Results 11 to 20 of about 3,567,305 (338)
The Total Synthesis of (−)-Scabrolide A [PDF]
Journal of the American Chemical Society, 2020 The first total synthesis of the norcembranoid diterpenoid scabrolide A is disclosed. The route begins with the synthesis of two chiral pool-derived fragments, which undergo a convergent coupling to expediently introduce all 19 carbon atoms of the natural product.
Nicholas J. Hafeman +5 more
openaire +8 more sources
Total Synthesis of Entecavir [PDF]
The Journal of Organic Chemistry, 2013 Entecavir (BMS-200475) was synthesized from 4-trimethylsilyl-3-butyn-2-one and acrolein. The key features of its preparation are: (i) a stereoselective boron-aldol reaction to afford the acyclic carbon skeleton of the methylenecylopentane moiety; (ii) its cyclization by a Cp2TiCl-catalyzed intramolecular radical addition of an epoxide to an alkyne; and
Martí Bartra +10 more
openaire +7 more sources
Total Synthesis of (+)‐Cornexistin [PDF]
Angewandte Chemie, 2020 AbstractHerein, we describe the first total synthesis of (+)‐cornexistin as well as its 8‐epi‐isomer starting from malic acid. The robust and scalable route features a Nozaki–Hiyama–Kishi reaction, an auxiliary‐controlled syn‐Evans‐aldol reaction, and a highly efficient intramolecular alkylation to form the nine‐membered carbocycle. The delicate maleic
Christian Steinborn +3 more
openaire +4 more sources
Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis
Frontiers in Chemistry, 2022 Transition metal catalysis plays an essential role in the total synthesis of natural products. Cobalt-mediated asymmetric catalysis has successfully been used as a primary or a secondary step in the total synthesis of natural products, especially ...
Shu Xiao +6 more
doaj +1 more source
Total Synthesis of (−)-Isoavenaciolide [PDF]
The Journal of Organic Chemistry, 2013 An enantioselective approach to (-)-isoavenaciolide was achieved starting from 1-undecyn-3-ol. The synthesis relied upon the preparation of a chiral 4-silyloxy-2-alkenylborane by hydroboration of a protected 2,3-allenol and subsequent stereoselective addition to 2-thiophenecarboxaldehyde.
Santos, David +5 more
openaire +3 more sources
CHIMIA, 2017 Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B.
Sarah Saint-Auret +6 more
doaj +1 more source
Enantioselective Total Synthesis of (+)-Cassiol [PDF]
, 2009 An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd-2(pmdba)(3) and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early ...
Mohr, Justin T. +2 more
core +2 more sources
Synthetic Advances in Macrosphelides: Natural Anticancer Agents
Molecules, 2014 Total synthesis of macrosphelides is summarized. Synthetic approaches contain the preparation of key fragments and the final ring-closure reaction for unique 16- or 15-membered macrolactone skeletons.
Seung-Mann Paek
doaj +1 more source
Synthetic studies toward to the first totalsynthesis of Floribundane B
Orbital: The Electronic Journal of Chemistry, 2012 Floribundane B is an iridoid recently isolated by D. I. M. de Mendonça and coworkers from the leaves and the bark of the trunk of Hymenodictyon floribundum B. L. Rob, a plant used in Angola folk medicine to treat fever.
João V. S. Silva +2 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2022 A convergent strategy for the synthesis of leustroducsins and phoslactomycins has been designed, relying on the synthesis and the coupling of three main fragments.
Anaïs Rousseau +2 more
doaj +1 more source