Results 21 to 30 of about 3,567,305 (338)
Total synthesis of teixobactin [PDF]
Nature Communications, 2016 AbstractTo cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development.
Kang Jin +7 more
openaire +6 more sources
Total Synthesis of Pagoamide A [PDF]
Molecules, 2021 The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous structural confirmation of pagoamide A.
Fusong Wu +4 more
openaire +4 more sources
Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids. [PDF]
, 2015 A unified strategy for enantioselective total synthesis of all stereoisomers of the 2+2 family of quadrigemine alkaloids is reported. In this approach, two enantioselective intramolecular Heck reactions are carried out at the same time on precursors ...
Canham, Stephen M +6 more
core +4 more sources
Phyllostictine A : total synthesis, structural verification and determination of substructure responsible for plant growth inhibition [PDF]
, 2018 The first total synthesis of phyllostictine A (PA) is reported, which confirms the structure of this fungal metabolite and its (6S,7R,8S)-stereochemistry.
Clarkson, Guy J. +6 more
core +1 more source
A síntese dos sesquiterpenos baquenolidas The synthesis of the bakkenolide sesquiterpenes
Química Nova, 2008 The bakkenolide group of sesquiterpenes has been a focal point of synthetic efforts amongst several research laboratories all linked to our common origins at the Chemistry Institute at the State University in São Paulo.
Timothy John Brocksom +2 more
doaj +1 more source
A Concise Total Synthesis of (--)-Maoecrystal Z [PDF]
, 2011 The first total synthesis of (--)-maoecrystal Z is described. The key steps of the synthesis include a diastereoselective Ti^(III)-mediated reductive epoxide coupling reaction and a diastereoselective Sm^(II)-mediated reductive cascade cyclization ...
Cha, Jacob Y. +2 more
core +2 more sources
Molecules, 2018 Bacteria often contain rare deoxy amino sugars which are absent in the host cells. This structural difference can be harnessed for the development of vaccines. Over the last fifteen years, remarkable progress has been made toward the development of novel
Archanamayee Behera, Suvarn S. Kulkarni
doaj +1 more source
Recent advances in the total synthesis of agelastatins [PDF]
, 2010 Agelastatins represent an important family of marine alkaloids in terms of both exceptional biological activity and intriguing chemical structure.
Dong, Guangbin
core +1 more source
Total synthesis of himastatin [PDF]
Science, 2021 The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach
Kyan A. D’Angelo +3 more
openaire +5 more sources
Total Synthesis of Kingianins A, D, and F [PDF]
, 2013 A synthesis fit for a king: The total synthesis of (±)-kingianinsA, D, and F has been achieved in ten steps. Key features include the gram-scale synthesis and partial reduction of a conjugated tetrayne to a (Z,Z,Z,Z)-tetraene, the domino 8π-6π ...
Abe +70 more
core +1 more source