Results 111 to 120 of about 14,498,613 (385)
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
The Total Synthesis of (−)-Lemonomycin [PDF]
Journal of the American Chemical Society, 2003 The first total synthesis of the novel glycosylated tetrahydroisoquinoline antitumor antibiotic (-)-lemonomycin has been accomplished (15 steps from 9). The highly convergent synthesis relies on a key asymmetric dipolar cycloaddition to set the stereochemistry of the aglycone core, a Suzuki fragment coupling to connect the diazabicycle to the aryl ...
Ashley, Eric R. +2 more
openaire +6 more sources
First total synthesis of kipukasin A
Beilstein Journal of Organic Chemistry, 2017 In this paper, a practical approach for the total synthesis of kipukasin A is presented with 22% overall yield by using tetra-O-acetyl-β-D-ribose as starting material.
Chuang Li +4 more
doaj +1 more source
Total Synthesis of (+)-Madangamine D [PDF]
, 2016 Madangamines are a group of bioactive marine sponge alkaloids, embodying an unprecedented diazapentacyclic skeletal type. The enantioselective total synthesis of madangamine D has been accomplished, and represents the first total synthesis of an alkaloid
Amat Tusón, Mercedes +4 more
core +1 more source
Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products.
Chemical Reviews, 2017 The pool of abundant chiral terpene building blocks (i.e., "chiral pool terpenes") has long served as a starting point for the chemical synthesis of complex natural products, including many terpenes themselves.
Zachary G Brill +3 more
semanticscholar +1 more source
Total Synthesis of (+)-Strictifolione [PDF]
Organic Letters, 2003 [reaction: see text] The synthesis of (+)-strictifolione was achieved from 3-phenylproprionaldehyde by using enantioselective allyltitanations to control the stereogenic centers at C6, C4', and C6' and a cross-methathesis to control the configuration of the double bond at C1'-C2'.
Janine Cossy, Samir BouzBouz
openaire +5 more sources
Synthesis of the spiroketal core of integramycin
Beilstein Journal of Organic Chemistry, 2013 A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a ...
Evgeny. V. Prusov
doaj +1 more source
Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products
Molecules, 2013 Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis.
Markus Kaiser, Sara C. Stolze
doaj +1 more source
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Total Synthesis of (−)-Reveromycin A [PDF]
Organic Letters, 1999 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Craig A. Hutton +5 more
openaire +6 more sources