Results 111 to 120 of about 1,840,129 (319)
Oxidative radical cyclisations for total synthesis
, 2013 Manganese(III) acetate mediated radical cyclisations provide a mild and powerful tool in the construction of complex bicyclic systems. This thesis focuses on the formation of a number of alkenyl substituted [3.3.0]-bicyclic γ-lactones utilising a ...
Ferrara, Steven
core +1 more source
A Concise Total Synthesis of (±)-Stepharine and (±)-Pronuciferine
, 2022 We herein report a concise total synthesis of (±)-stepharine and (±)-pronuciferine using readily available reagents as the starting materials. This synthesis features a three-component Catellani reaction/Au-catalyzed 6-exo-dig cyclization for the ...
Qianghui, Zhou +4 more
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Total synthesis of (-)-basiliskamide B
, 2015 The total synthesis of the polyketide antibiotic (-)-basiliskamide B is described. The convergent asymmetric synthesis relies on the use of a diastereoselective ethyl ketone aldol reaction followed by a syn selective reduction of a beta-hydroxy ketone ...
Goncalves, CDS, Dias, LC
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Total Synthesis of Putative Xestocyclamine A
, 2020 The first total synthesis of putative xestocyclamine A (-)-1 is reported, a compound taking center stage on the the pathway explaining the biosynthesis of a prominent family of polycyclic alkaloids (Baldwin-Whitehead pathway).
Alois Fürstner (8255538) +3 more
core +1 more source
Atroposelective Total Synthesis of Darobactin A
, 2022 A concise, modular synthesis of the novel antibiotic darobactin A is disclosed. The synthesis successfully forges the hallmark strained macrocyclic ring systems in a sequential fashion.
Kelly, Eberle +8 more
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Total Syntheses of Hosieines A–C
Advanced ScienceThe collective total syntheses of (±)‐hosieines A–C with a cage‐like tetracyclic framework have been realized, which includes the first syntheses of hosieines B‐C.
Jiayang Zhang +5 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Total Synthesis of Darobactin A
, 2022 The total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a convergent fashion with a longest linear sequence of 16 steps from ᴅ-Garner’s aldehyde and ʟ-serine.
Louis-Charles , Campeau +13 more
core +1 more source