Results 61 to 70 of about 3,567,305 (338)

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies

Molecules, 2019
Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and
Qili Lu, Dipesh S. Harmalkar, Yongseok Choi, Kyeong Lee   +3 more
doaj   +1 more source

Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone

Beilstein Journal of Organic Chemistry, 2021
Highly substituted fluorenones are readily prepared in mostly fair to good yields via metal- and additive-free TBHP-promoted cross-dehydrogenative coupling (CDC) of readily accessible N-methyl-2-(aminomethyl)biphenyls and 2-(aminomethyl)biphenyls.
Ilya A. P. Jourjine, Lukas Zeisel, Jürgen Krauß, Franz Bracher   +3 more
doaj   +1 more source

Optimization of Two Steps in Scale-Up Synthesis of Nannocystin A

Marine Drugs, 2021
We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol reaction to connect C4 and C5 was unreproducible during the scaling up ...
Tingrong Zhang, Shaojie Miao, Mingxiao Zhang, Wenjie Liu, Liang Wang, Yue Chen   +5 more
doaj   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Enantioselective Total Synthesis of (+)-Salvileucalin B [PDF]

, 2011
An enantioselective total synthesis of the diterpenoid natural product (+)-salvileucalin B is reported. Key findings include a copper-catalyzed arene cyclopropanation reaction to provide the unusual norcaradiene core and a reversible retro ...
Levin, Sergiy, Nani, Roger R., Reisman, Sarah E.   +2 more
core   +1 more source

Total Observed Organic Carbon (TOOC): A synthesis of North American observations [PDF]

, 2007
Measurements of organic carbon compounds in both the gas and particle phases measured upwind, over and downwind of North America are synthesized to examine the total observed organic carbon (TOOC) over this region.
Aiken, A. C., Allan, J. D., Apel, E., Atlas, E. L., Baker, A. K., Bates, T. S., Beyersdorf, A. J., Blake, D. R., Campos, T., Coe, H., Crounse, J. D., de Gouw, J. A., DeCarlo, P. F., Dunlea, E. J., Flocke, F. M., Fried, A., Goldan, P., Goldstein, A. H., Griffin, R. J., Heald, C. L., Herndon, S. C., Holloway, J. S., Holzinger, R., Jimenez, J. L., Junkermann, W., Kuster, W. C., Lewis, A. C., Meinardi, S., Millet, D. B., Onasch, T., Polidori, A., Quinn, P. K., Riemer, D. D., Roberts, J. M., Salcedo, D., Sive, B., Swanson, A. L., Talbot, R., Warneke, C., Weber, R. J., Weibring, P., Wennberg, P. O., Wittig, A. E., Worsnop, D. R., Zhang, R., Zheng, J., Zheng, W.   +46 more
core   +7 more sources

The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy

Molecules, 2019
Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of ...
Bo Wang, Liping Wang, Ying Peng, Yiying Pang, Hesheng Xiao, Xiaoji Wang, Shuangping Huang   +6 more
doaj   +1 more source

Total Synthesis of (.+‐.)‐Hasubanonine. [PDF]

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Liwen He, Spencer B. Jones, Steven L. Castle   +2 more
openaire   +4 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation

, 2014
A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3–sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step.
Despiau, Carole F., Dominey, Andrew P., Harrowven, David C., Linclau, Bruno   +3 more
core   +2 more sources