Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. [PDF]
PLoS ONE, 2012 Staphylococcus aureus initiates infections and produces virulence factors, including superantigens (SAgs), at mucosal surfaces. The SAg, Toxic Shock Syndrome Toxin-1 (TSST-1) induces cytokine secretion from epithelial cells, antigen presenting cells ...
Matthew M Schaefers +8 more
doaj +2 more sources
Toxic Shock Syndrome Toxin-1-Mediated Toxicity Inhibited by Neutralizing Antibodies Late in the Course of Continual in Vivo and in Vitro Exposure [PDF]
Toxins, 2014 Toxic shock syndrome (TSS) results from the host’s overwhelming inflammatory response and cytokine storm mainly due to superantigens (SAgs). There is no effective specific therapy.
Norbert Stich +5 more
doaj +2 more sources
Menstrual Cup-Associated Toxic Shock Syndrome [PDF]
European Journal of Case Reports in Internal Medicine, 2020 Toxic shock syndrome (TSS) is a rare inflammatory response syndrome associated with an infection by toxigenic strains of Staphylococcus aureus or group A ?-haemolytic Streptococcus.
Christian Neumann +2 more
doaj +2 more sources
Separation of function between the domains of toxic shock syndrome toxin-1
The Journal of Immunology, 1998 Toxic shock syndrome toxin-1 (TSST1) is a superantigenic exotoxin produced by certain strains of Staphylococcus aureus Structurally, TSST1 is composed of two domains: residues determined by crystallography to directly interact with MHC II molecules ...
Wahlsten, J L, Ramakrishnan, S
core +3 more sources
Detection of toxic shock toxin (tst) gene in Staphylococcus aureus isolated from bovine milk samples [PDF]
Bulgarian Journal of Veterinary Medicine, 2017 Staphylococcus aureus is a major causative pathogen of clinical and subclinical mastitis in dairy cattle all over the world. This agent produces a variety of extracellular toxins and virulence factors in-cluding toxic shock syndrome toxin-1 (TSST-1 ...
S. Baniardalan +4 more
doaj +1 more source
mSphere, 2021 Staphylococcal enterotoxin C has four subtypes that cause human diseases, designated SEC-1 to -4. This study shows that SEC-2 and SEC-3 are the most toxic subtypes in a rabbit model and are associated with human vaginal infections or colonization in ...
Olivia N. Chuang-Smith +1 more
doaj +1 more source
Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. [PDF]
PLoS ONE, 2013 The vaginal mucosa can be colonized by many bacteria including commensal organisms and potential pathogens, such as Staphylococcus aureus. Some strains of S.
Amanda J Brosnahan +4 more
doaj +1 more source
Toxicity of staphylococcal toxic shock syndrome toxin 1 in rabbits [PDF]
Infection and Immunity, 1984 Strains of Staphylococcus aureus associated with toxic shock syndrome produce toxic shock syndrome toxin 1 (TSST 1), which is lethal to conventional rabbits and acts synergistically with gram-negative lipopolysaccharide. The lethal effect of TSST 1 was examined in specific-pathogen-free rabbits on the basis that these rabbits, being less colonized by ...
J C, de Azavedo, J P, Arbuthnott
openaire +2 more sources
BMC Biotechnology, 2022 Background Staphylococcal superantigens are virulence factors that help the pathogen escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 is one of the most studied superantigens whose role in toxic shock syndrome and ...
Mahdieh Soezi +12 more
doaj +1 more source
Prevalence of antibody to toxic shock syndrome toxin-1 in burn patients. [PDF]
Ann Lab Med, 2015 Burn wounds lack normal barriers that protect against pathogenic bacteria, and burn patients are easily colonized and infected by Staphylococcus aureus. Toxic shock syndrome (TSS) is a rare but fatal disease caused by S. aureus. A lack of detectable antibodies to TSS toxin-1 (TSST-1) in serum indicates susceptibility to TSS.A total of 207 patients (169
Park JY, Kim JS, Woo H.
europepmc +3 more sources