Results 31 to 40 of about 3,567,305 (338)
A review of the total syntheses of triptolide
Beilstein Journal of Organic Chemistry, 2019 Triptolide is a complex triepoxide diterpene natural product that has attracted considerable interest in the organic chemistry and medicinal chemistry societies due to its intriguing structural features and multiple promising biological activities.
Xiang Zhang, Zaozao Xiao, Hongtao Xu
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Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery
Marine Drugs, 2019 Spirotetronates are actinomyces-derived polyketides that possess complex structures and exhibit potent and unexplored bioactivities. Due to their anticancer and antimicrobial properties, they have potential as drug hits and deserve further study.
Alexander A. Braddock +1 more
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Total synthesis of decarboxyaltenusin [PDF]
Beilstein Journal of Organic Chemistry, 2021 The total synthesis of decarboxyaltenusin (5’-methoxy-6-methyl-[1,1’-biphenyl]-3,3’,4-triol), a toxin produced by various mold fungi, has been achieved in seven steps in a yield of 31% starting from 4-methylcatechol and 1-bromo-3,5-dimethoxybenzene, where the longest linear sequence consists of five steps.
Lucas Warmuth +5 more
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Marine Drugs, 2015 Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 μM).
Xiaoji Wang +8 more
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Total Synthesis and Absolute Configuration of the Marine Norditerpenoid Xestenone
Marine Drugs, 2009 Xestenone is a marine norditerpenoid found in the northeastern Pacific sponge Xestospongia vanilla. The relative configuration of C-3 and C-7 in xestenone was determined by NOESY spectral analysis.
Hiroaki Miyaoka +3 more
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The Total Synthesis of Moenomycin A [PDF]
Journal of the American Chemical Society, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Zhu, W +4 more
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Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
Marine Drugs, 2018 The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic ...
Baijun Ye +7 more
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Total Synthesis of (−)-Himalensine A
Journal of the American Chemical Society, 2017 The first enantioselective synthesis of (-)-himalensine A has been achieved in 22 steps. The synthesis was enabled by a novel catalytic, enantioselective prototropic shift/furan Diels-Alder (IMDAF) cascade to construct the ACD tricyclic core. A reductive radical cyclization cascade was utilized to build the B ring, and end-game manipulations featuring ...
Shi, H +6 more
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Total Synthesis and Structural Revision of the Alkaloid Incargranine B [PDF]
, 2013 Seeing double: Consideration of the biosynthetic origins of incargranineB, which was originally assigned an unprecedented indolo[1.7]naphthyridine structure, led to the proposal of a dipyrroloquinoline framework as a more biosynthetically feasible ...
Bates +8 more
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A new member of the fusaricidin family – structure elucidation and synthesis of fusaricidin E
Beilstein Journal of Organic Chemistry, 2017 Two hitherto unknown fusaricidins were obtained from fermentation broths of three Paenibacillus strains. After structure elucidation based on tandem mass spectrometry and NMR spectroscopy, fusaricidin E was synthesized to confirm the structure and the ...
Marcel Reimann +5 more
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