Results 121 to 130 of about 14,498,613 (385)

From Target-Oriented to Motif-Oriented: A Case Study on Nannocystin Total Synthesis

Molecules, 2020
Natural product total synthesis is in essence target-oriented in that a set of organic transformations are orchestrated into a workable process, leading ultimately to the target molecule with a predefined architecture.
Weicheng Zhang
doaj   +1 more source

Asymmetric total synthesis of alkaloid natural products without external chiral sources [PDF]

, 2018
The chirality of a starting material having a chiral sp3-carbon can be preserved under some circumstances in the reaction product even though the reaction proceeds at the chiral carbon as a reaction center through reactive intermediates.
Kim, Sanghee
core  

Organocatalysis in total synthesis [PDF]

, 2015
Peer ...
Herrera, Raquel P., Marqués-López, Eugenia   +1 more
core   +2 more sources

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Total synthesis of (±)-chamobtusin A [PDF]

Chemical Communications, 2011
AbstractThe key stereocenter of the diterpenoid alkaloid chamobtusin A (IV) is installed via a stereoselective intramolecular Michael addition of the secondary amine to the exocyclic cyanoalkene group of (II).
Hikaru Suzuki, Sakae Aoyagi
openaire   +6 more sources

Sordarin, an antifungal agent with a unique mode of action

Beilstein Journal of Organic Chemistry, 2008
The sordarin family of compounds, characterized by a unique tetracyclic diterpene core including a norbornene system, inhibits protein synthesis in fungi by stabilizing the ribosome/EF2 complex.
Huan Liang
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Total synthesis of natural products containing benzofuran rings

, 2017
Research on natural products containing benzofuran has remarkably increased during the past few decades. Newly isolated natural products with complex structures are being studied, characterized and screened for possible biological activities.
M. Heravi, Vahideh Zadsirjan, Hoda Hamidi, P. Amiri   +3 more
semanticscholar   +1 more source

Enantioselective Total Synthesis of (+)-Psiguadial B.

Journal of the American Chemical Society, 2016
The first enantioselective total synthesis of the cytotoxic natural product (+)-psiguadial B is reported. Key features of the synthesis include (1) the enantioselective preparation of a key cyclobutane intermediate by a tandem Wolff rearrangement ...
L. Chapman, Jordan C Beck, Linglin Wu, S. Reisman   +3 more
semanticscholar   +1 more source

Enantioselective carbenoid insertion into C(sp3)–H bonds

Beilstein Journal of Organic Chemistry, 2016
The enantioselective carbenoid insertion into C(sp3)–H bonds is an important tool for the synthesis of complex molecules due to the high control of enantioselectivity in the formation of stereogenic centers.
J. V. Santiago, A. H. L. Machado
doaj   +1 more source