Results 11 to 20 of about 3,850,300 (360)
Total Synthesis of (−)-Kaitocephalin [PDF]
Organic Letters, 2005 AbstractFor Abstract see ChemInform Abstract in Full Text.
Masanori, Kawasaki +3 more
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Total Synthesis of Jiadifenolide [PDF]
Angewandte Chemie International Edition, 2014 AbstractAs a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small‐molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adventurous samarium‐mediated cyclization ...
Paterson, Ian +2 more
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Optimization of Two Steps in Scale-Up Synthesis of Nannocystin A
Marine Drugs, 2021 We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol reaction to connect C4 and C5 was unreproducible during the scaling up ...
Tingrong Zhang +5 more
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Total synthesis of palau’amine [PDF]
Nature Communications, 2015 AbstractPalau’amine has received a great deal of attention in the past two decades as an attractive synthetic target by virtue of its intriguing molecular architecture and significant immunosuppressive activity. Here we report the total synthesis of palau’amine characterized by the construction of an ABDE tetracyclic ring core including a trans-bicylo ...
Namba, Kosuke +7 more
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ESTRATÉGIAS PARA A SÍNTESE DO ÁCIDO LISÉRGICO
Química Nova, 2021 STRATEGIES FOR THE SYNTHESIS OF LYSERGIC ACID. (+)-Lysergic acid [(+)-1] is a precursor of several substances with well-established pharmacological properties, including some drugs approved and commercialized around the world. Thus, the importance of (+)-
Tamiris R. C. Silva, Cristiano Raminelli
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Total Synthesis of Pyranicin. [PDF]
ChemInform, 2004 [Reaction: see text] A stereocontrolled convergent synthesis of the annonaceous acetogenin pyranicin (1) is presented. Asymmetric Horner-Wadsworth-Emmons (HWE) reactions were used to access key intermediates. The tetrahydropyran derivative 2 was obtained via an asymmetric desymmetrization of the meso-dialdehyde 6, and the butenolide fragment was ...
Daniel, Strand, Tobias, Rein
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CHIMIA, 2017 Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B.
Sarah Saint-Auret +6 more
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Frontiers in Chemistry, 2021 Selectively activating the distal inactive C-H bond for functionalization is one of the on-going challenge in organic synthetic chemistry. In recent years, benefiting from the development of selective synthesis methods, novel methodologies not only make ...
Huang Junrong +11 more
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Total Synthesis of Aquatolide [PDF]
Organic Letters, 2015 A total synthesis of the sesquiterpene lactone aquatolide has been accomplished. The central step is an intramolecular [2 + 2]-photocycloaddition of an allene onto an α,β-unsaturated δ-lactone. Other key steps are an intramolecular Horner-Wadsworth-Emmons reaction to close the lactone and an intramolecular Mukaiyama-type aldol reaction to cyclize the ...
Saya, J.M. +5 more
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Total synthesis of himastatin [PDF]
Science, 2021 The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach
Kyan A. D’Angelo +3 more
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