Results 21 to 30 of about 12,937,378 (338)
Synthetic Advances in Macrosphelides: Natural Anticancer Agents
Molecules, 2014 Total synthesis of macrosphelides is summarized. Synthetic approaches contain the preparation of key fragments and the final ring-closure reaction for unique 16- or 15-membered macrolactone skeletons.
Seung-Mann Paek
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Synthetic studies toward to the first totalsynthesis of Floribundane B
Orbital: The Electronic Journal of Chemistry, 2012 Floribundane B is an iridoid recently isolated by D. I. M. de Mendonça and coworkers from the leaves and the bark of the trunk of Hymenodictyon floribundum B. L. Rob, a plant used in Angola folk medicine to treat fever.
João V. S. Silva +2 more
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Total Synthesis of Pagoamide A [PDF]
Molecules, 2021 The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous structural confirmation of pagoamide A.
Fusong Wu +4 more
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Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids. [PDF]
, 2015 A unified strategy for enantioselective total synthesis of all stereoisomers of the 2+2 family of quadrigemine alkaloids is reported. In this approach, two enantioselective intramolecular Heck reactions are carried out at the same time on precursors ...
Canham, Stephen M +6 more
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Total synthesis of himastatin [PDF]
Science, 2021 The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach
Kyan A. D’Angelo +3 more
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Phyllostictine A : total synthesis, structural verification and determination of substructure responsible for plant growth inhibition [PDF]
, 2018 The first total synthesis of phyllostictine A (PA) is reported, which confirms the structure of this fungal metabolite and its (6S,7R,8S)-stereochemistry.
Clarkson, Guy J. +6 more
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Beilstein Journal of Organic Chemistry, 2022 A convergent strategy for the synthesis of leustroducsins and phoslactomycins has been designed, relying on the synthesis and the coupling of three main fragments.
Anaïs Rousseau +2 more
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Total synthesis of decarboxyaltenusin [PDF]
Beilstein Journal of Organic Chemistry, 2021 The total synthesis of decarboxyaltenusin (5’-methoxy-6-methyl-[1,1’-biphenyl]-3,3’,4-triol), a toxin produced by various mold fungi, has been achieved in seven steps in a yield of 31% starting from 4-methylcatechol and 1-bromo-3,5-dimethoxybenzene, where the longest linear sequence consists of five steps.
Lucas Warmuth +5 more
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A Concise Total Synthesis of (--)-Maoecrystal Z [PDF]
, 2011 The first total synthesis of (--)-maoecrystal Z is described. The key steps of the synthesis include a diastereoselective Ti^(III)-mediated reductive epoxide coupling reaction and a diastereoselective Sm^(II)-mediated reductive cascade cyclization ...
Cha, Jacob Y. +2 more
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Molecules, 2018 Bacteria often contain rare deoxy amino sugars which are absent in the host cells. This structural difference can be harnessed for the development of vaccines. Over the last fifteen years, remarkable progress has been made toward the development of novel
Archanamayee Behera, Suvarn S. Kulkarni
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