Results 21 to 30 of about 16,454,265 (355)
Total synthesis of himastatin [PDF]
Science, 2021 The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach
Kyan A. D’Angelo +3 more
openaire +4 more sources
Synthetic Advances in Macrosphelides: Natural Anticancer Agents
Molecules, 2014 Total synthesis of macrosphelides is summarized. Synthetic approaches contain the preparation of key fragments and the final ring-closure reaction for unique 16- or 15-membered macrolactone skeletons.
Seung-Mann Paek
doaj +1 more source
A Concise Total Synthesis of (--)-Maoecrystal Z [PDF]
, 2011 The first total synthesis of (--)-maoecrystal Z is described. The key steps of the synthesis include a diastereoselective Ti^(III)-mediated reductive epoxide coupling reaction and a diastereoselective Sm^(II)-mediated reductive cascade cyclization ...
Cha, Jacob Y. +2 more
core +2 more sources
Enantioselective Total Synthesis of (+)-Cassiol [PDF]
, 2009 An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd-2(pmdba)(3) and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early ...
Mohr, Justin T. +2 more
core +2 more sources
Total Synthesis of Formamicin. [PDF]
ChemInform, 2004 The enantioselective total synthesis of the cytotoxic plecomacrolide natural product formamicin (1) is described. Key aspects of this synthesis include the efficient transacetalation reactions of MOM ethers 28 and 38 to form the seven-membered formyl acetals 29 and 39, a late-stage Suzuki cross-coupling reaction of the highly functionalized vinyl ...
Timothy B, Durham +4 more
openaire +2 more sources
Total Synthesis of Polysaccharides by Automated Glycan Assembly
Journal of the American Chemical Society, 2020 Polysaccharides are the most abundant biopolymers on earth that serve various structural and modulatory functions. Pure, completely defined linear and branched polysaccharides are essential to understand carbohydrate structure and function ...
Abragam A. S. Joseph +2 more
semanticscholar +1 more source
Total Synthesis and Structural Revision of the Alkaloid Incargranine B [PDF]
, 2013 Seeing double: Consideration of the biosynthetic origins of incargranineB, which was originally assigned an unprecedented indolo[1.7]naphthyridine structure, led to the proposal of a dipyrroloquinoline framework as a more biosynthetically feasible ...
Bates +8 more
core +1 more source
Total Synthesis of (±)-Paeonilide [PDF]
Organic Letters, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chenying, Wang +5 more
openaire +2 more sources
Synthesis of the Enantiomers of Thioridazine
SynOpen, 2020 Thioridazine, a well-known antipsychotic drug, has shown promising effects on several bacterial strains (including Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus).
Simen Antonsen +7 more
doaj +1 more source
Total Synthesis of (−)-Tuberostemonine [PDF]
Journal of the American Chemical Society, 2002 The first total synthesis of the complex pentacyclic Stemona alkaloid tuberostemonine was accomplished in 24 steps and in 1.4% overall yield from a hydroindole intermediate which is readily obtained in three steps from Cbz-l-tyrosine. An innovative synthetic strategy was applied that relays the single stereocenter of the amino acid precursor into nine ...
Peter, Wipf +2 more
openaire +2 more sources