Results 81 to 90 of about 10,668,490 (318)
Evolution of a Strategy for the Total Synthesis of the Ganoderma Meroterpenoid Ganoapplanin
ChemistryEuropeHerein, a detailed account of the efforts leading to the recently published synthesis of the Ganoderma meroterpenoid ganoapplanin, a natural product identified as an inhibitor of T‐type voltage‐gated calcium channels, is provided. Ganoapplanin, which was
Nicolas Müller +9 more
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Recent progress on the total synthesis of acetogenins from Annonaceae
Beilstein Journal of Organic Chemistry, 2008 An overview of recent progress on the total synthesis of acetogenins from Annonaceae during the past 12 years is provided. These include mono-tetrahydrofurans, adjacent bis-tetrahydrofurans, nonadjacent bis-tetrahydrofurans, tri-tetrahydrofurans ...
Nianguang Li +4 more
doaj +1 more source
The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
Molecules, 2019 Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of ...
Bo Wang +6 more
doaj +1 more source
Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis
Frontiers in Chemistry, 2022 Transition metal catalysis plays an essential role in the total synthesis of natural products. Cobalt-mediated asymmetric catalysis has successfully been used as a primary or a secondary step in the total synthesis of natural products, especially ...
Shu Xiao +6 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Marine Natural Products in Preclinical Cancer Studies: Ten Years of Advanced Total Synthesis
Marine DrugsMarine ecosystems represent an exceptional reservoir of structurally diverse metabolites with remarkable pharmacological potential. Over the past decades, the exploration of marine organisms has led to the discovery of an ever-expanding number of ...
Ester Colarusso +4 more
doaj +1 more source
First total synthesis of kipukasin A
Beilstein Journal of Organic Chemistry, 2017 In this paper, a practical approach for the total synthesis of kipukasin A is presented with 22% overall yield by using tetra-O-acetyl-β-D-ribose as starting material.
Chuang Li +4 more
doaj +1 more source
An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies
Molecules, 2019 Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and
Qili Lu +3 more
doaj +1 more source
Marine Drugs, 2021 Intracellular Ca2+ plays a pivotal role in the control of a large series of cell functions in all types of cells, from neurotransmitter release and muscle contraction to gene expression, cell proliferation and cell death.
Paula González-Andrés +5 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source