Results 11 to 20 of about 12,937,378 (338)
Total Synthesis of Sordaricin [PDF]
The Journal of Organic Chemistry, 2003 An enantioconvergent total synthesis of sordaricin (3), the diterpene aglycon of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule as a single regioisomer 30.
Mander, Lewis, Thomson, Regan
openaire +9 more sources
Frontiers in Chemistry, 2021 Selectively activating the distal inactive C-H bond for functionalization is one of the on-going challenge in organic synthetic chemistry. In recent years, benefiting from the development of selective synthesis methods, novel methodologies not only make ...
Huang Junrong +11 more
doaj +1 more source
Total Synthesis of Aeruginazole A [PDF]
Organic Letters, 2011 The first total synthesis of Aeruginazole A, prepared via a convergent strategy that involved both solid-phase peptide synthesis and solution phase chemistry and that enabled conservation of the stereochemistry of the intermediates, is reported.
Bruno, Paolo +4 more
openaire +5 more sources
Total Synthesis of (+)-Isatisine A [PDF]
The Journal of Organic Chemistry, 2010 The asymmetric total synthesis of (+)-isatisine A has been accomplished commencing with a Lewis acid-catalyzed cyclization of homochiral (S)-vinylcyclopropane diester and N-tosylindole-2-carboxaldehyde to construct the tetrahydrofuran ring. A palladium-catalyzed oxidative decarboxylation was utilized to obtain the dihydrofuran required for the ...
Avedis Karadeolian, Michael A. Kerr
openaire +5 more sources
Total Synthesis of (+)‐Cornexistin [PDF]
Angewandte Chemie, 2020 AbstractHerein, we describe the first total synthesis of (+)‐cornexistin as well as its 8‐epi‐isomer starting from malic acid. The robust and scalable route features a Nozaki–Hiyama–Kishi reaction, an auxiliary‐controlled syn‐Evans‐aldol reaction, and a highly efficient intramolecular alkylation to form the nine‐membered carbocycle. The delicate maleic
Christian Steinborn +3 more
openaire +4 more sources
Total Synthesis of Polysaccharides by Automated Glycan Assembly
Journal of the American Chemical Society, 2020 Polysaccharides are the most abundant biopolymers on earth that serve various structural and modulatory functions. Pure, completely defined linear and branched polysaccharides are essential to understand carbohydrate structure and function ...
Abragam A. S. Joseph +2 more
semanticscholar +1 more source
Synthesis of the Enantiomers of Thioridazine
SynOpen, 2020 Thioridazine, a well-known antipsychotic drug, has shown promising effects on several bacterial strains (including Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus).
Simen Antonsen +7 more
doaj +1 more source
Total Synthesis of (−)-Isoavenaciolide [PDF]
The Journal of Organic Chemistry, 2013 An enantioselective approach to (-)-isoavenaciolide was achieved starting from 1-undecyn-3-ol. The synthesis relied upon the preparation of a chiral 4-silyloxy-2-alkenylborane by hydroboration of a protected 2,3-allenol and subsequent stereoselective addition to 2-thiophenecarboxaldehyde.
Santos, David +5 more
openaire +3 more sources
CHIMIA, 2017 Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B.
Sarah Saint-Auret +6 more
doaj +1 more source
Enantioselective Total Synthesis of (+)-Cassiol [PDF]
, 2009 An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd-2(pmdba)(3) and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early ...
Mohr, Justin T. +2 more
core +2 more sources