Results 61 to 70 of about 16,454,265 (355)
Toward the total synthesis of spirastrellolide A. Part 3: Intelligence gathering and preparation of a ring-expanded analogue [PDF]
, 2007 Different methods for the formation of the C.25–C.26 bond of spirastrellolide A (1) are evaluated that might qualify for the end game of the projected total synthesis, with emphasis on metathetic ways to forge the macrocyclic ...
Ceccon, J. +5 more
core +2 more sources
Recent Advances in Total Synthesis via Metathesis Reactions
Synthesis, 2018 The metathesis reactions, in their various versions, have become a powerful and extremely valuable tool for the formation of carbon–carbon bonds in organic synthesis.
Iván Cheng-Sánchez, F. Sarabia
semanticscholar +1 more source
Total Synthesis of (‐)‐Stemonine. [PDF]
ChemInform, 2003 [reaction: see text] An enantioselective total synthesis of (-)-stemonine (1) is reported via a convergent assembly of the acyclic precursor 2. Key transformations include a Staudinger-aza-Wittig reaction to form the central perhydroazepine ring system and an iodine-induced tandem cyclization to construct the pyrrolidino-butyrolactone framework.
David R, Williams +4 more
openaire +2 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
ChemistryEuropeA concise method for the construction of dioxabicyclo[3.3.1]nonene framework has been developed. This structural motif has recently been identified in hybrid‐type pyranonaphthoquinone‐class natural products.
Yoshio Ando, Sota Ajima, Ken Ohmori
doaj +1 more source
Total Syntheses of Marine Natural Products Lyngbyabellin O and Lyngbyabellin P
Marine DrugsLyngbyabellins O and P are complex natural products derived from non-ribosomal peptide synthetase/polyketide synthase (NRPS/PKS) biosynthetic pathways and have been isolated from marine cyanobacterial sources.
Jing Chen, Shiyu Li, Chao Xu, Tao Ye
doaj +1 more source
Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative
Molecules, 2017 Hispidulin is a naturally occurring flavone known to have various Central nervous system (CNS) activities. Proposed synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall yields.
Liang-Chieh Chen +4 more
doaj +1 more source
Recent Advances on Biological Activities and Structural Modifications of Dehydroabietic Acid
Toxins, 2022 Dehydroabietic acid is a tricyclic diterpenoid resin acid isolated from rosin. Dehydroabietic acid and its derivatives showed lots of medical and agricultural bioactivities, such as anticancer, antibacterial, antiviral, antiulcer, insecticidal, and ...
Meng Hao +6 more
doaj +1 more source
Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids [PDF]
, 2015 A unified strategy for enantioselective total synthesis of all stereoisomers of the [2+2] family of quadrigemine alkaloids is reported. In this approach, two enantioselective intramolecular Heck reactions are carried out at the same time on precursors ...
Canham, SM +6 more
core +4 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source