Results 21 to 30 of about 1,840,129 (319)
Tetrahedron Letters, 2022 Remdesivir, the first drug approved by the FDA to treat COVID-19, is in high demand for patients infected with the SARS-CoV-2 virus. Herein, we report a facile approach minimizing the protecting group manipulations to afford remdesivir in good overall yield.
Kumar Palli, Kishore +9 more
openaire +2 more sources
CHIMIA, 2017 Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B.
Sarah Saint-Auret +6 more
doaj +1 more source
Total synthesis of gelsemoxonine [PDF]
Pure and Applied Chemistry, 2011 The first total synthesis of gelsemoxonine has been accomplished. A divinylcyclopropane–cycloheptadiene rearrangement of the highly functionalized substrate successfully assembled the spiro-quaternary carbon center connected to the bicyclic seven-membered core structure.
Jun, Shimokawa +3 more
openaire +2 more sources
Total synthesis of lamellarins D, L, and N [PDF]
, 2006 Total synthesis of cytotoxic marine alkaloids, lamellarins D, L, and N, has been achieved by using Hinsberg-type pyrrole synthesis and palladium-catalyzedSuzuki-Miyaura coupling of the 3,4-dihydroxypyrrole bistriflate 6 as the key reactions.The total ...
Fujikawa, Naotaka +5 more
core +1 more source
First Total Synthesis of (–)-Merrillianin
, 2023 The first total synthesis of (–)-merrillianin (1), which is a natural sesquiterpene with a tri- fused structure having a cyclopentane ring and five- and seven-membered lactone parts, is demonstrated.
Teppei, Kuboki +17 more
core +1 more source
Synthetic Advances in Macrosphelides: Natural Anticancer Agents
Molecules, 2014 Total synthesis of macrosphelides is summarized. Synthetic approaches contain the preparation of key fragments and the final ring-closure reaction for unique 16- or 15-membered macrolactone skeletons.
Seung-Mann Paek
doaj +1 more source
Total Synthesis of Pagoamide A
Molecules, 2021 The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous ...
Fusong Wu +4 more
doaj +1 more source
The Essence of Total Synthesis [PDF]
ChemInform, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
K C, Nicolaou, Scott A, Snyder
openaire +2 more sources
, 2021 The synthesis and study of antibiotic natural products with unique structures and mechanisms of action represents a proven strategy to combat the public health crisis posed by antibiotic-resistant bacteria. The natural product himastatin is an antibiotic
Mohammad, Movassaghi +3 more
core +1 more source
Frontiers in Chemistry, 2020 The cross-metathesis (CM) of methallyl halides catalyzed using four different ruthenium-based complexes—Grubbs catalyst, Grubbs second-generation catalyst, Hoveyda-Grubbs second-generation catalyst, and Stewart–Grubbs catalyst—was investigated.
Suresh Mandava +5 more
doaj +1 more source