyotaka, Toyoyama, Shintaro, Hiraishi, Hiyo, Natsukawa, Atsuhiro, Takano, Masaki, Honda, Takumi, Yoshida, Teruyuki, Sato, Daiki, Hiraga, Kyohei, Suzuki, Takatsugu, Murata, Natsumi, Shibata, Yasutaka, Tasaki, Takehiko, Inohana, Yuki, Suzuki, Yuma, Umezaki, Hirokazu, Kubota, Keita, Yonekura, Keiichi, Ito, Naoki, Egashira, Isamu, Shiina, Takahiro, Mori, Satoru, Tateyama   +23 more
core   +1 more source

Concise Total Syntheses of (+)‐Brefeldin A, Diastereomers and Analogs and Their Biological Activity

ChemistryEurope, 2023
Brefeldin A is an important natural product and biochemical tool with cell‐modulating and other diverse biological activities. To explore its chemical space, a generally applicable strategy for total syntheses of naturally occurring (+)‐brefeldin A (BFA),
Dr. Mikhail K. Klychnikov, Dr. Radek Pohl, Dr. Ivana Císařová, Dr. Miroslav Hájek, Dr. Ullrich Jahn   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Studies towards the total synthesis of heteroclitin F and taiwanschirin A, B, C, and D

, 2021
This thesis initially describes model studies developed towards key structural fragments of the taiwanschirin family of natural products. Through the use of these models, an original approach was conceived to enable the installation of the (Z)–enone as a
Haughey, Maxwell Brian
core   +1 more source

Total Synthesis and Biological Profiling of Putative (±)-Marinoaziridine B and (±)-N-Methyl Marinoaziridine A

Marine Drugs
The total synthesis of two new marine natural products, (±)-marinoaziridine B 7 and (±)-N-methyl marinoaziridine A 8, was accomplished. The (±)-marinoaziridine 7 was prepared in a six-step linear sequence with a 2% overall yield.
Anđela Buljan, Višnja Stepanić, Ana Čikoš, Sanja Babić Brčić, Krunoslav Bojanić, Marin Roje   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Catalytic enantioselective desymmetrisation as a tool for the synthesis of hodgkinsine and hodgkinsine B.

, 2012
Two palladium-catalysed amination protocols are deployed in the desymmetrisation of the complex dimeric alkaloid meso-chimonanthine. The power of these transformations is showcased in an efficient formal and total synthesis of the natural products ...
RH Snell, Willis, Michael, Woodward, RL, RL Woodward, Durbin, MJ, Willis, MC, MJ Durbin, Snell, RH, MC Willis   +8 more
core   +1 more source

Total Synthesis of Sclerotioloid A

, 2023
A four-step total synthesis of a structurally unique N-propargyllated 2,5-diketopiperazine alkaloid sclerotioloid A has been achieved.
Juha, Siitonen
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source