Results 31 to 40 of about 35,227 (304)

Intracellular expression of toxic shock syndrome toxin 1 in Saccharomyces cerevisiae [PDF]

Infection and Immunity, 1994
In order to search for an occult cytotoxic enzymatic activity of the toxic shock syndrome toxin 1 (TSST-1), we placed the gene encoding TSST-1 (tstH) under the control of an inducible promoter in the eukaryotic yeast Saccharomyces cerevisiae. Under similar circumstances, the known bacterial enzymatic cytotoxins Shiga-like toxin and diphtheria toxin are
R L, Deresiewicz, J A, Flaxenburg, M, Chan, R W, Finberg, D L, Kasper   +4 more
openaire   +2 more sources

Competitive, enzyme-linked immunosorbent assay for toxic shock syndrome toxin 1 [PDF]

Journal of Clinical Microbiology, 1985
We developed a competitive, enzyme-linked immunosorbent assay for the quantitation of toxic shock syndrome toxin 1 (TSST-1). Polyvalent immunoglobulin G from immunized rabbits was used as the capture antibody, and alkaline phosphatase conjugated to purified toxin served as the indicator enzyme.
J, Parsonnet, J T, Mills, Z A, Gillis, G B, Pier   +3 more
openaire   +2 more sources

Swine methicillin-resistant Staphylococcus aureus carrying toxic-shock syndrome toxin gene in Hong Kong, China

Emerging Microbes and Infections, 2020
We report a SCCmec II, ST39 methicillin-resistant Staphylococcus aureus isolate from pigs that harboured toxic-shock syndrome toxin gene (tsst-1). The gene was located in a rare pathogenicity island SaPI68111, which also carried enterotoxin genes that ...
Dulmini Nanayakkara Sapugahawatte, Carmen Li, Yun Kit Yeoh, Priyanga Dharmaratne, Chendi Zhu, Margaret Ip   +5 more
doaj   +1 more source

Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1

Toxins, 2017
Some Staphylococcus aureus isolates produced toxic shock syndrome toxin-1 (TSST-1) which is a pyrogenic toxin superantigen (PTSAg). The toxin activates a large fraction of peripheral blood T lymphocytes causing the cells to proliferate and release ...
Thunchanok Rukkawattanakul, Nitat Sookrung, Watee Seesuay, Nattawat Onlamoon, Pornphan Diraphat, Wanpen Chaicumpa, Nitaya Indrawattana   +6 more
doaj   +1 more source

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]

, 2009
The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA   +2 more
core   +1 more source

TSST-1 protein exerts indirect effect on platelet activation and apoptosis

Platelets, 2022
Thrombocytopenia or platelet dysfunction is a risk factor for severe infection. Staphylococcus aureus (S. aureus) releases a variety of virulence factors especially toxic shock syndrome toxin 1 (TSST-1), which may cause toxic shock syndrome. S.
Min Guo, Tiantian Yi, Qian Wang, Daqing Wang, Ping Feng, Dai Kesheng, He Chunyan   +6 more
doaj   +1 more source

Environmental factors affecting toxic shock syndrome toxin-1 (TSST-1) synthesis [PDF]

Journal of Medical Microbiology, 1987
The production of toxic shock syndrome toxin-1 (TSST-1) was studied in batch and continuous culture of Staphylococcus aureus strain 1169 in a carbohydrate-free chemically defined medium (CDM). In continuous culture oxygen- and arginine-limitation were required for steady-state TSST-1 synthesis. Aeration suppressed toxin synthesis.
S K, Sarafian, S A, Morse
openaire   +2 more sources

Localization of biologically important regions on toxic shock syndrome toxin 1 [PDF]

Infection and Immunity, 1996
Toxic shock syndrome toxin 1 (TSST-1) contains a long central alpha helix that forms the base of two grooves on opposite sides of the molecule. Previous studies indicated that residues 132, 135, and 140 along the back of the central alpha helix are important in the biological activities.
D L, Murray, C A, Earhart, D T, Mitchell, D H, Ohlendorf, R P, Novick, P M, Schlievert   +5 more
openaire   +2 more sources

Expression of toxic shock syndrome toxin-1 gene of Staphylococcus aureus in milk: Proof of concept

Mljekarstvo, 2018
The aim of this study was to assess the expression of a toxic shock syndrome toxin-1 (TSST-1) gene of Staphylococcus aureus in different types of milk, depending on inadequate temperature and storage conditions.
Milijana Babić, Marija Pajić, Aleksandra Nikolić, Vlado Teodorović, Milorad Mirilović, Lazar Milojević, Branko Velebit   +6 more
doaj   +1 more source

Enterotoxigenic Potential of Coagulase-Negative Staphylococci from Ready-to-Eat Food

Pathogens, 2020
Although coagulase-positive staphylococci are considered to be the main factor responsible for food poisoning, an increasing role for the coagulase-negative staphylococci in the production of enterotoxins has been observed in recent years. This study was
Wioleta Chajęcka-Wierzchowska, Joanna Gajewska, Patryk Wiśniewski, Anna Zadernowska   +3 more
doaj   +1 more source