Results 71 to 80 of about 10,668,490 (318)

Progress in the total synthesis of resin glycosides

Frontiers in Chemistry, 2022
Resin glycosides, mainly distributed in plants of the family Convolvulaceae, are a class of novel and complex glycolipids. Their structural complexity and significant biological activities have received much attention from synthetic chemists, and a ...
Wenli Wang, Yuxin Li, Ye He, Xing Jiang, Ying Yi, Xihan Zhang, Shiyu Zhang, Guangtong Chen, Min Yang, Jia-Lie Luo, Boyi Fan   +10 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Atroposelective Total Synthesis of Darobactin A [PDF]

, 2022
A concise, modular synthesis of the novel antibiotic darobactin A is disclosed. The synthesis successfully forges the hallmark strained macrocyclic ring systems in a sequential fashion.
Kelly, Eberle, Debora, Chiodi, Fabian, Schneider, Solomon, Reisberg, phil, baran, Jason, Chen, masato, saito, Hugh, Nakamura, You-Chen, Lin   +8 more
core   +1 more source

Synthetic Study on Bicyclic Pyranonaphthoquinone Natural Products: Construction of the Dioxabicyclo[3.3.1]nonene Motif

ChemistryEurope
A concise method for the construction of dioxabicyclo[3.3.1]nonene framework has been developed. This structural motif has recently been identified in hybrid‐type pyranonaphthoquinone‐class natural products.
Yoshio Ando, Sota Ajima, Ken Ohmori
doaj   +1 more source

Total Syntheses of Marine Natural Products Lyngbyabellin O and Lyngbyabellin P

Marine Drugs
Lyngbyabellins O and P are complex natural products derived from non-ribosomal peptide synthetase/polyketide synthase (NRPS/PKS) biosynthetic pathways and have been isolated from marine cyanobacterial sources.
Jing Chen, Shiyu Li, Chao Xu, Tao Ye
doaj   +1 more source

Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative

Molecules, 2017
Hispidulin is a naturally occurring flavone known to have various Central nervous system (CNS) activities. Proposed synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall yields.
Liang-Chieh Chen, Kai-Cheng Hsu, Lih-Chu Chiou, Hui-Ju Tseng, Wei-Jan Huang   +4 more
doaj   +1 more source

Recent Advances on Biological Activities and Structural Modifications of Dehydroabietic Acid

Toxins, 2022
Dehydroabietic acid is a tricyclic diterpenoid resin acid isolated from rosin. Dehydroabietic acid and its derivatives showed lots of medical and agricultural bioactivities, such as anticancer, antibacterial, antiviral, antiulcer, insecticidal, and ...
Meng Hao, Jianwei Xu, Houpeng Wen, Jiawei Du, Shaoyong Zhang, Min Lv, Hui Xu   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Total Synthesis of Putative Xestocyclamine A [PDF]

, 2020
The first total synthesis of putative xestocyclamine A (-)-1 is reported, a compound taking center stage on the the pathway explaining the biosynthesis of a prominent family of polycyclic alkaloids (Baldwin-Whitehead pathway).
Alois Fürstner (8255538), Zhanchao Meng (8256235), Alois, Fürstner, Zhanchao, Meng   +3 more
core   +1 more source

The First Total Synthesis of Tanzawaic Acid B [PDF]

, 2023
The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the ...
Hisazumi, Tsutsui, Yutaro, Maekawa, Kiyotaka, Toyoyama, Shintaro, Hiraishi, Hiyo, Natsukawa, Atsuhiro, Takano, Masaki, Honda, Takumi, Yoshida, Teruyuki, Sato, Daiki, Hiraga, Kyohei, Suzuki, Takatsugu, Murata, Natsumi, Shibata, Yasutaka, Tasaki, Takehiko, Inohana, Yuki, Suzuki, Yuma, Umezaki, Hirokazu, Kubota, Keita, Yonekura, Keiichi, Ito, Naoki, Egashira, Isamu, Shiina, Takahiro, Mori, Satoru, Tateyama   +23 more
core   +2 more sources