Results 111 to 120 of about 12,937,378 (338)
Marine Drugs, 2015 Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 μM).
Xiaoji Wang +8 more
doaj +1 more source
Total synthesis of natural products containing benzofuran rings
, 2017 Research on natural products containing benzofuran has remarkably increased during the past few decades. Newly isolated natural products with complex structures are being studied, characterized and screened for possible biological activities.
M. Heravi +3 more
semanticscholar +1 more source
Total Synthesis of (−)-Reveromycin A [PDF]
Organic Letters, 1999 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Craig A. Hutton +5 more
openaire +6 more sources
A new fast method for ceramic foam impregnation: Application to the CCVD synthesis of carbon nanotubes [PDF]
, 2007 A new process that allows preparing, in a single step, good washcoats of catalytic materials for the catalytic chemical vapour deposition (CCVD) synthesis of carbon nanotubes (CNTs) in reticulated ceramic foams is reported. It is shown that the washcoats,
Chartier, Thierry +4 more
core +3 more sources
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source
Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
Marine Drugs, 2018 The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic ...
Baijun Ye +7 more
doaj +1 more source
Asymmetric total synthesis of alkaloid natural products without external chiral sources [PDF]
, 2018 The chirality of a starting material having a chiral sp3-carbon can be preserved under some circumstances in the reaction product even though the reaction proceeds at the chiral carbon as a reaction center through reactive intermediates.
Kim, Sanghee
core
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase
Marine Drugs, 2016 There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that
Yongjie Luo +3 more
doaj +1 more source
From Target-Oriented to Motif-Oriented: A Case Study on Nannocystin Total Synthesis
Molecules, 2020 Natural product total synthesis is in essence target-oriented in that a set of organic transformations are orchestrated into a workable process, leading ultimately to the target molecule with a predefined architecture.
Weicheng Zhang
doaj +1 more source